Not All Ketamine Infusions Are The Same
Learn More About How
We Improved Upon Ketamine
Unlocking the Potential…. Making Ketamine Even More Effective
Not all Ketamine Infusions are the same -
RESTORE is the new "Gold Standard" in ketamine infusion therapy.
Just as we all know that no two people are exactly alike, we also know that they will not each respond to medication in the same way. Because of this, it is important to select the right treatment for the right person to be maximally effective.
Understanding this, we have used it in many different ways over the years to learn more about what it can really do. As a result of our efforts, and after years of clinical use and research, we have developed proprietary ways to increase ketamine's effectiveness and extend the remarkable benefits months to years.
Let’s start with the conventional ketamine infusion. While it can be very helpful for many patients, it has several limitations and draw backs. To begin, the basic ketamine infusion while helpful in mood disorders such as depression or anxiety, is not effective for the treatment of chronic pain. Also it will require at least 6 infusions to begin and then require monthly maintenance infusions after that to sustain any benefit. Most local ketamine clinics, using the conventional 6 infusions over 2-week process, will tell you the single infusion cost, but it is important to remember that you must multiply that number by 6 or more sessions for just the initial treatment. Then, to maintain the benefit, you will need to continue having infusions every 4-6 weeks thereafter. It can become very costly over just the first year – over $8,500.00 in many cases.
The RESTORE Advanced Infusion or the RESTORE Essential-PlusPGx Infusion are actually more effective and a cost less compared to any other ketamine infusion treatment. First, they can be completed in just one long weekend (3 days), so you feel better much faster. Secondly, it lasts much longer than other infusions, you may only need 2 maintenance infusions to maintain the benefits and in many cases - obtain complete relief. Which means that you do not need “monthly boosters” as you do with other infusions. No other ketamine-based infusion can provide the long-lasting benefit of RESTORE. Beyond that, the RESTORE Essential PlusPGx Infusion can be effective when standard ketamine infusions, Spravato or rTMS are not; and the RESTORE Advanced Infusion was is designed for very complex issues and severe chronic pain, something the conventional infusion cannot treat effectively.
How it works:
In basic terms, ketamine blocks a brain receptor known as the NMDA receptor (although it works at many other receptors simultaneously). By blocking specific NMDA receptors, the infusion stimulates a rapid release of the neurotransmitter known as glutamate. Glutamate is an “excitatory” neurotransmitter and this initial but relatively brief “glutamate burst” quickly helps to lessen symptoms of depression and anxiety for the first few days. But then what happens?
Why typical ketamine infusions only provide short term relief –
The good news is that if you are suffering with depression and anxiety, you may have a rapid response. Then, to make the ketamine effect last a little longer than just a few days, up to five or more additional infusions are necessary. Now the bad news; even with 6 or more repeated ketamine infusions the beneficial effects are only temporary, usually lasting 3-4 weeks before you need another infusion. So, while the standard ketamine infusion can be very effective initially, clearly it does not lead to long term relief or remission of symptoms. Still, if nothing has helped you in the past and this does then that is still a great benefit. However, we view this as a “band-aid” type of approach, requiring ongoing monthly infusions to keep feeling better but not providing any long-term benefits. Why doesn’t it last longer?
Why doesn’t it last longer?
There are several reasons why the effects of a ketamine infusion do not last very long. It is important to remember that the original ketamine infusion developed at Yale in 1994, which is now commonly used to treat some mood disorders, was never initially intend to treat depression or anxiety.
All medications we use today come in different dosages – different conditions and different individuals respond best to certain amounts of medication but not others.
However, because of ketamine’s early reported success and the lack of experience of many physicians in using ketamine the original protocol, in which each patient is given 0.5 milligrams of ketamine for each kilogram of overall body weight, was quickly adopted by many without any thought as to the “optimal” or best dosage for that person or condition. After all, early reports suggested it worked better than any conventional medication that way and so it was adopted as “good enough”. But is it?
After years of working with hundreds of patients with difficult to treat conditions, we have identified a number of factors which either contribute to the effects of an infusion or work against them. Often these issues are either not discovered or overlooked by many of those providing ketamine-based therapy. For example, many physicians are unaware of the very important effects and interactions of body mass, common medications and genetic metabolism on the primary and secondary metabolism of ketamine.
Body Composition and Ketamine:
Ketamine is a very “lipophilic” drug which means that it has a natural tendency to quickly and easily accumulate in fatty tissue as opposed to staying in blood stream where it can be delivered to the central nervous system. When ketamine is administered based upon someone’s total body weight and we do not consider body composition (amount of body fat) then under dosing or overdosing is more common than most believe. It goes without saying that this practice can lead to very different responses between individuals.
Another important issue is the interaction between common medications and ketamine. Many are unaware that medications such as Vyvanse, Adderall, Chantix or Lamictal can have a significant impact on how ketamine works. Lamictal, for example, has been reported to completely block the effect of ketamine and we do not advise patients on that medication to have infusions for that reason.
Metabolic and Genetic Issues:
Also, very important to understand the effect of your metabolic profile and genetic makeup on the actions of ketamine. We have found that individuals who have low testosterone or carnitine levels, may not respond optimally and the infusion may not be as effective. That is one reason why we request blood work prior to considering someone for an infusion. If these issues are identified and corrected before the infusion, the beneficial results are greatly improved.
The newest approach to effective treatment is called Precision Medicine. We can use specialized genetic testing when necessary and have found that people with a “BDNF variant” or an “MTHFR variant” can have vastly different responses to ketamine. More than that, this type of testing can show individual differences in each individuals capacity to breakdown medications through what is know as the CYP450 system. Knowing this allows us to provide the best possible dosing strategy to obtain the greatest chance for improvement.
Lastly, and in many ways the most important reason why the benefits of a ketamine infusion are temporary is due to the old protocol used to administer it and dose that is given. These factors together often do not allow for or actually prevent a second, very important step to occur. In order for new brain connections to sprout, grow, connect and finally stabilize, it is necessary that you have a factor to the sustained increase of another vital brain messenger known as “BDNF” or brain derived neurotrophic factor.
How is RESTORE Different?
The RESTORE infusion also exerts its initial effect by stimulating a glutamate burst, rapidly improving symptoms of depression and anxiety but more importantly, it has a secondary, longer lasting mechanism of action. Because of the way in which we formulate, administer and adjust the infusion for each person’s biochemistry and metabolism, RESTORE is able to also significantly increase the production and release of a critical neurochemical known as “brain derived neurotrophic factor” or BDNF. BDNF has been compared to a type of “miracle grow” for brain cells. In the presence of this remarkable growth factor…nerve can begin to repair, reconnect and restore previously damaged connections
It is the extra supply and release of BDNF that promotes long term repair and reconnection of damaged nerve connections that were impaired or lost due to chronic depression and stress. This is the mechanism of long-lasting change that occurs when This is accomplished through the secondary action of metabolites of the infusion which accumulate and act over 5-7 days following the infusion.
Equally important, is the RESTORE supplement® which helps to promote and sustain the nerve regeneration properties of the infusion. The final process involves the “stabilization” of the new connections which continue to occur over time. This process is facilitated by the necessary “maintenance” infusions at 3 months following the first three infusions. The specific intervals for maintenance infusions are important because they prevent the newly established neural connections from fading or disconnecting again leading to the return of previous symptoms of depression and/or anxiety.
By virtue of our unique formulation and 3-day program, RESTORE is able to initiate the revitalization process much faster and produce a durable, long-lasting improvement far beyond any other ketamine infusion. I hope this brief explanation has been helpful.
Now You Know:
So, now you know just a few of the differences between RESTORE and other ketamine infusions. RESTORE is faster acting, longer-lasting, and treats more conditions effectively, while being less expense over time than any other infusion.
That is why RESTORE represents the new "gold standard" in ketamine infusion therapy. We are the only center in the United States that offers the RESTORE Infusions and the Yale-National Institute of Mental Health ketamine infusion, also known as the “standard ketamine infusion".
Now you have choices....
RESTORE is changing the way things are done
The RESTORE Ultra-Rapid Infusion and the RESTORE Essential Infusion are very different from the basic ketamine infusion. We realize that each person is unique, has different needs, experiences and may respond differently to any medication. This must to be taken into account for each person; we know that one size "dose" does not fit everyone.
The RESTORE Infusions are individually tailored to meet your needs and are more effective and can last 3 times longer than other infusions. We have been able to achieve those goals by combining cutting edge research and innovations in the fields of Anesthesiology, Neuropharmacology and Cognition to develop the new RESTORE Infusions.
We understand that living with depression, migraine headache, fibromyalgia or chronic pain can be difficult, but considering a RESTORE Infusion is a step in the right direction. And you’re not alone. RESTORE therapy has been used to treat hundreds of patients all across the country. Learn more about how we can help you today.