To us, it's all about finding your own path....

American physicist Joseph Henry once noted:

"The seeds of great discoveries are constantly floating around us, but they only take root in minds well prepared to receive them."

RESTORE Infusion...The "Gold Standard"
in Ketamine-Based Therapy

It takes time...

As a former Assistant Professor in the Department of Anesthesiology of Yale School of Medicine, where the ketamine infusion for depression was developed in 1994, I have had years of experience with ketamine and developed RESTORE infusion to improve upon the regular, standard ketamine infusion. I have spent the last 25 years studying and using ketamine to successfully treat many of the most challenging, complex, and severe "treatment-resistant" conditions. After devoting two decades to the clinical use, research, and development of this innovative therapy, employing precision medicine and targeted therapy, we have developed the most advanced ketamine-based treatment available in the RESTORE Infusions.

Learn more about the inventor of the RESTORE Infusion


About Us

We are committed to what we do. We will use all of our knowledge, experience, training, and expertise to provide you with the best possible treatment available for relief.  Helping people who suffer from migraines, fibromyalgia, and depression is our mission.  It can be challenging and requires time, effort, and expertise to achieve the best possible result.  There are many factors to consider when approaching complex medical issues, and we look at each person as an individual.

The Ketamine Research Institute was founded to continually improve and perfect ketamine treatment for an expanding range of chronic illnesses. We have improved the original standard ketamine infusion with the RESTORE Ultra-Rapid Infusions® - the most effective, efficient, and longest-lasting treatments available. After devoting almost two decades to the clinical use, research, and development of this innovative therapy and by employing precision medicine and targeted therapy, we have developed the most advanced ketamine-based treatment available in the RESTORE Infusions®.

In addition to metabolic and genetic optimization of each patient we see, the RESTORE infusion process is a unique combination of ketamine and magnesium, making it more effective.  Physicians then administer our infusion using a proprietary 3-stage variable rate infusion protocol to provide the optimal blood levels for a more extended time. That is why RESTORE is faster acting, more effective, and longer-lasting than a regular ketamine infusion. And the beneficial results can begin in just minutes to hours after the first infusion.

We are a very specialized center devoted exclusively to ketamine treatment, clinical research, education, and training physicians worldwide in the use of ketamine. We have developed the first and most comprehensive educational training program for physicians using Ketamine Infusion Therapy for Mood Disorders.  More than that, we have established an international multidisciplinary collaboration initiative with centers in Australia and Europe to share knowledge and expertise with physicians on the cutting-edge of ketamine therapy.  Also, to ensure that all ketamine centers provide treatment most effectively and safely, the Ketamine Research Institute has developed the first International Standards for Ketamine Infusion Centers in collaboration with our partners.  Our goal is to ensure that you have the best possible opportunity to improve with ketamine infusion therapy.

Our Training Program...

Setting the Standards...

A Little History About Ketamine...

The original ketamine infusion for the treatment of depression was first discovered in 2000 at the Yale University School of Medicine by Robert Berman, MD and others.  The Department of Anesthesiology assisted in formulating and administering the very first infusion protocol of "0.5 mg/kg given over 40 minutes" in 1994. This original protocol has since become the "standard" ketamine infusion and is currently used by many others worldwide as a rapid treatment for depression and other conditions.

I was also very involved in the early days of ketamine treatment, using it to help patients find relief from chronic pain. Even before that, as far back as the mid-1990s, I utilized this amazing medication to treat pain and later used it extensively at the Mount Sinai Medical Center in New York City before our work at Yale. Those of us with previous ketamine infusion experience knew that it was remarkably effective for depression and pain and for treating many related disorders. The problem was that no one knew the most effective dose or formulation of ketamine for any individual patient. Secondly, the very rapid beneficial effects only lasted a few days. Well, that was certainly a good start, but I knew it could be better, and that realization and understanding led to the development of RESTORE.

Standard versus Restore

The Ketamine Research Institute was founded to expand and perfect ketamine infusion therapy. I have spent years improving on the original "standard" ketamine infusion protocol, treating hundreds of patients with some of the most severe and complex pain, depression and anxiety disorders imaginable. Now we have been able to solve many of the issues that faced us before with  the RESTORE Ultra-Rapid Infusions - Essential and Advanced

the "Gold-Standard" in ketamine therapy

Learn why RESTORE is better than ketamine



new ways of thinking

We Put The Pieces Together

Today, through our use of Precision Medicine and  exploration of allied fields in medicine, neuroscience, pharmacogenomics and cognitive science, we have discovered and pioneered synergistic ways to enhance its effectiveness and extend the duration of the RESTORE Ultra-Rapid Infusion beyond anything currently reported in the medical literature.

Our research and development efforts have unlocked the keys to the most effective, rapid and long lasting treatment of pain and depression available today.  This unique and proprietary ketamine based infusion protocol known as RESTORE represents the next generation of clinically proven rapid, effective, long-lasting and safe ketamine based infusion treatment.

Learn why not all ketamine infusions are the same


Through our expanding research efforts to explore its broader application, RESTORE is also be the first medication/protocol of its kind to relieve symptoms of Fibromyalgia, Neuropathy, PTSD, migraine headache, as well as, many other serious conditions such as pelvic pain-vulvodynia-pudendal neuralgia.


Our new location

We Work As A Team

This is a team effort and requires expertise from many related fields. To ensure our patients comprehensive care, the Ketamine Research Institute and our trained and certified practitioners collaborate on an ongoing basis sharing knowledge and expertise in this rapidly expanding field. We network to share the latest developments in the field, answer questions and build a shared database to conduct clinical research into ketamine-based therapy.

Chronic pain and mood disorders represent an immense clinical problem. With tens of millions of people in the United States alone suffering from the burden of these debilitating illnesses, there is a moral obligation to reduce this burden by improving the understanding and treatment mechanisms, developing new therapies, optimizing and testing existing therapies, and improving access to evidence-based care.


We bring together a multidisciplinary international collaboration in the field of ketamine-based therapy, bringing together scientists, clinicians, healthcare providers, and policy makers to stimulate and support the study of ketamine and to translate that knowledge into improved relief worldwide.


There is only one center in the United States...RESTORE - the "Gold Standard"

We are proud to be the only center in the United States dedicated solely to the advancement of RESTORE Infusion Therapy. We provide education to other physicians in its use and bring the latest breakthrough discoveries about ketamine out of the research lab and into our infusion centers to help the people who need it most today.

Learn more about the RESTORE Infusion Center here >

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What patients are saying about the RESTORE Infusion

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The RESTORE Infusion
Revolutionizing Ketamine Therapy