Making a good thing better...
The RESTORE Infusion

The fact is...

some of the most significant research occurs at the interfaces between traditional research areas. This is even more likely to be true in the future because the solution to complex biological and health care problems require experts and expertise in many different disciplines—and increasingly expertise in more than one field.”


Let's Look At This A New Way.

RESTORE Infusion Development

When research scientists try to discover a new drug or molecule to treat an illness, like pain or depression, they approach it from what they believe is a very practical and standardized way. They have identified a problem in need of a solution, in this case chronic pain and depression, so they then try to find a new molecule, or a modification of an old one, that will correct it. This can take years of research with trial and error investigation to attempt to find the “magic bullet” cure.

That’s the standard, traditional approach. But what happened with Ketamine was very different. Ketamine is a drug that has already been around for 50 years and it was “accidentally discovered” that it could treat pain and depression far better than anything we currently have available. How could that be?...How does it work?

 

 

 

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Now the research is focused on trying to break it down “receptor by receptor” and “protein by protein” to find out how it does this. While this will be valuable information to have, it will take many more years of research and likely not add a great deal more value than we realize now….it works!

We have taken a different approach. We already know ketamine works, but if used by itself, it has several short comings…. so rather than "breaking it down" we have chosen to pursue ways to “build it up” correcting those short comings and making it even better!

To accomplish that, we adopted a strategy for integrating discoveries in medicine, physics, and cognitive science to bridge the gap between the “explanation”…. The how and why something works and the “action”…we know that it works, now how do we apply it and make it better?


 

Even though Ketamine has been around for a long time very few people know much about it and even fewer have had the opportunity to use it. To a large degree it’s almost an “orphan” drug in the field of Anesthesiology but it has recently been "rediscovered" and found that it has pretty remarkable effects.

But even before it was found to be helpful in depression, its ability to treat chronic, intractable, neuropathic pain was known in the pain community but it was never widely exploited…and there are a few very important reasons for that…. Well, I think that’s about to change and I would like to tell you why.

 

Tag Line RRR

New Study Investigates Ketamine as A Potential Treatment for COVID-19

Ketamine may have a new role in combating the “cytokine storm” associated with serious Covid-19 infections.

Ketamine, a safe and effective anesthetic medication developed in the 1960’s, well known for its ability to rapidly improve symptoms of depression, anxiety and PTSD is finding its way to the front line of the global fight to develop an effective treatment for COVID-19.

In addition to its ability to treat mood disorders and chronic pain, ketamine has long been known to reduce serious forms inflammation and was used in the 1990’s to successfully treat critically ill patients suffering from the near uniformly fatal rabies virus. Now researchers from the Beaumont Healthcare System are using it in combination with Naltrexone to potentially help those with COVID-19 infections.

Below is a reprint of the press release they recently issued, it may be viewed directly at: https://www.beaumont.org/health-wellness/press-releases/sink-covid-19-study-can-common-drugs-offer-2-step-approach-to-combat-deadly-virus

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Monday, May 04, 2020

Beaumont researchers hopeful medications can reduce severity of COVID-19 and save lives

Researchers at Beaumont Hospital, Royal Oak have begun enrolling patients in a new clinical study aimed at treating COVID-19 patients with two common drugs – naltrexone and ketamine. It’s called SINK COVID-19, or the Study of Immunomodulation using Naltrexone and Ketamine for COVID-19.

The single center, randomized study is only for patients, 18 years and older, hospitalized at Beaumont, Royal Oak for the treatment of COVID-19 meeting specific criteria.

Beaumont researchers are hopeful the two drugs can lessen the severity of COVID-19 symptoms by reducing the early and later side effects of the virus.

“There is an urgent need to develop new treatments for COVID-19 using easily available and affordable medications,” said Dr. Matthew Sims, director, Infectious Disease Research, Beaumont Health and study principal investigator. “Ideal new treatments for COVID-19 would help halt the progression of the disease in patients with mild cases prior to the need for ventilators, and provide a rescue treatment for patients with severe cases of the virus.”

The United States Food and Drug Administration's Investigational New Drug program granted Beaumont researchers permission to start this clinical study.

Dr. Annas Aljassem, study co-investigator, said, “We need a two-pronged strategy to combat COVID-19. Low doses of naltrexone, a drug approved for treating alcoholism and opiate addiction, as well as ketamine, a drug approved as an anesthetic, may be able to interrupt the inflammation that causes the worst COVID-19 symptoms.”

Low-dose naltrexone has been used for the treatment of pain and inflammation in multiple sclerosis, Crohn’s disease, fibromyalgia and other pain conditions. Ketamine, an anesthetic drug, shows anti-inflammatory effects at multiple early steps in the inflammatory process.

“The addition of these two medications, as immunomodulators, to the treatment regimen of patients with COVID-19 has potential to decrease the severity of this disease by reducing the autoimmune, hyperinflammatory stages of the virus which is destructive to normal tissue and, when unchecked, rapidly leads to death,” Dr. Sims said.

The study was conceived and designed by Dr. Aljassem and Dr. Sims. Investigative team members also include Dr. Carl Lauter and Dr. Levi Hall.

The Applebaum Family Foundation, Beaumont Foundation, along with Suzanne and Deborah Tyner are supporting this study.

For more information on the study, go to clinicaltrials.gov, identifier: NCT04365985.
Ketamine and naltrexone, two widely-used drugs formulated in the 1960s, are finding their way to the front line of the global fight to develop a cure for COVID-19

Beaumont Health has announced the launch of a new clinical study aimed at treating COVID-19 patients using naltrexone and ketamine. It also received approval from the U.S. Food and Drug Administration to launch the new clinical trial. This company is Michigan’s largest healthcare system based on revenue and inpatient admissions.

The study is called “SINK COVID-19” and will be conducted at the Beaumont Hospital in Royal Oak, Oakland County. SINK stands for the "Study of Immunomodulation using Naltrexone and Ketamine" for COVID-19. It has been designed as a randomized study for patients 18 years and older.

Beaumont researchers are hopeful both drugs can lessen the severity of COVID-19 symptoms by reducing the early and later side effects of the COVID-19 coronavirus. They intend to use the drugs as immunomodulators added to the treatment regimen of patients with COVID-19.

Reprint from Newswise: https://www.newswise.com/coronavirus/sink-covid-19-study-can-common-drugs-offer-2-step-approach-to-combat-deadly-virus/?article_id=731140

Newswise — Researchers at Beaumont Hospital in Royal Oak, Michigan have begun enrolling patients in a new clinical study aimed at treating COVID-19 patients with two common drugs – naltrexone and ketamine. It’s called SINK COVID-19, or the Study of Immunomodulation using Naltrexone and Ketamine for COVID-19.

The single center, randomized study is only for patients, 18 years and older, hospitalized at Beaumont, Royal Oak for the treatment of COVID-19 meeting specific criteria.

Beaumont researchers are hopeful the two drugs can lessen the severity of COVID-19 symptoms by reducing the early and later side effects of the virus.

“There is an urgent need to develop new treatments for COVID-19 using easily available and affordable medications,” said Dr. Matthew Sims, director, Infectious Disease Research, Beaumont Health and study principal investigator. “Ideal new treatments for COVID-19 would help halt the progression of the disease in patients with mild cases prior to the need for ventilators, and provide a rescue treatment for patients with severe cases of the virus.”

The United States Food and Drug Administration's Investigational New Drug program granted Beaumont researchers permission to start this clinical study.

Dr. Annas Aljassem, study co-investigator, said, “We need a two-pronged strategy to combat COVID-19. Low doses of naltrexone, a drug approved for treating alcoholism and opiate addiction, as well as ketamine, a drug approved as an anesthetic, may be able to interrupt the inflammation that causes the worst COVID-19 symptoms.”

Low-dose naltrexone has been used for the treatment of pain and inflammation in multiple sclerosis, Crohn’s disease, fibromyalgia and other pain conditions. Ketamine, an anesthetic drug, shows anti-inflammatory effects at multiple early steps in the inflammatory process.

“The addition of these two medications, as immunomodulators, to the treatment regimen of patients with COVID-19 has potential to decrease the severity of this disease by reducing the autoimmune, hyperinflammatory stages of the virus which is destructive to normal tissue and, when unchecked, rapidly leads to death,” Dr. Sims said.

The study was conceived and designed by Dr. Aljassem and Dr. Sims. Investigative team members also include Dr. Carl Lauter and Dr. Levi Hall.

The Applebaum Family Foundation, Beaumont Foundation, along with Suzanne and Deborah Tyner are supporting this study.

For more information on the study, go to clinicaltrials.gov, identifier: NCT04365985.


 

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