To us, it's all about finding your own path....
RESTORE Infusion...The "measured-target approach"
in Ketamine-Based Therapy
Anything worthwhile takes time...
RESTORE results from over 35 years of my clinical research and experience using ketamine, personally administering ketamine-based therapy, to treat a wide variety of complex and challenging medical issues to patients who have come to us from around the world seeking help.
I formulated the RESTORE Infusion protocol to improve and optimize the standard ketamine infusion that was developed at my former institution - the Yale Department of Anesthesiology - in 1994. The goal was to make ketamine-based infusion therapy as rapid, effective, and long-lasting as possible.
Over the years of my work with ketamine, I have given thousands of ketamine infusions and have been personally present for the whole of every one. The knowledge, experience, and insights gained by personally guiding hundreds of patients through thousands of ketamine infusions have been invaluable in learning how to unlock the therapeutic potential of ketamine.
After devoting over three decades to the clinical use, research, and development of this innovative therapy, employing metabolic optimization, precision medicine and targeted infusion therapy, I have developed a ketamine infusion protocol built around a measured target concentration in the blood rather than a dose multiplied out from body weight in the RESTORE Infusion.
Today, the RESTORE infusion® is dosed to a measured target rather than to body weight
Learn more about the inventor of the RESTORE Infusion
About Us
We are committed to what we do, and we focus on just one thing - ketamine-based therapy. We will use all of our knowledge, experience and expertise to help each person we meet. Our commitment is to the process, not to an outcome.
We are working every day to help individuals who are suffering from complicated and treatment-resistant disorders that have not responded to earlier treatment. It can be difficult, and it takes time, effort, and experience working with one person at a time to do this well.
We also continue to explore new applications for the therapeutic potential of ketamine in other illnesses, such as neurodegenerative, autoimmune and inflammatory disorders. That work is exploratory research, and it is not a treatment we offer for those conditions.
More than anything, we want this current therapy to be more readily accessible and affordable to those who could benefit from it, so we educate other doctors and medical practitioners on how to use and administer ketamine treatment delivered to a defined standard of safety and measurement to their own patients.
The Ketamine Research Institute was founded to continually improve and perfect ketamine treatment for an expanding range of chronic illnesses. We built the RESTORE Infusion Program around the original standard ketamine infusion, changing how the dose is worked out and how the course is delivered. After devoting almost two decades to the clinical use, research, and development of this innovative therapy and by employing precision medicine and targeted therapy, we have developed a ketamine infusion protocol built around a measured target concentration in the blood rather than a dose multiplied out from body weight in the RESTORE Infusions®.
In addition to the metabolic and genetic optimization of each patient we see, the RESTORE infusion process combines ketamine with magnesium. Our highly trained medical specialists then administer our infusion using a proprietary 3-stage variable rate infusion protocol to provide optimal blood levels for a more extended time. That is why the dose is calculated to reach and hold a target concentration rather than multiplied out from body weight.
We are a very specialized center devoted exclusively to ketamine treatment, clinical research, education, and training physicians worldwide in the use of ketamine. We have developed an intensive training program for clinicians using Ketamine Infusion Therapy for Mood Disorders. We also keep in regular contact with clinicians and centers in Australia and Europe, sharing knowledge and experience with them informally. The Ketamine Research Institute has written its own standards for ketamine infusion practice. Our goal is to give you an honest assessment of whether ketamine infusion therapy is likely to help you.
Our Training Program...
Setting the Standards...
A Little History About Ketamine...
The original ketamine infusion for the treatment of depression was first discovered in 2000 at the Yale University School of Medicine by Robert Berman, MD, and others. The Department of Anesthesiology assisted in formulating and administering the very first infusion protocol of "0.5 mg/kg given over 40 minutes" in 1994. This original protocol has since become the "standard" ketamine infusion and is currently used by many others worldwide as a rapid treatment for depression and other conditions.
I was also very involved in the early days of ketamine treatment, using it to help patients find relief from chronic pain. Even before that, as far back as the mid-1990s, I utilized this amazing medication to treat pain and later used it extensively at the Mount Sinai Medical Center in New York City before our work at Yale. Those of us with previous ketamine infusion experience knew that it was remarkably effective for depression and pain and for treating many related disorders. The problem was that no one knew the most effective dose or formulation of ketamine for any individual patient. Secondly, the very rapid beneficial effects only lasted a few days. Well, that was certainly a good start, but I knew it could be better, and that realization and understanding led to the development of RESTORE.
The Ketamine Research Institute was founded to expand and perfect ketamine infusion therapy. I have spent years improving on the original "standard" ketamine infusion protocol, treating hundreds of patients with some of the most severe and complex pain, depression and anxiety disorders imaginable. Now we have been able to solve many of the issues that faced us before with the RESTORE Infusion Program - Essential and Advanced
the "measured-target approach" in ketamine therapy
Learn how RESTORE differs from a standard ketamine infusion
Through our expanding research efforts to explore its broader application, we are studying how ketamine based infusion therapy behaves in fibromyalgia, neuropathic pain, PTSD and migraine. That work is exploratory and no result can be promised.
We bring together a multidisciplinary international collaboration in the field of ketamine-based therapy, bringing together scientists, clinicians, healthcare providers, and policy makers to stimulate and support the study of ketamine and to translate that knowledge into improved relief worldwide.
The Ketamine Research Institute provides...RESTORE - the "measured-target approach"
We are proud to be a center in the United States dedicated solely to the advancement of RESTORE Infusion Therapy. We provide education to other physicians in its use and we apply the published research on ketamine dosing and monitoring in our own practice.
Learn more about the RESTORE Infusion Center here >
