Not All Ketamine Infusions Are The Same
Learn More About How
We Improved Upon Ketamine
Unlocking the Potential…. Making Ketamine Even More Effective
Not all Ketamine Infusions are the same -
RESTORE is the new "Gold Standard" in ketamine infusion therapy.
Just as we all know that no two people are exactly alike, we also know that they will not each respond to medication in the same way. Because of this, it is crucial to select the right treatment for the right person to be maximally effective.
Understanding this, we have used it in many different ways over the years to learn more about what it can do. As a result of our efforts, and after years of clinical use and research, we have developed proprietary ways to increase ketamine's effectiveness and extend the remarkable benefits months to years.
Let's start with the conventional ketamine infusion. While it can be beneficial for many patients, it has several limitations and drawbacks. First, the regular ketamine infusion, while helpful in mood disorders such as depression or anxiety, is not practical for treating chronic pain. Also, it will require at least six infusions to begin and then require monthly maintenance infusions after that to sustain any benefit. Most local ketamine clinics, using the conventional six infusions over a 2-week process, will tell you the single infusion cost. Still, it is essential to remember that you must multiply that number by six or more sessions for just the initial treatment. Then, to maintain the benefit, you will need to continue having infusions every 4-6 weeks after that. It can become very costly over just the first year – over $8,500.00 in many cases.
The RESTORE Advanced Infusion or the RESTORE Essential Infusion is more effective and costs less than ketamine infusion treatment. First, they can be completed in just one long weekend (3 days), so you feel better much faster. Secondly, it lasts much longer than other infusions. This means that you do not need "monthly boosters" as you do with other ketamine infusions. You may only need two maintenance infusions to maintain the benefits and, in many cases - obtain complete relief. No other ketamine-based infusion can provide the long-lasting advantage of RESTORE. Beyond that, the RESTORE Essential Infusion can be effective when standard ketamine infusions, Spravato, or rTMS are not. The RESTORE Advanced Infusion was designed for very complex issues and severe chronic pain, something the conventional infusion cannot treat effectively.
Compare RESTORE to Regular Ketamine - Side by Side
How it works:
But then what happens? In basic terms, ketamine blocks a brain receptor known as the NMDA receptor (although it works at many other receptors simultaneously). By blocking specific NMDA receptors, the infusion stimulates a rapid release of the neurotransmitter known as glutamate. Glutamate is an "excitatory" neurotransmitter, and this initial but relatively brief "glutamate burst" quickly helps to lessen symptoms of depression and anxiety for the first few days.
Why typical ketamine infusions only provide short term relief –
The good news is that if you are suffering from depression and anxiety, you may have a rapid response. Then, to make the ketamine effect last a little longer than just a few days, up to five or more additional infusions are necessary. Now the bad news; even with six or more repeated ketamine infusions, the beneficial effects are only temporary, usually lasting 3-4 weeks before you need another infusion. So, while the standard ketamine infusion can be very effective initially, clearly, it does not lead to long-term relief or remission of symptoms. Still, if nothing has helped you in the past and this does, then that is still a great benefit. However, we view this as a "band-aid" approach requiring ongoing monthly infusions to keep feeling better but not providing any long-term benefits. Why doesn't it last longer?
Why doesn't regular ketamine last longer?
There are several reasons why the effects of a ketamine infusion do not last very long. It is important to remember that the original ketamine infusion developed at Yale in 1994, which is now commonly used to treat some mood disorders, was never initially intended to treat depression or anxiety.
All medications we use today come in different dosages – different conditions and different individuals respond best to specific amounts of medicine but not others.
Due to ketamine's early reports of success, the original protocol, in which each patient receives 0.5 milligrams of ketamine for each kilogram of overall body weight, was quickly adopted by many without any thought as to the "optimal" or best dosage for that person or condition. After all, early reports suggested it worked better than any conventional medication that way, and so it was adopted as "good enough." But is it?
After years of working with hundreds of patients with difficult to treat conditions, we have identified many factors that either contribute to an infusion's effects or work against them. Often these issues are either not discovered or overlooked by many of those providing ketamine-based therapy. For example, many physicians are unaware of the significant effects and interactions of body mass, common medications, and genetic metabolism on the primary and secondary metabolism of ketamine.
Body composition and ketamine:
Ketamine is a very "lipophilic" drug. It has a natural tendency to quickly and easily accumulate in fatty tissue instead of staying in the bloodstream, delivered to the central nervous system. When ketamine is administered based on someone's total body weight and does not consider body composition (amount of body fat), underdosing or overdosing is more common than most believe. This practice can lead to very different responses between individuals.
Other medications affect how ketamine works:
Another critical issue is the interaction between common medications and ketamine. Many are unaware that drugs such as Vyvanse, Adderall, Chantix, or Lamictal can significantly impact how ketamine works. Lamictal, for example, has been reported to block the effect of ketamine entirely, and we do not advise patients on that medication to have infusions for that reason.
Metabolic and Genetic issues can alter ketamine processing:
Also, very important to understand the effect of your metabolic profile and genetic makeup on the actions of ketamine. We have found that individuals with low testosterone or carnitine levels may not respond optimally, and the infusion may not be as effective. That is one reason why we request blood work before considering someone for an infusion. If these issues are identified and corrected before the infusion, the beneficial results are greatly improved.
The newest approach to effective treatment is called Precision Medicine. We can use specialized genetic testing when necessary and have found that people with a "BDNF variant" or an "MTHFR variant" can have vastly different responses to ketamine. More than that, this type of testing can show individual differences in each individual's capacity to break down medications through what is known as the CYP450 system. Knowing this allows us to provide the best possible dosing strategy to obtain the most excellent chance for improvement.
Older Protocol = lower levels of effectiveness:
Lastly, and in many ways, the most crucial reason why the benefits of a ketamine infusion are temporary is due to the old protocol used to administer it and the dose. These factors together often do not allow for or prevent a second, significant step from occurring. For new brain connections to sprout, grow, connect and finally stabilize, you must have a factor to the sustained increase of another vital brain messenger known as "BDNF" or brain-derived neurotrophic factor.
How is RESTORE Different?
The RESTORE infusion also exerts its initial effect by stimulating a glutamate burst, rapidly improving symptoms of depression and anxiety. More importantly, it has a secondary, longer-lasting mechanism of action. We formulate, administer and adjust the infusion for each person's biochemistry and metabolism. Because we tailor the treatment, RESTORE significantly increases the production and release of a critical neurochemical known as "brain-derived neurotrophic factor" or BDNF. BDNF has been compared to a type of "miracle grow" for brain cells. In the presence of this remarkable growth factor — nerves can begin to repair, reconnect and restore previously damaged connections.
The extra supply and release of BDNF promote long-term repair and reconnection of damaged nerve connections that were impaired or lost due to chronic depression and stress. The release of BDNF is accomplished by metabolites that accumulate and continue to act over 5-7 days following the infusion.
The final process involves the "stabilization" of the new connections, which continue to occur over time. The necessary "maintenance" infusions facilitate this process at three months following the first three infusions. The specific intervals for maintenance infusions are vital because they prevent the newly established neural connections from fading or disconnecting again, leading to the return of previous symptoms of depression and anxiety.
Equally important is the RESTORE supplement®, which helps promote and sustain the nerve regeneration properties of the infusion.
Now You Know:
So, now you know just a few of the differences between RESTORE and other ketamine infusions. RESTORE is faster acting, longer-lasting, and treats more conditions effectively while being less expensive over time than any other ketamine infusion.
That is why RESTORE represents the new "gold standard" in ketamine infusion therapy. We are the only center in the United States that offers the RESTORE Infusions and the Yale-National Institute of Mental Health ketamine infusion, also known as the "standard ketamine infusion."
Now you have choices.
RESTORE is changing the way things are done
The RESTORE Ultra-Rapid Infusion and the RESTORE Essential Infusion are very different from the basic ketamine infusion. We realize that each person is unique, has different needs, experiences and may respond differently to any medication. This must to be taken into account for each person; we know that one size "dose" does not fit everyone.
The RESTORE Infusions are individually tailored to meet your needs and are more effective and can last 3 times longer than other infusions. We have been able to achieve those goals by combining cutting edge research and innovations in the fields of Anesthesiology, Neuropharmacology and Cognition to develop the new RESTORE Infusions.
We understand that living with depression, migraine headache, fibromyalgia or chronic pain can be difficult, but considering a RESTORE Infusion is a step in the right direction. And you’re not alone. RESTORE therapy has been used to treat hundreds of patients all across the country. Learn more about how we can help you today.