Just a few questions
What is Ketamine Treatment? What You Need To Know
Our remarkable 3-day RESTORE infusion program can lead to rapid change and dramatic improvement by quickly "restoring" your neurochemical balance and rapidly "rebooting" neural connections, allowing you to enjoy life again. But more than that, it also rapidly reduces inflammation associated with chronic stress, depression, and pain, while helping to restore immune and hormonal functions to normal. And the unique transformational experiences that are often encountered during the sessions provide you with the opportunity to experience a new, vital, and expanded perspective of life.
The advantage of RESTORE is that it works much faster and lasts longer than any ketamine infusion. Our initial 3 RESTORE Essential infusions are the therapeutic equivalent of at least 9 ketamine infusions. The entire program takes just 3 days — compared to 2 weeks with ketamine — and it lasts 3-6x longer than a ketamine infusion, so you feel better much longer and makes RESTORE significantly more cost-effective than ketamine.
We understand that living with chronic stress, depression, anxiety, or chronic pain can be difficult, but considering RESTORE Infusion Therapy® is a step in the right direction. And you're not alone, we have been there too, and we understand what it's like.
The RESTORE program is intensive, highly individualized, and strictly confidential. We don't treat patients. We help people, one person at a time.
Your first step...Find a Trained and Certified Ketamine Physician
The first step in your journey should be finding a trained and qualified physician to administer ketamine infusions safely and effectively according to the American Psychiatric Association and the American Society of Anesthesiologists guidelines.
"Ketamine Clinics" are becoming more common in some communities and unfortunately can vary widely in terms of quality, experience, and expertise. Some physicians providing ketamine infusion therapy may be well-meaning but have little knowledge or formal training in ketamine infusion therapy. They frequently heard about the remarkable benefits of ketamine for depression and anxiety, read one or two papers published on the subject, and then think that they are qualified to begin performing infusions. Because of this, results can vary widely, and many patients do not achieve the full benefits of ketamine therapy.
Ketamine therapy is an exact and meticulous therapy that requires experience and expertise. Unfortunately, some physicians may see ketamine infusion therapy as a simple office procedure that requires little or no direct involvement on their part and can produce some additional revenue for their practice. They often see other patients while a nurse starts your infusion in an isolated exam room and occasionally "check in on you."
In our view, and the opinion of the American Psychiatric Association, this is not a safe practice. Let's not forget that ketamine is a potent medication, and it is an anesthetic drug. You should be very cautious if the doctor is only with you for 5 minutes before the infusion or a fully trained member of the healthcare team is not with you at all times during your infusion.
5 Important Things to Ask and Warning Signs to Look Out For...
1. Be very skeptical of any "ketamine clinic" that uses a "call-in" answering service to give you information. Often you will be speaking to someone in a remote location with no personal knowledge of ketamine therapy which can only answer simple questions from a script. They may only be concerned with offering you an appointment in the clinic as soon as possible. It would help if you spoke to someone with direct knowledge and experience in ketamine infusion therapy who can answer all of your questions from the start.
2. Ask where they were trained in the use of ketamine. Your physician should be thoroughly trained and experienced in administering ketamine for mood disorders and related conditions. Ask if they are certified in ketamine therapy. The Ketamine Research Institute trains physicians from around the US and Internationally to administer ketamine safely, under strict protocols and guidelines set forth by the American Psychiatric Association and the American Society of Anesthesiologist recommendations.
3. Be very careful if they do not assure you that a fully qualified member of the health care team will be you at all times during the infusion session. It is not advisable to have someone from the office "check in on you" every once in a while. You are being given a very potent medication and should be observed and monitored continually during your treatment.
4. Be suspicious of any provider that prescribes supplemental ketamine in a nasal spray or oral formulation. There are many unintended consequences to using such agents, including the possibility of having adverse side effects, becoming dependent, or developing tolerance to the medication quickly and thereby losing its effect rapidly.
5. Be concerned if they do not require your medical records. All legitimate physicians providing ketamine to a patient will request medical records and labs from your doctor. If they do not ask for these documents or say that they are unnecessary, that may be a warning sign that they may not be reputable and are operating a "mill" type of operation.
*Now that you know the advantages of RESTORE, if you still feel that regular ketamine
infusion therapy is an option for you, then please read our guide on
How to Choose The Best Ketamine Infusion Center - 2021.
Before we look at RESTORE, let's first look at regular ketamine infusion therapy.
Did you know that only 50% of people may respond to ketamine infusion therapy?
Although ketamine infusion therapy can be remarkably rapid and effective for patients with treatment-resistant depression under research conditions, that is not always the case in actual practice. Research studies report that up to 70% of patients in a clinical research setting improve following ketamine infusion treatment. Unfortunately, while many ketamine clinics will quote that number, far fewer people undergoing ketamine infusion therapy in a ketamine clinic are likely to do as well.
Is a 50/50 chance of improvement really the best that can be expected?
In reality, your chances of experiencing improvement when a ketamine infusion takes place in a local ketamine clinic could be significantly different - and much lower (1). Some believe a more realistic expectation is that only about 50-60% of people respond to ketamine infusions when given in a ketamine clinic setting. In fact, according to one recent report, just 44% of patients with treatment-resistant depression responded favorably after six infusion sessions in a community hospital setting (2).
There are many reasons for the lower response rate you may experience. Often, this includes a number of factors that can contribute to you success or lack of it. For example, many clinicians providing ketamine therapy lack adequate training or experience administering ketamine, or they may not adhere to appropriate patient selection and treatment standards. Equally as important, they may not appropriately adjust ketamine dosing based on critical factors such as your medications, metabolism, or genetic profile.
Be aware of how time consuming and expensive ketamine can be.
Regular ketamine infusions, when performed by qualified and experienced clinicians who have strict standards and following treatment protocols, can unquestionably be effective for many people — they have some significant limitations and drawbacks that you need to be aware of.
The first limitation for some people is that regular ketamine infusion, while helpful in mood disorders such as depression or anxiety, is not very helpful or effective for treating chronic pain. Next, it will require at least six infusions over two weeks to complete the initial treatment series, and you may not know if it's even working until around the third session. As a result, determining whether it is effective for you may take some time.
Ketamine infusion can be very time consuming.
Many people may find it difficult or impossible to take every other day off from work, school, or their household responsibilities for two weeks to have the therapy. More than that, it is important to remember that you will need someone to drive to and from each of those infusion sessions.
Then there is the overall expense involved.
When you ask, most local ketamine clinics will tell you the single infusion cost, but that can be misleading and is not reflective of the overall costs involved . It is essential to remember that you must multiply the single infusion cost by six or more sessions just to finish the initial treatment series.
More than that, if it is helpful improving out mood and well being it may only last for about 4-6 weeks before you need another infusion to help feeling well. So, to maintain the benefit, you will need to continue having infusions every 4-6 weeks after that for an unknown amount of time.
Regular ketamine infusions can become very costly over just the first year – depending upon your location and the clinic, it can amount to over $8,500.00 in many cases.
How is the RESTORE different from other treatments?
First, let's look at what you can expect from a "typical ketamine infusion" used in many centers:
Each person is different and will respond differently to any "standard" dose of medication. But, a typical responder to ketamine-based Therapy can expect to see at least a 50% improvement in their mood for approximately four weeks following an infusion. The progress maybe a little longer in some and shorter in others.
Responders to standard ketamine-based Therapy generally fall into what is known as a normal distribution curve in which 15% have extended benefits longer than four weeks, while 70% will require maintenance every four weeks (21-28 days) to maintain the improvement. The remaining 15% need them even more frequently.
Although the benefits of ketamine-based Therapy far exceed those of conventional antidepressants, some have compared ketamine to a "band-aid" type of approach to treatment. You may see improvement for a short time but never entirely obtain long-term benefit—substituting taking antidepressants every day in exchange for ketamine infusions every month.
We knew ketamine could be made better and more effective!
As a former Assistant Professor in the Department of Anesthesiology of Yale School of Medicine, where the ketamine infusion for depression was first developed, I have had years of experience with ketamine and developed RESTORE infusion to improve upon the essential ketamine infusion. Using RESTORE, we have successfully treated some of the most challenging cases that have not been helped with any other conventional, alternative medical therapy or even multiple regular ketamine infusions. It may also be helpful to know that our patients come to us from across the country and worldwide and are considered the "gold standard" in ketamine-based Therapy.
Most people who come to us do so because RESTORE can be completed in just 3 days compared to 2 weeks with ketamine. The improvements seen with RESTORE last much longer than ketamine infusion therapy. Rather than needing ongoing maintenance infusions, after two RESTORE maintenance sessions, most of our patients find they only need a "reboot" infusion once or twice a year to stay well. Many experienced long-term remission (1-2 years or more) following just several maintenance infusions.
The advantages of RESTORE are simple: it works much faster, lasts a great deal longer, requires far fewer maintenance infusions than a ketamine infusion, and costs 30-40% less than continued ketamine treatments.
Another benefit is that many of our patients find that they can then begin to reduce or eliminate many of the medications they took before RESTORE and avoid all of the unwanted side effects of antidepressants.
Our protocol has been developed over many years of clinical investigation and application. In addition to metabolic and genetic optimization of each patient we see, the RESTORE infusion process is a unique combination of ketamine and magnesium to make it much more effective, that it is then administered by our physicians using a unique, proprietary 3-stage infusion protocol to providing each person with the optimal RESTORE serum concentration necessary to obtain the best response. That is why just 3 RESTORE infusion work better than 9 ketamine infusions. And you can begin to notice the improvement in just minutes to hours after the very first infusion.
So, now you know a few of the differences between RESTORE and other ketamine infusions. RESTORE is faster acting, longer-lasting, and treats more conditions effectively while being less expensive than any additional ketamine infusion. Learn more about the RESTORE Infusion Center and our transformational program.
We have spent almost 20 years researching and developing ways to enhance the effects of ketamine and to make it last much longer. By utilizing Precision Medicine and Targeted Therapy combined with cutting-edge research and innovations in Anesthesiology, neuropharmacology, and neurocognition, we have significantly improved ketamine's ability to treat depression, anxiety, PTSD.
We are the only center in the United States that offers both the RESTORE Ultra-Rapid Infusion and the Yale-National Institute of Mental Health "Standard ketamine infusion" protocols. Each has its advantages and it is important to recognize the difference between them to determine which might be best for your individual needs.
The RESTORE Ultra-Rapid Infusions are different from the "standard infusion" and are the most advanced formulation of ketamine therapy available. It is faster and more effective than any other ketamine infusion and, when combined with Precision Medicine and Targeted Therapy, can last 3-6 times longer than the standard infusion.
The beneficial results can begin in just as few minutes to hours after the very first infusion!
What conditions can the RESTORE Advanced Ultra-Rapid Infusion treat?
We are just beginning to learn and appreciate the full range of conditions that ketamine can help. It has been known for years to treat all forms of chronic neuropathic pain and depression.
In chronic pain, for instance, the number of neuropathic pain conditions is vast and include such conditions as:
Depression Migraine Headaches
Generalized Anxiety Fibromyalgia
Bipolar Disorder Peripheral Neuropathy
Post Traumatic Stress Disorder Chronic Neuropathic Pain
"Burnout" Syndrome Complex Regional Pain Syndrome
Pelvic Pain Vulvodynia and pudendal neuralgia
But even more than that, we now see that it has broader applications and is successful in treating pelvic pain and vulvodynia/pudendal neuralgia. There is also research to support the beneficial effects of RESTORE in the treatment of Alzheimer's Disease, Parkinson's Disease, and other neurodegenerative disorders. It should come as no surprise because we also have recently discovered that all of these conditions share many of the same neural pathways that ketamine targets.
What is Ketamine?
Ketamine has been described as the most important breakthrough in treating depression, anxiety, and chronic pain in the last fifty years. It is an FDA-approved anesthetic drug that has been used safely and effectively in hospitals worldwide since the 1960s. In the last few years, numerous articles in medical journals have shown efficacy in using ketamine in sub-anesthetic doses to treat depression and some chronic pain syndromes. Major drug companies are now taking note of its remarkable effects and rushing into developing medications based upon its results.
Ketamine's anesthetic effects are mediated by interactions with the NMDA receptor member of the glutamate receptor family. It also interacts with other receptors, including opioid receptors, dopamine receptors, and a receptor known as the AMPA receptor thought to be an essential component of its antidepressant effects.
For the past 20 years, researchers have known that tiny doses of ketamine can rapidly relieve depression symptoms when delivered via slow intravenous infusion. Yale University School of Medicine published the first scholarly paper describing this discovery in 2000. Since then, Yale and other major institutions have conducted dozens of more studies, including the National Institutes of Health, Harvard, Johns Hopkins, Mount Sinai Medical School, Oxford University, and more. The original findings have been reconfirmed many times.
Although medical professionals are going "off-label" when using ketamine to treat patients with chronic pain and depression, as many of 40% of all prescriptions written for patients in the US are used "off-label". Examples of this include such things as the use of antidepressants for pain, anticonvulsant medication to treat Fibromyalgia and even blood pressure drugs to regrow hair. Fortunately for ketamine there are many clinical trials supporting the evidence that this drug successfully treats those who suffer from chronic pain and depression when nothing else can.
Doctors and scientists report that their deeply depressed patients who are treated with ketamine respond within just a few hours! No other drug used for depression has the ability to bring relief in anywhere near this short amount of time. And with infusions administered in sequential fashion fundamental brain healing can occur.
Is RESTORE Ultra-Rapid Infusion Therapy right for me?
Not everyone needs RESTORE. Many people do well enough with the standard ketamine infusion. To make this beneficial therapy more affordable and available to those who could benefit from it, we can also provide ketamine infusions for $400.00.
But, if you suffer from more severe or long-term depression, anxiety, PTSD, or chronic pain and have not had relief with prescription medication or other traditional treatment modalities. The RESTORE Ultra-Rapid Infusion program may be an option for you.
Also, if you have undergone a standard ketamine infusion in the past but the results were not what you had hoped for, or your improvement only lasted for a few weeks, then RESTORE can be very helpful. The procedure is easy to administer and essentially pain-free. In just 3 days and with 3 infusions, you can obtain more rapid, effective, and longer-term relief than is possible with any other ketamine infusion.
We are happy to provide you with an initial consultation to see if RESTORE is suitable for you.
Who is not a good candidate for ketamine therapy?
The RESTORE Ultra-Rapid Infusion can tremendously benefit many people with serious illnesses. Still, just as with any other medical therapy or procedure, some individuals with specific medical conditions would not be appropriate for this type of therapy. The states, which would represent a "contra-indication" to ketamine therapy, include anyone with a known:
• Hypersensitivity (Allergy) to ketamine:
• A recent heart attack – less than six months ago or a:
• A recent stroke – less than one year ago
Also, the use of certain medications may interfere with obtaining the best possible result from the infusion. For example, patients taking large doses of benzodiazepines may have a reduced response to ketamine. While this does not mean you can't receive ketamine treatment while taking benzodiazepines. It is perfectly safe; we want to ensure the best possible chances for your success. We may ask you to skip a dose 24-48 hours before starting your infusion and wait until 6 hours before resuming your benzodiazepine. Some common brand names for benzodiazepines are Xanax (Alprazolam), Ativan (Lorazepam), Valium (Diazepam), and Klonopin (Clonazepam).
There are currently three other medications, which are known to interfere or block the response to ketamine significantly, and these are lamotrigine (Lamictal), risperidone (Risperdal), and olanzapine (Zyprexa). They are "relative contraindications" to therapy and may need to be reduced or discontinued before treatment.
Before arranging treatment, we would like to speak with you and discuss your current medical issues and medications. You should not adjust your dose or frequency of use of any prescribed medication without first consulting with your prescribing physician.
How many RESTORE Ultra-Rapid Infusions will I need?
Only 3 infusions are generally required.
We have spent many years determining the optimal formulation and number of infusions to increase the durability of ketamine-based therapy. RESTORE is a very advanced formulation of the "ketamine infusion," Because of that, our patients only need 3 infusions given over successive days to obtain more rapid, effective, and prolonged beneficial effects.
RESTORE Ultra-Rapid Infusion Therapy is a significantly more advanced, innovative protocol than in 1994 at Yale. We have incorporated both Precision Medicine and Targeted Therapy with the latest research advancements in Neuropharmacology, Anesthesiology, and Cognitive Neuroscience to significantly increase the effectiveness and duration beyond anything currently available. RESTORE is the only ketamine-based infusion that can provide long-term remission of symptoms without the need for continued "maintenance" infusions.
Our infusions help those individuals who suffer from complex issues such as severe chronic pain and medically intractable "treatment-resistant" depression or PTSD. If you have had "standard" ketamine therapy in the past and found that it was ineffective or did not last very long, RESTORE can help. Or, if you have had "standard" ketamine therapy and would like to continue it, or if you would prefer to begin with the standard infusion, we can certainly provide that as well.
A RESTORE Ultra-Rapid Infusion results can be seen very quickly, in as little as one treatment, but may not appear until after the entire course of treatment is complete. Many of our patients who respond see significant improvement the day after their 2nd infusion. A small percentage of the population (approximately 15%-17% or about 1 in 6 people) have an "unusual" configuration of their NMDA ketamine receptor, a BDNF or MTHFR variant, or low acetyl-L-carnitine levels and are less responsive to ketamine therapy in any form.
At present, there is no commercially available way to determine or test for those people who have the "unusual" receptor. Still, we are hopeful that the lab test will be available in the next 1-2 years.
How long is the infusion?
Generally speaking, you will be with us at the RESTORE Infusion Center for approximately 2 to 3 hours, sometimes a little longer. The length of the infusion may depend on your diagnosis and protocol; most of the infusions will be 30 minutes in length. After the infusion, you will stay for another 30 minutes to recover.
What should I expect during my RESTORE Ultra-Rapid Infusion treatments?
That's a great question. The RESTORE Infusion experience is unique and very personal for each patient…for a more detailed explanation, please go to the RESTORE Infusion Experience page.
Generally, patients commonly feel very relaxed following an infusion. On rare occasions, some patients experience nausea after an infusion. If so, we have medication that will relieve this. If you are prone to nausea, we can administer an anti-nausea medication before the infusion to help prevent it.
Any mild side effects usually dissipate within a few hours and are completely gone by the following day. There are zero long-term or permanent side effects following medically supervised IV ketamine infusion therapy.
Will I require RESTORE therapy for the rest of my life?
No, not with RESTORE...just 3 infusions can provide long-term relief.
RESTORE Advanced is the only ketamine-based infusion that can provide long-term improvement of symptoms without the need for continued "maintenance" infusions.
After the initial series of three RESTORE Essential infusions restores the brain to a healthy balance, it is generally easier to maintain that balance than it was to attain it in the first place. Follow-up or "maintenance" infusions are recommended at the three-month mark and one more six months following that. After this, many of our patients enjoy long-term benefits and only return on an "as-needed" basis. That is one reason why RESTORE is considered the "Gold Standard" in ketamine-based therapy.
I have responsibilities and a job...can I receive
RESTORE Ultra-Rapid Infusions at a convenient time for me?
Yes, you can...we offer weekend appointments.
Most out-of-town patients find it more convenient to schedule treatments over a long weekend to avoid prolonged time away from work or other responsibilities. We generally schedule new patients coming from out of town, or international patients, to initially meet with us on a Thursday. At that time, I review their medical history, performed my examination and evaluation, and begin treatment sessions that day. The initial three infusion sessions are given on Thursday-Friday-Saturday of the week you are with us. So you can get back to work and family on Monday morning as usual.
Is ketamine infusion therapy addictive?
No...it is not addictive, and it is safer than many prescribed medications
Not one of our patients has displayed or reported any symptoms of addiction. We have utilized the RESTORE Infusion to treat addiction or opioid dependence as it is remarkably effective in preventing withdrawal symptoms and medication craving. Current research indicates that ketamine may effectively combat alcohol, heroin, and cocaine addiction, which is an avenue that we may be actively pursuing in the future.
Do I need a referral for RESTORE therapy?
No, but we will review your medical records.
You do not need a formal referral from your treating physician. However, we will need to obtain your medical history and recent treatment notes from your treating physician. In addition, we will also need to get a brief chronic pain and depression assessment.
All of the information is then collected, and I review it personally to determine if you are an appropriate candidate for the infusion. Once that is completed, we can schedule your visit with us.
Do I need to bring someone with me to my RESTORE treatments?
If you can... it's a good idea, but not required.
Although you do not need to have someone bring you or remain with you during the infusion, a competent adult must bring you home. We advise you not to drive a car, operate heavy/dangerous machinery, sign any contracts, or partake in other potentially risky activities until the following morning.
If you do not have someone who can come with you, we can arrange, with our Hyatt Place partners, for safe transportation to and from our Center for your infusion sessions.
Can I eat or drink before my appointment?
You cannot eat solid food for 6 hours before your scheduled appointment. You may have clear liquids such as water, clear broth, apple juice, or clear tea/coffee (no milk or leaves) up to 2 hours before your appointment.
How much does it cost?
The RESTORE Ultra-Rapid Infusion is less expensive overall than the standard ketamine infusion.
Unfortunately, healthcare insurance companies uniformly regard this breakthrough form of therapy as "investigational" instead of what it truly represents as "innovative" and use that as the reason they do not cover it. We hope that will change someday as they realize this remarkable therapy's tremendous benefit and cost savings. I understand that cost is always a factor in these decisions, so it's essential to obtain all the information.
While we offer what is commonly known as the "standard ketamine infusion," the vast majority of our patients prefer the RESTORE infusion because it is more rapidly effective and longer-lasting. The "standard ketamine infusion" is commonly used by other ketamine centers and was initially developed at Yale and the National Institute of Health in 2000-2006. Nationally, the average cost for a typical ketamine infusion ranges between $500-$600.00 per infusion but varies depending on your location.
Our standard ketamine Infusion requires 6 infusions given every other day over two weeks and costs $2650.00 for the complete treatment, including the initial evaluation. Each maintenance infusion is $400.00 per infusion. Although it appears to be less expensive than RESTORE, the initial time commitment can be a barrier. The fact that you will require ongoing treatment each month can become very expensive for many people. Also, please be aware that the standard infusion is not significantly effective for fibromyalgia or migraines and cannot treat chronic neuropathic pain conditions.
RESTORE Essential Ultra-Rapid Infusion program is a significantly more advanced version of ketamine-based infusion therapy. It works 4 times faster than ketamine and has the additional benefit of achieving rapid long-term relief after just 2 maintenance sessions. After the initial series of 3 infusions, patients only require maintenance infusions at the three-month mark and the 6-month mark to have a long-term benefit (1-3 years or more) - in other words - complete remission. The cost for each maintenance infusion is $725.00, and it is also performed over 3 consecutive days and costs $3450.00 for the entire treatment.
The advantage of the RESTORE Ultra-Rapid Infusion is that it is faster, more effective, and longer-lasting. Patients do not need to return on an ongoing basis for more infusions as required with the standard ketamine infusion. In addition, the RESTORE Infusion can successfully treat not only mood disorders but also migraines, fibromyalgia, and certain forms of chronic pain.
Most of our patients request the RESTORE Infusion due to the advantages it provides, but we do see
patients that have benefited from the standard infusion and wish to continue with what was effective for them.
In terms of insurance coverage, while we hope that insurance companies will begin to cover this service in the next 1-2 years, now they do not. To help our patients, we do provide them with a medical invoice to help them recover some of the costs.
Now you can see why the RESTORE Infusion is less expensive than ketamine infusions.
What kind of payment do you accept?
We accept all major credit cards and cash. We have approached Care Credit to assist our patients with any of their financing needs, but so far they have declined to provide this service. But we hope that they will reconsider, please feel free to call them and ask.
Learn more about the doctor who developed and administers RESTORE
It's just as important that you know who is administering your infusion and how much knowledge and expertise they have in the field, so learn a little more about us.
It's time to get your life back and be Restored!...
The RESTORE Ultra-Rapid Infusions
We look forward to speaking with you!
Call - 800.850.6979
Consult with our experienced team to determine if RESTORE is right for you. Call us today or submit this request for a confidential consultation.