Transforming Lives with Ketamine Therapy
The KRI Mini-Fellowship: Beyond Certification—Toward Clinical Mastery
Adding ketamine therapy to your practice isn’t just a procedural shift—it’s a clinical, ethical, and strategic decision that demands more than just an online or weekend introductory course. The KRI Mini-Fellowship is the only ketamine training program in the U.S. that fully meets the American Psychiatric Association and American Society of Anesthesiology standards, and it’s built to do one thing: ensure you're prepared to deliver safe, effective, and outcome-driven ketamine care from day one.
A Program Designed for Clinicians Who Want to Do It Right
Many programs teach the basics. Few prepare you for real-world complexity. Most rely on outdated, standardized dosing protocols that lead to suboptimal outcomes—where fewer than 40% of patients improve, and up to 8% worsen. We teach a different approach: individualized, precision-based care informed by pharmacokinetics, metabolism, comorbidities, and real-time clinical observation.
What You Gain—Clinically and Professionally
➤ Mastery Through Experience and Mentorship
Spend three intensive days at our infusion center learning hands-on from expert faculty. Then, continue refining your practice with 12 months of direct support, including clinical consultations, business guidance, and mentorship. You're not left to figure it out alone.
➤ Clinical Tools That Actually Work
Receive comprehensive, ready-to-use protocols, evaluation templates, safety checklists, SOPs, and a proprietary pharmacokinetic dosing calculator—everything needed to safely launch or optimize your program without guesswork.
➤ Techniques That Set You Apart
Go beyond the outdated 0.5 mg/kg model. Learn target-determined infusions, genetic and lab-guided adjustments, and strategies to mitigate adverse effects—allowing you to consistently deliver better outcomes and gain more referrals.
➤ A Unique Patient-Centered Perspective
Unlike other programs, you’ll also personally experience a ketamine infusion under supervision. This rare opportunity fosters empathy, insight, and a deeper understanding of the patient journey, ultimately translating into stronger therapeutic alliances.
➤ Recognition That Follows You
Graduates earn KRI certification, a listing in our national clinician directory, and access to a network of peers committed to excellence in ketamine therapy—adding instant credibility to your practice.
It positions you not just to offer ketamine therapy—but to offer it safely, skillfully, and successfully, with the kind of confidence and outcomes that elevate both patient care and your professional standing.
Your Next Patient's Breakthrough Begins With Your Decision Today
Don't let another patient leave feeling hopeless when you can offer a genuine transformation. Join forward-thinking clinicians who are redefining what's possible in mental healthcare. And build the practice you've always envisioned, where your expertise creates life-changing results and hope.
Because your patients deserve transformation, not mere maintenance.
Apply Now for the Mini-Fellowship
Mastering Ketamine Therapy: Advanced Precision Medicine-Based Training
The Premier Ketamine Therapy Training Course for Clinicians
Transform Your Practice with the Only Training Program That Teaches Beyond Outdated Protocols
If you’re an MD, DO, NP, or CRNA seeking to revolutionize your practice and establish yourself as an expert in ketamine therapy, look no further. The Ketamine Research Institute’s "Mini-Fellowship" Intensive Training Program is not just another ketamine course—it’s the definitive pathway to clinical excellence, patient satisfaction, and professional recognition in this rapidly evolving field. The Mini-Fellowship Intensive is the most advanced and comprehensive ketamine training available—designed for clinicians serious about mastering precision-based, high-impact therapy.
Unlike online-only courses, this program provides a comprehensive blend of didactic instruction, immersive hands-on clinical experience, and personalized mentoring. Clinicians are trained using a cutting-edge approach to Personalized Medicine and Targeted Infusion Therapy, learning not only the fundamentals but also advanced pharmacokinetic modeling, precision dosing, and patient-tailored protocols. This ensures you can deliver safer, more effective, and better-tolerated treatments, setting your practice apart from typical "one-size-fits-all" protocols.
The Critical Choice Every Ketamine Practitioner Must Make
While most training programs continue teaching the antiquated "one-size-fits-all", 0.5 mg/kg protocol—a method that fails 30-50% of patients—forward-thinking clinicians are achieving superior outcomes through precision-based ketamine therapy. The question isn't whether ketamine works; it's whether you're delivering it with the sophistication that modern medicine demands.
The Stark Reality: The widely taught "standard" protocol was never subjected to FDA testing and rests on five scientifically disproven assumptions that systematically compromise patient outcomes and practice success.
Why Standard Training Programs Are Failing Clinicians
The Evolution of Ketamine Treatment Protocols
As ketamine therapy transitions from experimental treatment to mainstream psychiatric care, the clinical landscape demands more sophisticated approaches than traditional weight-based dosing. Leading practitioners are achieving superior outcomes through individualized, pharmacokinetically-guided protocols that address the inherent limitations of standard infusion methods.
Clinical Challenges with Current Standard Protocols
The widely adopted "one-size-fits-all" 0.5 mg/kg dosing protocol, which many training programs still teach, while historically significant, is outdated and significantly flawed, presenting several clinical limitations that impact treatment efficacy. The protocol's fundamental flaw lies in its reliance on five scientifically unsupported assumptions, including:
Pharmacokinetic Variability: Patients with identical body weights exhibit substantial differences in central volume of distribution, leading to variations in plasma concentration of up to 100%. This variability directly correlates with therapeutic response and adverse event profiles.
Individual Patient Factors: The standard protocol does not account for:
Genetic polymorphisms affecting ketamine metabolism (CYP2B6, CYP3A4)
Concurrent medications influencing pharmacokinetics and pharmacodynamics
Comorbid conditions affecting drug effects, metabolism, distribution, and clearance
Patient Metabolism, including age, gender, and hormonal factors impacting therapeutic response
What Has Been The Result?
This antiquated approach results in up to 25% of patients experiencing adverse effects and discontinuing treatment, 25% receiving inadequate therapeutic benefit, and often less than 50% achieving optimal response.
The protocol was never subjected to rigorous FDA testing or large-scale clinical validation; yet, it was adopted without testing and became a standard practice without scientific justification.
Advanced Training Curriculum: Precision Ketamine Therapy
Advanced Training Curriculum: Precision Ketamine TherapyOur comprehensive training program addresses these clinical challenges through evidence-based and experience-proven methodologies.
Modern ketamine therapy demands individualized, pharmacokinetically guided dosing that accounts for patient-specific variables to optimize therapeutic outcomes while minimizing adverse effects and treatment failures.
The ketamine therapy market is rapidly maturing. Patients are becoming more sophisticated, insurance coverage is expanding, and competition is intensifying. Clinics using outdated protocols will increasingly struggle against those employing precision medicine approaches that deliver consistently superior outcomes.
While your other ketamine centers continue using protocols that were never subjected to FDA testing or rigorous clinical validation, our advanced training positions you to offer scientifically superior care, including:
Individualized Dosing Strategies
Pharmacokinetic modeling for optimal plasma concentration targeting
Patient-specific assessment protocols
Precision dosing calculations based on individual physiology
Clinical Decision-Making Framework
Drug interaction assessment and protocol modifications
Comorbidity-specific treatment adjustments
Genetic and metabolic factor integration
Enhanced Safety and Efficacy Protocols
Advanced monitoring techniques
Adverse event prevention strategies
Optimization methods for treatment-resistant cases
Professional Development Benefits
Clinical Excellence: Master advanced techniques that optimize therapeutic outcomes while minimizing adverse events, positioning your practice as a center of excellence in ketamine therapy.
Competitive Differentiation: Implement precision medicine approaches that distinguish your practice through superior patient outcomes and enhanced safety profiles.
Practice Growth: Achieve higher patient satisfaction scores, improved treatment success rates, and enhanced word-of-mouth referrals through evidence-based methodologies.
Professional Recognition: Join a network of clinicians utilizing cutting-edge protocols that represent the future of ketamine therapy.
Evidence-Based Curriculum
Our training methodology is grounded in current pharmacological research and clinical best practices, moving beyond empirical approaches to embrace precision medicine principles that are becoming the standard of care in advanced psychiatric practices.
Who will this training program benefit
This advanced training is designed for healthcare providers seeking to:
Optimize treatment outcomes through individualized protocols
Implement evidence-based safety measures
Enhance clinical decision-making capabilities
Advance their expertise in ketamine therapy
Professional Commitment to Excellence
As ketamine therapy continues to evolve, staying current with advanced methodologies ensures optimal patient care and maintains your position at the forefront of psychiatric innovation. Our training equips you with the knowledge and skills necessary to deliver the highest standard of ketamine therapy in today's competitive healthcare environment.
Leading the Future of Precision Ketamine Therapy
Our program and approach are more than training—it’s a transformation. It offers an unmatched clinical education that distinguishes you as a leader in ketamine therapy. Become the go-to expert in ketamine therapy, trusted by peers and sought out by discerning patients.
The Mini-Fellowship Training Program offers rigorous clinical knowledge, practical skills, and access to a global network of respected professionals. Gain the confidence and credentials to speak at conferences, publish, and mentor others in this rapidly growing specialty. Position yourself as a trusted authority, ready to lead colleagues and patients alike into the new era of medical therapeutics.
Ready to advance your career, expand your impact, and lead in the field of transformative medicine? Join us in the only program that combines personal ketamine experience, hands-on clinical training, and advanced precision medicine techniques in one comprehensive package.
Our Invaluable Tools for Success in Ketamine Therapy Include:
The Complete Clinical Reference Manual of Ketamine: From Theory to Practice
The Ketamine Research Institute training manual represents a comprehensive compendium of advanced ketamine knowledge, authored by Dr. Gerald W. Grass, MD, Medical Director of KRI. The manual serves as an invaluable reference source, consolidating cutting-edge research, pharmacokinetic principles, and a mechanistic understanding of ketamine's complex therapeutic actions across multiple clinical applications.
Your Desk Companion for Ketamine Therapy
The manual serves as both an educational resource and a detailed pharmacological reference, covering advanced topics such as NMDA receptor antagonism, neuroplasticity mechanisms, and the metabolite pathways of ketamine. It contains an in-depth analysis of dosing pharmacokinetics, drug interactions, contraindications, and the intricate relationship between ketamine's dissociative and antidepressant properties. For clinicians working with ketamine therapy, this manual serves as a critical desk reference for understanding the sophisticated pharmacological principles underlying this versatile therapeutic agent, making it an essential resource for evidence-based clinical decision-making.
The Ketamine Research Institute Clinical Companion That Transforms Ketamine Care
The Ketamine Research Institute Clinical Companion App is a point-of-care digital tool that transforms the advanced principles of the KRI Mini-Fellowship into practical, bedside support for clinicians. It combines precision dosing calculators based on the Clements 250 PK model with real-time infusion simulation curves, integrating the “5 M’s” of ketamine effectiveness—mass, medications, morbidity, metabolism, and mindset—to deliver target-determined infusions personalized to each patient. The app streamlines patient evaluation with selection checklists and contraindication alerts, incorporates genetic and metabolic considerations such as CYP450 and BDNF variants, and provides condition-specific plasma concentration targets for depression, PTSD, anxiety, and chronic pain.
The Clinical Companion Promotes Patient Safety and Efficacy
To ensure safety and compliance, it includes built-in documentation templates, logbook tools, and quick reference guides aligned with APA, ASA, and DEA standards. Acting as a digital mentor, safety safeguard, and performance optimizer, the Clinical Companion App empowers clinicians to achieve superior outcomes, reduce risk, and bring the whole precision medicine approach of KRI directly into daily practice.
Ketamine PLUS: The Clinician’s Marketing Handbook
Establishing Professional Excellence and Recognition in Ketamine Therapy.
This comprehensive marketing strategy manual empowers KRI fellowship-trained clinicians to establish themselves as recognized experts in advanced ketamine therapy while ensuring the highest standards of patient care and professional practice. By implementing the evidence-based communication strategies outlined in this guide, you will effectively differentiate your personalized medicine approach from standard protocols, helping patients and referring physicians understand the superior safety profile and clinical outcomes achieved through pharmacokinetic modeling, individualized dosing, and continuous monitoring protocols.
The manual provides ethical frameworks for communicating your advanced training credentials, clinical expertise, and commitment to exceeding APA and ASA recommendations, positioning you as the preferred provider for treatment-resistant patients who require sophisticated medical intervention beyond conventional approaches.
Be Recognized as a Ketamine Expert
The systematic implementation of these professional marketing principles directly supports improved patient outcomes by ensuring that individuals requiring advanced ketamine protocols can identify and access your specialized services. Through targeted educational content, professional networking strategies, and evidence-based messaging, you will build a referral network of healthcare providers who understand when to recommend personalized ketamine therapy over standard treatments, ultimately improving treatment success rates and patient safety in your community.
This approach not only establishes your reputation as a clinical expert committed to the highest standards of care but also ensures that your practice operates in full compliance with professional guidelines while serving patients who have exhausted traditional treatment options and require the sophisticated, individualized protocols that only KRI-trained specialists can provide.
Complete Implementation Package: A 110-page strategy manual featuring evidence-based frameworks, professional communication templates, and systematic approaches for establishing clinical expertise while upholding the highest standards of patient care and professional compliance.
Investing in Excellence: The Value of Intensive Hands-On Fellowship
More Than That...This program offers exclusive features not found anywhere else, including:
Enhanced Patient Selection Protocol - Master our proprietary screening methodology that goes beyond basic contraindications to identify ideal candidates, dramatically improving success rates and reducing adverse outcomes
Pre-Infusion Evaluation and Optimization Program - Learn our systematic patient preparation protocols that optimize treatment readiness through targeted interventions, ensuring maximum therapeutic benefit from each session
- Precision Medicine Protocols - Master genetic-based dosing strategies that incorporate MTHFR, BDNF, and CYP450 variations for personalized treatment optimization.
- Hands-On Clinical Training - Perform actual ketamine infusions under expert supervision in our operational clinic, gaining real-world experience impossible to replicate online
- Personal Ketamine Experience - You'll undergo a supervised ketamine infusion yourself, gaining invaluable firsthand insight into your patients' journey that transforms your treatment approach and patient selection abilities.
- Target-Controlled Infusion (TCI) Mastery - Learn advanced pharmacokinetic modeling for precise plasma concentration targeting, moving beyond crude weight-based dosing to true precision medicine
- Elite Small Cohorts - A maximum of 4 participants per program ensures personalized, one-on-one mentoring, as opposed to the unlimited online enrollment found elsewhere.
- Comprehensive Mentorship - Ongoing individual guidance transforms you into a recognized authority on ketamine, not just another provider.
Whether you're just starting or seeking to enhance your current practice, this training equips you to deliver superior outcomes safely and confidently. Plus, with a full year of professional mentorship, you’ll have the ongoing support needed to master this groundbreaking treatment.
Click Here to Apply for Training
Your Success with Ketamine Therapy Hinges on Choosing the Right Training Program
The increasing popularity of ketamine therapy has led to a proliferation of training programs. However, the quality of these offerings varies widely, leaving clinicians—particularly those new to ketamine—struggling to identify programs that provide the depth and rigor needed to ensure safe, effective treatment. Many programs lack a unified, evidence-based curriculum, instead relying on multiple instructors with varying levels of expertise. This fragmented approach can yield subpar outcomes for both clinicians and patients.
Many Training Programs Rely on Outdated Ketamine Protocols.
Setting Your Patients Up for Failure:
What many clinicians do not realize is that the 0.5 mg/kg - "One-Size-Fits-All" Protocol is Flawed in Actual Practice:
Many existing ketamine training programs continue to teach outdated, standard infusion protocols, including the conventional 0.5 mg/kg dosing recommendations, which were never subjected to large-scale clinical testing. These protocols often rely on a one-size-fits-all approach, resulting in imprecise dosing that frequently leads to under- or overdosing in real-world patients.
This can result in therapeutic plasma levels that are either too low to produce efficacy or too high, increasing the risk of adverse effects. As research studies continue to show, such approaches lead to poor and inconsistent treatment outcomes, with many patients experiencing minimal benefit or discontinuing treatment altogether.
Clinicians trained in these outdated protocols may unknowingly perpetuate these same suboptimal outcomes, leaving both themselves and their patients at a distinct disadvantage in a rapidly evolving field of precision medicine. By choosing programs that still adhere to these imprecise guidelines, clinicians risk not only compromising their practice but also providing substandard care that falls behind the latest advances in ketamine therapy.
Outdated Ketamine Protocols = Disappointing Results: Are You Setting Your Patients Up for Failure?
While high-quality research studies report impressive results for ketamine therapy, real-world outcomes often fall alarmingly short. Studies show that less than 50% of patients experience significant improvement in symptoms when treated in community-based settings, and up to 8% may experience worsening symptoms (McInnes et al., 2022; Sakurai et al., 2020; Wilkinson et al., 2018).
In addition, many patients fail to complete the induction series or discontinue treatment prematurely, with up to 47% dropping out due to adverse effects or insufficient improvement (Kumar, PS. et al., 2024). Worrisome, too, are reports that some patients may not only experience a worsening of their symptoms but report becoming suicidal after treatment (McInnes et al., 2022;), further emphasizing the need for rigorous, evidence-based training to minimize these risks.
These discrepancies are often due to inadequate clinician training, inconsistent protocols, and insufficient patient preparation or follow-up care. Such shortcomings not only undermine the potential of ketamine therapy but can also harm its reputation as a transformative treatment.
The New Gold Standard in Ketamine Training
What Sets Our Program Apart From All Others:
What Sets Our Program Apart From All Others:The KRI "Mini-Fellowship" Intensive Training Course is an unparalleled, cutting-edge program designed for clinicians aspiring to specialize in ketamine infusion therapy. Our program is the only one in the U.S. that not only meets but exceeds the rigorous training recommendations set by the American Psychiatric Association and the American Society of Anesthesiologists. What truly sets us apart is our commitment to delivering advanced training in the pharmacokinetics of ketamine therapy, empowering you to provide more effective, safer, and better-tolerated treatments for your patients.
Additionally, we are the only program that offers supervised clinical experience, allowing you to gain hands-on expertise under the guidance of seasoned professionals. We also provide the unique opportunity to experience a ketamine infusion personally. This invaluable experience gives you the insight and knowledge to make more informed decisions when selecting and treating your patients.
Beyond our comprehensive curriculum, we are dedicated to your long-term success. Our graduates benefit from ongoing personalized mentoring and professional consultation, ensuring you are never alone in navigating this rapidly evolving field.
Stand out as an actual "Ketamine Expert" and not just another "Ketamine Clinic"
Our training program is not just a step towards opening a "ketamine clinic" but a comprehensive educational journey that empowers you to become a "true expert" in the field. By choosing our program, you are investing in the advanced skills, knowledge, and professional development necessary to excel in ketamine therapy, setting yourself apart in a crowded marketplace of "ketamine clinics" and ensuring the highest quality care for your patients.
Become one of the Top 100 Ketamine Clinicians
In an era where mental health treatment demands innovation and precision, mastering ketamine therapy through advanced Precision Medicine training represents a transformative step forward for clinicians. Our innovative training methodology arms practitioners with the most advanced precision medicine techniques, essential clinical skills, and "hands-on" experience necessary to become experts in ketamine therapy.
This comprehensive preparation allows them to customize and tailor ketamine treatments with unmatched effectiveness and safety, setting a new standard in patient care. The "Mini-Fellowship" program is more than training; it's a transformational experience that positions you at the vanguard of personalized ketamine therapy.
It is our duty to provide expert, safe, effective care to our patients.
As clinicians, we are responsible for ensuring that our patients receive the highest quality of care. One of the most exciting developments in this regard is the increasing evidence for the efficacy of ketamine therapy for a range of psychiatric and chronic pain conditions. Research has consistently demonstrated that ketamine infusions can be an incredibly beneficial and effective treatment for conditions like depression, anxiety, PTSD, and chronic pain. Incorporating this treatment into your practice can provide your patients with a safe and effective treatment option.
However, as with any new therapeutic approach, ketamine infusion therapy requires specialized training to administer effectively and safely. Therefore, we encourage clinicians to obtain the necessary training to offer this service and to properly understand how ketamine works and the risks associated with its use. Practitioners can confidently offer ketamine therapy while providing patients with a safe and effective treatment option.
The future of medicine is here. By embracing ketamine infusion therapy in your practice, you will be at the forefront of a revolutionary approach to treatment and make a lasting impact on the lives of your patients and how we treat mood disorders and chronic pain.
New Advancements in Ketamine Therapy
Our advanced training course and mentoring programs are designed to equip clinicians with the knowledge and skills to deliver safer and more effective ketamine therapy, achieving up to 50% greater effectiveness and 90% higher patient compliance rates compared to other community providers. Our course goes beyond the limited pharmacological concepts of the standard ketamine infusion protocol, expanding into target-controlled infusions and precision medicine to unlock the full potential of ketamine therapy for patients.
The Cutting-Edge Treatment You Need to Know About:
Ketamine Infusion Therapy with Precision Medicine and
Target-Controlled Infusions
If you are a clinician interested in providing ketamine-based therapy to your patients but don't feel confident in your ability to do so safely and effectively, consider enrolling in KRI's "Mini-Fellowship" program. This intensive training program complies with all APA and ASA professional recommendations for training in ketamine therapy.
It will provide you with everything you need to use ketamine therapy safely and effectively in your practice - from didactic lectures led by expert educators to hands-on clinical experiences at a fully operational infusion center. You'll also have access to ongoing personal mentoring from experienced clinicians throughout the program and beyond.
Our Goal - Train Future Ketamine Experts in the Field
Our goal is to train the Top 100 Ketamine Clinicians in the United States. Our graduates will become leaders in their field, highly respected ketamine experts, and serve as professional examples of clinicians providing the safest and most effective ketamine therapy available.
Proper didactic and clinical training is vitally important as ketamine therapy is recognized as an effective treatment modality for mood disorders. Authors of the American Psychological Association (APA) Consensus Guidelines for ketamine therapy have suggested an alarming lack of adherence to safety guidelines among providers, creating a potential risk to patient welfare. Their estimations indicate that only a small portion - less than 5% - of ketamine providers adhere to the selection, evaluation, and safety standards.* This disconcertingly small number may be a sign that much of the ketamine treatment being provided in local clinics is not meeting essential safety standards, potentially creating risk to patients who receive care.
The "Mini-Fellowship" training program has been developed to ensure that high standards and effective treatment in ketamine therapy are maintained. Our intensive training program provides practitioners with the most up-to-date, evidence-based, and experience-proven education and training in ketamine therapy, as well as supervised clinical experience administering ketamine therapy and personalized mentorship, ensuring that the highest standards are met.
Understand the Basics of the Standard Ketamine Protocol — Then Take it to the Next Level.
Our training course is designed to provide clinicians with a comprehensive and superior understanding of ketamine therapy, including the evolution and development of the standard ketamine infusion, as well as its inherent limitations. The standard ketamine infusion has gained attention recently as a potential treatment for mood disorders such as depression and anxiety. However, it is becoming increasingly clear that when this treatment is removed from a controlled research environment and applied in community practice, its effectiveness is not as high as initially suggested by research studies.(references: 1, 2, 3 ,4, 5)
The Imprecise and Highly Variable Nature of Standard Ketamine Therapy
This can be attributed to several factors, including the lack of personalized dosing strategies and a failure to consider individual patient variations. Standard dosing regimens, such as those based on a fixed mg/kg dose per body weight, do not account for variations in body mass, volumes of distribution, or variations in CYP450 metabolic pathways. These variations can significantly impact the pharmacokinetics of the medication and, consequently, the effectiveness of the treatment.
Our advanced training course extends beyond the standard ketamine infusion protocol's limited selection criteria and pharmacological concepts. It expands into rigorous patient selection and evaluations, combined with target-controlled infusions and precision medicine, to unlock the full potential of ketamine therapy for patients. By considering individual variations and tailoring treatment to each patient, our graduates possess the knowledge and skills to deliver safer and more effective care, informed by the latest research and pharmacological approaches.
Precision Medicine and TCI for Ketamine: Achieve Up to 50% Greater Effectiveness
Clinicians trained by us can be confident that they possess the skills necessary to deliver ketamine therapy successfully, following all recommended professional guidelines, with up to 50% greater effectiveness and 90% higher patient compliance rates compared to other community providers. (references: KRI Study)
The "Mini-Fellowship" Intensive Ketamine Training Program for Clinicians
The Ketamine Research Institute is at the forefront of ketamine infusion therapy and physician education, offering our innovative ketamine infusion training programs. We’re on a mission to accelerate the healthcare revolution. We have pioneered ketamine infusion therapy to bring the latest breakthrough discoveries about ketamine, Precision Medicine, and Target-Controlled Infusions out of the research lab and into our infusion centers and training programs.
About Our Program
The Ketamine Research Institute (KRI) has developed an advanced and intensive educational program specifically designed to train clinicians in the safe and effective use of ketamine-based therapy for mood disorders - the "Mini-Fellowship" Intensive Training Program for Clinicians. KRI's curriculum is based on best practices and evidence-based treatment protocols established by leading clinicians in the field. The program is designed for both novice and experienced practitioners to gain essential skills that will enable them to confidently and competently administer ketamine-based therapy in their practice.
The program provides everything you need to become a highly qualified and proficient clinician in ketamine-based therapy. Our training program offers a comprehensive educational experience that includes didactic lectures, interactive discussions, case studies, and "hands-on" clinical experience at a fully operational ketamine infusion center. We also provide you with the unique opportunity to personally experience what it feels like to undergo a ketamine infusion. This valuable experience can be profound and provide you with valuable insights into the "phenomenology" of the ketamine experience, which can be crucial when working with patients receiving this remarkable new therapy.
Additionally, we will provide you with one year of personal mentoring as you establish your ketamine practice, ensuring that your program runs smoothly from its inception. Graduates of our training program also become part of our extensive patient referral network, an exclusive group of highly trained and qualified clinicians dedicated to helping those in need access safe, effective ketamine infusion therapy.
Experienced experts in the field of clinical ketamine research and therapy designed our program. It incorporates the latest advances in our understanding of how ketamine works, as well as new approaches, protocols, and techniques to enhance the effectiveness of ketamine therapy. We are confident that no other training program in the United States can provide the depth, clinical experience, and sophistication required to become a highly skilled provider of ketamine therapy than the Ketamine Research Institute.
Please consider joining us - we look forward to working with you!
Click here for the 2026 Course Schedule and Application
Learn More About Ketamine Therapy for Mood Disorders
Ketamine Therapy Gains Recognition
Ketamine infusion therapy is an exciting new development in the world of psychiatry. It has shown great promise in the treatment of a variety of mental health conditions, including depression, bipolar disorder, anxiety, and post-traumatic stress disorder (PTSD).
During the recent COVID epidemic, depression, anxiety, and post-traumatic stress disorder rates have all risen dramatically. Media outlets have been educating the public about the tremendous therapeutic benefits of ketamine and other psychedelics for the rapid relief of mood disorders and related conditions.
Health insurance companies in both Canada and the U.S. have taken notice and may soon start covering ketamine-based therapy treatments. As awareness grows around this new treatment breakthrough, many more people who suffer from mental health issues will be able to benefit from ketamine-based therapy that has been proven to be effective.
The Need For Well-Trained Ketamine Clinicians
The Rise of "Ketamine Clinics"
Ketamine-based therapy is increasingly recognized as a rapid and highly effective treatment for mood disorders — with success rates that exceed 75% or more — and patients who haven't received help from conventional approaches are demanding new treatment options. Unfortunately, to meet this new demand the number of questionable "ketamine clinics" and "at-home" ketamine services has also risen.
Despite its effectiveness in treating mood disorders, the "one-size-fits-all" ketamine therapy approach employed by many clinics cannot replicate the same level of relief seen in controlled clinical studies. Moreover, some treatment centers may not provide sufficient preparations to patients or adhere to strict patient selection criteria as medical organizations recommend, leading to less-than-optimal results.
Unfortunately, various commercial interests are attempting to "expand the accessibility" of ketamine therapy by treating patients remotely and providing them with nasal sprays, lozenges, and pills that contain ketamine to use at home. Despite its potential for profit gain, this practice is strongly opposed by experienced clinicians and professional organizations because of its lack of credible, evidence-based efficacy and potentially hazardous side effects.
Various elements have caused these issues to arise, but inadequate education and training in ketamine therapy among some professionals have substantially contributed to this dilemma.
Lack of Adequate Training
Sadly, too many clinicians may have taken shortcuts for various reasons and not sought adequate training programs before starting ketamine therapy. This could be due to the apparent simplicity of the ketamine infusion, which lulled some clinicians into thinking that formal training may not be necessary. However, ketamine therapy is unlike any other medical procedure and has many complexities and unique aspects, something that many without adequate training fail to recognize.
Poor Training Leads to Poor Outcomes
Although most ketamine providers cite research studies indicating that up to 70-75%% of people can improve following ketamine therapy, recent studies have shown that ketamine may not be nearly that effective when it is given by clinicians in a community ketamine clinic setting. Some believe a more realistic number would be only 35-45% of people respond to ketamine infusions when it is given in an outpatient ketamine clinic or center.(references: 1, 2, 3, 4, 5)
These subpar outcomes may result from a lack of adequate training, experience, or understanding of the unique aspects of this remarkable but complex treatment. Not only are the outcomes much poorer, but there was also an increasing number of adverse effects, and potential patient safety issues were noted. This has prompted professional organizations such as the American Psychiatric Association to make recommendations emphasizing the importance of obtaining proper ketamine-based training before offering ketamine therapy to patients.
This Causes Concern for All
In fact, according to the authors of the American Psychological Association (APA) consensus guidelines, it is estimated that fewer than 5% of ketamine providers adhere to the standards for selection, evaluation, and safety recommendations. This is a cause for concern, as deviation from these guidelines and the evidence provided by randomized controlled trials and long-term follow-up studies may put patients at increased risk. One author states, "the further we deviate from established standards, the greater the risk to patients." (reference: 6)
Professional Organization Recommendations
To ensure the safe and successful use of ketamine, clinicians offering any form of care must be properly trained and educated. To help meet this growing demand, in 2017 the American Psychiatric Association (APA) released Consensus Guidelines outlining the qualifications and comprehensive training necessary to provide health professionals with the tools they need to safely and effectively use ketamine-based therapy in their practices.
In addition, states are beginning to pass strict laws regarding the safe use of ketamine for the treatment of mood disorders, such as the one passed recently in Utah (UT-58-1-510), which will directly impact ketamine centers not only in Utah but in other states as similar measures are adopted.
Those recommendations included the need for didactic educational training and "hands-on" clinical experience administering ketamine infusion therapy under the supervision of more experienced clinicians. This would allow practitioners to gain an intellectual understanding of ketamine therapy and develop the essential skills and techniques necessary to become proficient in the safe administration of ketamine to their patients.
Also, practitioners need to be aware of new laws regarding the strict avoidance of moderate to deep sedation while using ketamine and be trained in appropriate airway management techniques.
Training Programs Vary Greatly in Content and Quality
Many organizations are offering ketamine training, but the quality of these programs varies. Clinicians who are new to ketamine therapy and seeking education may find it difficult to determine which ones are reputable and offer comprehensive instruction. Often, the programs are led by multiple clinicians with varying levels of clinical knowledge and experience. This can make it very difficult to form a cohesive and adequate understanding of ketamine therapy.
It is essential to look for programs that offer all of the training components recommended by the APA, including didactic education, supervised clinical training, and individual mentoring. Any program offering ketamine-based therapy training should also include real-world experience administering ketamine therapy under the close supervision of more experienced clinicians.
Online Programs versus Actual Clinical Training
On-Line Programs
Many training programs are being conducted "online" and have the apparent advantage of offering inexpensive, convenient, on-demand modules for training. Although this format is appealing, pre-recorded online program modules can't answer important questions that often come up during training sessions. In addition, they do not provide any form of supervised "hands-on" instruction as recommended by the APA. Lastly, they do not offer ongoing personal clinical guidance after the course to assist you as you begin your infusion program.
Clinical Training Programs
On-site clinical training programs are usually more expensive but provide an optimal environment for learning about ketamine therapy. Participants benefit from receiving in-depth instruction and direct guidance from experienced clinicians. This type of program meets all professional organizations' (APA and ASA) recommendations for training. Also, it allows for personalized mentoring and coaching after completion of the course so that clinicians can be sure they adhere to best practices when administering ketamine to their patients.
Furthermore, many medical liability insurance companies recommend or may require this training for their clinicians to be adequately covered and insured. This is because they recognize that these courses provide the highest level of education, with participants receiving comprehensive instruction and direct contact with experienced practitioners knowledgeable in ketamine therapy.
Consequently, investing in an on-site ketamine therapy training course is an excellent way for clinicians to understand the procedure and its potential therapeutic benefits thoroughly. Furthermore, completing this type of intense educational experience can help ensure that practitioners practice safely and responsibly when administering ketamine to their patients.
Few Options Exist
Unfortunately, very few training programs are available that have qualified and experienced ketamine clinicians who can provide this level of comprehensive educational training experience and supervised clinical training in the setting of an operational ketamine infusion center.
That is the advantage of the Ketamine Research Institute's "Mini-Fellowship" in ketamine-based therapy. This is not a simple online course but an opportunity for clinicians to come and spend several days with us in an immersive learning environment - an actual ketamine infusion center. This type of training is certainly more intensive and expensive, but the education, experience, ongoing support, and mentorship you receive are invaluable.
Ketamine Research Institute is Leading The Way in Clinician Training
Our Experience and Qualifications
Gerald W. Grass, MD - Medical Director
The "Mini-Fellowship" Intensive Training Program for Clinicians is a sophisticated and advanced training program that results from over 35 years of clinical research and experience in ketamine practice. Over the past three decades, I have conducted clinical ketamine research and provided thousands of hours of continuously monitored ketamine infusions to individuals worldwide, gaining invaluable experience in various clinical circumstances. Our work has been presented at national conferences and academic and governmental institutions providing educational programs in the use and future application of ketamine therapy.
In addition, I have served as principal investigator for pharmaceutical companies engaged in Phase III drug trials for psychopharmacological agents seeking FDA approval and as clinical advisor to various organizations and biotechnology firms.
All of this experience is then distilled down and passed on to our attendees in the form of didactic lectures, small-group discussions, as well as hands-on opportunities to administer ketamine under direct supervision. We offer this wealth of experience and knowledge to participants in our program so they can return to their practices confident in their abilities to provide ketamine-based therapy safely and effectively. The bottom line is that we can provide you with the knowledge, experience, and skills necessary to be a well-respected and successful clinician providing ketamine therapy in your community.
Our Program is Unique Among Training Programs
The Ketamine Research Institute training program is one-of-a-kind, custom-tailored, and specific to the professionals' intended use of ketamine-based therapy. It is particularly well-suited for clinicians in the fields of Psychiatry, Primary Care, Integrative/Functional Medicine, and Emergency Medicine who are new to this modality and are interested in adding ketamine-based therapy to their practice as a rapidly effective treatment for various mood disorders, including depression, bipolar disorder, anxiety, and PTSD. Our program is one of the very few that comply with all APA and ASA recommendations for training in ketamine therapy.
All Training is conducted on-site in an Actual Infusion Center
Our training program is conducted "on-site" and "in-person" in our infusion center at the Ketamine Research Institute in Sarasota, FL, which allows you to become familiar with the environment where infusions are performed. Training in our infusion center provides you with the opportunity to gain "hands-on" experience performing infusions under supervision and to become familiar with all the necessary monitoring equipment, intravenous delivery systems, and supplies essential for the safe administration, storage, and handling of ketamine.
Precision Medicine and Target-Controlled Infusions
Our course provides a detailed understanding of the inherent but often overlooked intrinsic limitations of the standard ketamine infusion developed at Yale in 1994. This knowledge is critical to achieving the best therapeutic benefit for your patients. We employ a highly practical and "in-depth" approach to ketamine therapy, using basic and advanced principles of pharmacokinetics and pharmacodynamics that are not available in any other training program known as Ketamine PLUS. This includes a proprietary Precision Medicine and Target-Controlled Infusion approach to overcome limitations of the "standard" infusion and significantly improve the effectiveness of ketamine therapy — optimizing your ability to achieve success with your patients.
Training Excellence
We believe that providing safe, more effective, and better-tolerated ketamine infusion therapy is essential to becoming recognized as a highly skilled and successful clinician rather than just another "ketamine clinic." We are dedicated to helping clinicians become the specialists in this field that they strive to be through our comprehensive and intensive program.
Our mission is to provide clinically meaningful, evidence-based education and training to enable you to bring ketamine-based therapy safely and effectively into your practice — so you can make a more positive difference in the lives of your patients.
The Benefits of Our Program
Small Group - One-on-One Attention
We limit our course to three practitioners to facilitate a personal and tight-knit learning environment where everyone can actively participate and become comfortable with administering ketamine infusion therapy in an operational ketamine infusion center. While with us, clinicians have an opportunity to become familiar with and use all of the necessary monitoring equipment, venous access technologies, intravenous delivery systems, and supplies necessary for the safe administration, storage, and handling of ketamine.
Personalized To Your Needs
To the degree possible to maintain our educational objectives, the 3-day intensive training is customized to each practitioner's needs and skill level. It delves deeply into specialized aspects of ketamine pharmacokinetics and pharmacodynamics, including the effects of patient-specific metabolism, medication interactions, and genomic variables on ketamine metabolism and efficacy.
Our Advanced Didactic Component
Our specialized didactic training program is unlike any other available ketamine training. It offers clinicians not only comprehensive, in-depth, classroom-based instruction but also more advanced topics in the pharmacokinetic and pharmacodynamic aspects of ketamine therapy. In addition, we focus on a Precision Medicine and Target Controlled Infusion approach to ketamine therapy that increases its effectiveness in everyday "Real World" clinical applications.
The Necessary Hands-On Clinical Experience
Administering ketamine infusions safely and effectively requires a comprehensive understanding of how to personalize the dosing regimen, use precision medicine concepts, and tailor the infusion plasma concentrations of ketamine to achieve optimum therapeutic effects. Our clinical training guides you through administering ketamine while also providing the opportunity to learn the skills and techniques necessary to become highly proficient in this therapy.
The Ketamine "Experience" Component
Going a step beyond, we also encourage clinicians to personally experience what it is like to have a ketamine infusion. It is our experience that having a first-hand understanding of what ketamine feels like and how it affects cognition, mood, and behavior can be extremely helpful and provide valuable insights into the "ketamine experience" when working with patients who are receiving this remarkable new therapy.
Our Mentoring Program - Personal Guidance as You Begin
Our one-year Mentoring Program is an essential resource when beginning your ketamine infusion program and practice. We provide experienced guidance and support to ensure that your program runs smoothly from its inception. We advise on best practices for patient selection, dosage, treatment protocols, and more as you get started, to help ensure a safe, effective, and successful program that improves the lives of your patients. With our experienced mentoring, you can be sure to start your program on the right track.
Become a Member of Our Extensive Referral Network
Graduates of our training program become part of our extensive patient referral network. Each month, thousands of people contact us, searching for clinicians who are highly trained and qualified to perform ketamine therapy. Becoming part of this exclusive group provides additional exposure for your practice, enabling you to reach potential new clients searching for our qualified ketamine infusion experts dedicated to helping those in need access safe and effective ketamine infusion therapy.
Our Mission
The Ketamine Research Institute's mission is to train the next generation of healthcare providers in evidence-based best practices for administering safe and effective ketamine-based treatments. We are dedicated to providing clinicians with comprehensive training that is accurate, up-to-date, and clinically relevant.
Ketamine Research Institute Training Program Includes:
All The Recommended and Essential Components of Ketamine Training Are Provided:
1. Comprehensive didactic lectures covering advanced pharmacology, physiological effects, and clinical applications of ketamine.
2. Interactive discussions tailored to clinicians’ specific practice settings
3. Case studies and reviews of actual ketamine-based treatment protocols in real-world patients.
4. Hands-on experience administering ketamine infusions at a fully operational Ketamine Infusion Center.
5. The opportunity to gain valuable insights into the phenomenology of the ketamine experience by personally experiencing it for yourself.
6. Ongoing personal mentoring for six months from experienced ketamine clinicians as you begin your ketamine practice.
7. Plus, access to extensive resources, including additional educational materials, treatment protocols, our referral network, and more.
After the Course
After the program, clinicians will be certified by the Ketamine Research Institute as qualified ketamine therapy providers with supervised clinical experience. This certification is the first step in becoming a highly skilled and successful ketamine practitioner. We invite you to join our growing network of practitioners transforming patient care through evidence-based best practices.
We believe our program is exceptional and exceeds all recommendations, didactic and clinical, published by the American Psychiatric Association and the American Society of Anesthesiologists, and also includes the added benefits of an experiential component to understand and appreciate the uniqueness of ketamine infusion therapy fully. We are committed to helping clinicians learn how to provide these treatments safely and effectively.
Here's What Our Graduates Are Saying
"I thoroughly enjoyed the course and thought it was a good mix of science and practical knowledge. And of course, it was very helpful as I had no clinical experience with Ketamine and just a little knowledge from what I’ve read...
It gave me a clear road map moving forward. I’m sure there is a lot still to learn, but you never know what you don’t know until it arises....Having access to your forms and waivers, etc. is huge!...
No other training offers an actual infusion for us to experience what it’s like. Having done it now, I can appreciate how difficult it would be to explain it without having done it."
— David Smith, MD - Internist/Family Practice
To Learn More About Our Programs - please click the links below:
The "Mini-Fellowship" Intensive Training Program
A Detailed Course Overview
Day 1: Ketamine-Based Therapy: The Current State of Ketamine Therapy
Day 2: Ketamine-Based Therapy: Efficacy versus Effectiveness
Day 3: Ketamine-Based Therapy: The Precision Medicine Approach
Our 2024 Course Schedule and How To Apply For Training
The Origin of Our Ketamine Training Program
What Our Graduates Say About The Course
How the Ketamine Research Institute Training Program Complies with APA and ASA Recommendations
What Is Currently Needed.
There is a tremendous need for qualified medical professionals trained to provide patient-centered, safe, effective ketamine therapy for mood disorders. This 3-day intensive program aims to provide clinicians with the necessary skills, understanding, and knowledge to administer a superior and optimized ketamine infusion to their patients in an office or outpatient setting. The program covers all aspects of ketamine therapy that have practical clinical applications today and in the future.
Ketamine PLUS infusion therapy - Become a Certified Practitioner and licensed partner with the Ketamine Research Institute
After completing our training program, you will become eligible to become a certified Ketamine PLUS provider and licensed partner with the Ketamine Research Institute. This is an unparalleled opportunity for medical professionals and ketamine specialists looking to revolutionize their skills, expand their offerings, and provide the best possible care for their patients.
In passing the KRI's certification examination, you'll demonstrate your commitment to providing the highest level of care to your patients and solidify your position as a trusted and respected provider in the field of mental health treatment.
Don't miss out on this opportunity to elevate your medical practice and make a real difference in the lives of your patients. Join with the Ketamine Research Institute as a certified Ketamine PLUS provider and licensed partner today.
For additional information, please contact us at:
training@ketamineinstitute.com
Or download the program brochure and fax all required documents to:
850.602.9013
