Ketamine Research Institute
The "Mini-Fellowship" Intensive Ketamine Training Program for Clinicians
Meeting All:
American Psychiatric Association | American Society of Anesthesiologists Recommendations for Didactic and Supervised Clinical Training
Master What Others Can’t Offer
Why KRI Training Delivers Superior Patient Outcomes
Clinicians trained through KRI's Mini-Fellowship achieve 70-75% success rates—matching research institutions—while standard community clinics see only 20-50% response rates. The difference isn't the medication; it's the methodology. While most programs still teach the outdated 0.5mg/kg "one-size-fits-all" protocol that leads to 50% treatment failures and 47% patient dropout rate, KRI graduates master:
• Precision dosing through pharmacokinetic modeling that eliminates the guesswork, causing most failures
• Genetic-based protocols (CYP450, MTHFR, BDNF variants) that identify ultra-rapid metabolizers and predict response patterns
• Metabolic optimization techniques that address the physiological barriers sabotaging 60-70% of "non-responders" elsewhere
• Advanced adverse effect management that dramatically reduces dropout rates and improves treatment tolerance
The outcome: fewer complications, higher patient compliance, better safety profiles, and the consistent results that build thriving referral-based practices. As the only U.S. program fully meeting APA and ASA standards—combining supervised clinical experience, personal ketamine immersion, and year-long mentorship—KRI training ensures you deliver the precision medicine approach that research institutions use, but 95% of ketamine providers never learn. When studies show up to 8% of patients worsen under inadequately trained providers, anything less is a disservice to patients who deserve expert-level care.
Transforming Lives with Ketamine Therapy
The KRI Mini-Fellowship: Beyond Certification—Toward Clinical Mastery
A Program Designed for Clinicians Who Want to Do It Right
Are Your Patients Getting the Results They Deserve?
If you’re new to ketamine therapy—or if you’ve already launched a ketamine treatment center that isn’t delivering the outcomes you expected—you’re facing a critical gap that most clinicians don’t even realize exists.
Here’s the uncomfortable truth: While research studies report 70-75% success rates with ketamine therapy, community-based clinics see results as low as 20-50%. Patients drop out. Side effects aren’t appropriately managed. And the “breakthrough treatment” you invested in becomes just another underperforming protocol.
The difference isn’t the medication—it’s the methodology.
This is where the Ketamine Research Institute's Mini-Fellowship makes a significant difference. Our advanced training goes beyond the outdated “one-size-fits-all” approach that’s failing patients across the country. You’ll master the Personalized Medicine and Targeted Infusion Therapy techniques that research institutions use to achieve those remarkable 70-75% success rates—but that almost no one is teaching community practitioners.
This is where everything changes.
The Ketamine Research Institute’s Mini-Fellowship teaches you the Personalized Medicine and Targeted Infusion Therapy techniques that research institutions use to achieve those remarkable success rates—but that almost no one is teaching community practitioners. With 35+ years of clinical experience and research, supervised hands-on training, and advanced pharmacokinetic expertise that exceeds all APA and ASA recommendations, you’ll finally master the precision and safety protocols that separate true ketamine experts from the growing crowd of “ketamine clinics.”
You don’t just treat symptoms—you transform lives.
We train clinicians who refuse to accept “treatment resistant as the final answer. The KRI Mini-Fellowship Intensive Ketamine Training Program isn’t just a 3-Day certification course—it’s a comprehensive, year-long mentorship and consulting experience designed to position you as a true expert in ketamine therapy, and it is the only program in the U.S. that fully meets the American Psychiatric Association and American Society of Anesthesiology guidelines for ketamine training.
Master What Others Can’t Offer
Most clinicians who are interested in adding ketamine infusion therapy to their practice face the same challenges: uncertainty about how to get started, lack of trustworthy guidance, and the fear of becoming “just another clinic” in a crowded space. Our program was built to solve these problems for you—step by step.
Choosing the Right Training Program Can Be Confusing.
The Training Decision That Determines Your Success—Or Your Patients' Safety
The Training Decision That Determines Your Success—Or Your Patients' SafetyAdding ketamine therapy to your practice isn’t just a procedural shift—it’s a clinical, ethical, and strategic decision that demands more than an online or weekend introductory ketamine course. The KRI Mini-Fellowship is the only ketamine training program in the U.S. that fully meets the American Psychiatric Association and American Society of Anesthesiology standards, and it’s built to do one thing: ensure you're prepared to deliver safe, effective, and outcome-driven ketamine care from day one.
Only a 40% Success Rate: Is "Basic Training" Good Enough for Your Patients?
The Problem With "One-Size-Fits-All" Ketamine Protocols
Many programs teach the basics. Few prepare you for real-world complexity. Most rely on outdated, standardized dosing protocols that lead to suboptimal outcomes—where fewer than 40% of patients improve, and up to 8% worsen. Is that what you want for your patients?
Beyond the Certificate: What Real Ketamine Competence Actually Requires
Getting "Certified" Is the Easy Part. Here's What Actually Matters.
Most ketamine training programs focus on certification—watch the videos, complete the modules, get your credentials. That's a starting point.
But clinical competence begins where certification ends. When your first complex patient arrives—treatment-resistant depression, multiple medication interactions, CYP450 variants, atypical metabolism—you need more than protocols. You need to understand why one patient responds at 0.5mg/kg while another requires 1.2mg/kg.
Real competence means confidently adjusting infusion rates based on physiological parameters and dissociative intensity, recognizing early warning signs, and managing 50% of cases that don't fit standard protocols. It's understanding the advanced pharmacology that transforms ketamine from a drug you administer into a therapeutic tool you master.
The difference shows in the confidence you feel on Monday morning and the outcomes your patients experience on Tuesday afternoon.
When the Infusion Goes Wrong, Your Videos Won't Answer the Phone
The Moment You Realize Your Training Didn't Cover This
When their blood pressure spikes during the infusion, when they experience severe dissociation, when your "standard protocol" isn't working, you're alone with no real preparation for the clinical emergencies you're facing. Pre-recorded videos can't answer your urgent questions. PowerPoint slides don't teach you how to handle real-time complications. Virtual case studies don't replicate the reality of a dissociating, hypertensive patient asking to stop treatment.
If It's Serious Enough to Transform Lives, It's Serious Enough to Train Properly
Welcome to the KRI Intensive Mini-Fellowship Program
Ketamine therapy isn't a simple procedure—it's a sophisticated psychiatric intervention using a controlled substance with complex pharmacology, significant adverse effect potential, and profound psychological impact. Would you learn to perform surgery from online videos? Would you trust a cardiologist who learned interventional procedures from weekend webinars?
We teach a different approach: individualized, precision-based care informed by pharmacokinetics, metabolism, comorbidities, and real-time clinical observation.
The KRI Mini-Fellowship: Beyond Certification—Toward Clinical Mastery
A Program Designed for Clinicians Who Want to Do It Right
What You Gain from Our Training — Clinically and Professionally
➤ Mastery Through Clinical Experience
We immerse you for three intensive days in our operational ketamine infusion center, where you perform—not just observe. Under expert supervision, you'll administer actual infusions to real patients, calculate personalized doses using pharmacokinetic modeling, respond to live complications, and master emergency protocols with immediate feedback.
You'll also experience a ketamine infusion yourself, gaining irreplaceable firsthand insight into the patient journey that transforms how you select candidates and optimize outcomes. This isn't a simulation—it's real clinical practice where you develop genuine competence and confidence before treating your first patient alone.
➤ Master Advanced Techniques That 95% of Ketamine Providers Never Learn
While most ketamine clinics still use the outdated and imprecise 0.5 mg/kg protocol developed in 1994—producing wildly unpredictable results where 30-50% of patients fail to respond—you'll master the precision medicine techniques that research institutions use to achieve 70-75% success rates. Learn to administer target-controlled infusions using pharmacokinetic modeling to calculate precise doses that achieve specific plasma concentrations for each diagnosis. This isn't guessing—it's pharmaceutical precision that eliminates the dosing variability causing most treatment failures.
You'll integrate genetic testing results (Genomind interpretation) to identify CYP450 ultra-rapid metabolizers who require dose increases, MTHFR variants that necessitate pre-treatment methylfolate supplementation, and BDNF polymorphisms that predict response patterns.
Master lab-guided metabolic optimization protocols addressing metabolic and hormonal issues such as testosterone deficiency, magnesium depletion, thyroid dysfunction, and carnitine deficiency—correcting the physiological barriers that sabotage 60-70% of "non-responders" at other clinics.
Go beyond the outdated 0.5 mg/kg model. Learn target-determined infusions, genetic and lab-guided adjustments, and strategies to mitigate adverse effects—enabling you to deliver better outcomes and consistently gain more referrals.
➤ The Missing Element in Every Other Ketamine Infusion Training Program
The Ketamine Experience
Every other ketamine training teaches you what ketamine does to patients—we show you what ketamine feels like to patients. There's a profound difference between intellectual understanding ("patients may experience dissociation and altered time perception") and embodied knowledge ("this is the exact moment when patients feel they're losing control and need reassurance"). You'll undergo a supervised ketamine infusion yourself, experiencing the complete patient journey: the anticipation and anxiety before administration, the unsettling dissolution of normal perception as effects begin, the profound dissociation at therapeutic plasma levels, the emotional insights that can be either revelatory or disturbing, and the gradual return to baseline consciousness. This firsthand experience is clinically transformative in ways that even experienced psychiatrists find surprising.
Patient selection becomes intuitive—you'll recognize during consultations which personalities will navigate the experience successfully versus those who'll panic and discontinue. Informed consent becomes genuine—you're not reading side effects from a form, you're describing real sensations you've personally felt, building immediate trust and credibility.
Expectation management becomes accurate—you prepare patients for the actual psychological journey, not textbook descriptions, dramatically reducing anxiety-driven dropout. Real-time clinical guidance becomes expert—you know exactly when patients need verbal reassurance, when silence is more effective, when intensity is therapeutic rather than overwhelming, and when dose adjustments are necessary.
Your therapeutic presence becomes authentic—patients sense the difference between a provider who's read about ketamine and one who truly understands their experience. This experiential knowledge is the secret advantage that creates superior outcomes, stronger patient relationships, and the enthusiastic testimonials that build thriving practices. No amount of reading or video watching can replicate this—it must be experienced to be understood.
➤ Twelve Months of Expert Support: Because Mastery Doesn't End in Three Days
Our One-Year Clinical Mentoring Program
The difference between our program and others isn't just the superior training—it's what happens after you leave. For an entire year, you will have direct access to our clinical team for case consultations, protocol troubleshooting, dose optimization guidance, and emergency support whenever complex situations arise. Whether you're interpreting genetic testing results, managing an unexpected adverse reaction, navigating insurance pre-authorization, selecting equipment vendors, or developing marketing strategies, you're never alone trying to Google answers at midnight.
This ongoing mentorship transforms isolated practitioners into members of an elite professional network, achieving 70%+ success rates—not through luck, but through continuous expert guidance that ensures every one of your patients benefits from our collective 35+ years of experience. Other programs certify you and disappear; we invest in your long-term success because your outcomes are our legacy.
➤ Complete Clinical Implementation System—Not Just Templates
Your Turn-Key Practice Solution
You receive our complete, experience-tested operational system: the proprietary KRI Clinical Companion app with real-time pharmacokinetic dosing calculators, genetic test interpretation guides, and drug interaction algorithms; medico-legally vetted documentation (evaluation templates, DEA-compliant logbooks, informed consent forms, procedural notes, emergency protocols); the Ketamine Evaluation and Optimization Guide with patient-specific dose adjustment tables for MTHFR variants, CYP450 metabolism, and medication interactions; plus comprehensive safety protocols exceeding ASA/APA standards. These aren't PDFs you'll modify—they're proven systems you implement immediately, protecting you legally while delivering precision medicine from your first patient.
➤ Why Most Ketamine Practices Fail—And How Ours Guarantees Your Success
The Training That Ensures Your Practice Not Only Succeeds—It Thrives.
The uncomfortable truth: Most new ketamine practices underperform or fail within the first year, usually from a combination of poor clinical skills, but also from business mistakes that destroy profitability and reputation. The "certification" they received taught them nothing about actually running a successful practice.
We eliminate every failure point with our tested systems, including vetted equipment suppliers with negotiated pricing, pharmaceutical vendor relationships that prevent supply interruptions, and per-treatment cost breakdowns that eliminate financial surprises. You'll implement proven staff training protocols to avoid costly errors, workflow systems that maximize daily capacity, and quality frameworks that open hospital privileging and insurance opportunities competitors can't access.
Every system connects to a year-long mentorship—immediate expert guidance when challenges arise, rather than relying on expensive consultants or painful trial-and-error processes that can cost months of revenue. You're not launching another "ketamine service"—you're building a premium practice with sustainable competitive advantages. While competitors struggle, discount services achieve only a 40% success rate, generating negative word of mouth. You'll operate efficiently, maintain premium positioning, deliver outcomes of 70% or more, create referral momentum, and dominate your market. Your business infrastructure doesn't just support clinical excellence—it amplifies it into unstoppable practice growth.
➤ Professional Recognition That Opens Doors and Builds Your Reputation
Build the Reputation You Deserve—and the Recognition That Follows
Upon graduation, you receive far more than a certificate—you gain professional credentials that immediately distinguish you in a crowded marketplace. Your KRI certification signals to referring physicians, hospital credentialing committees, and malpractice insurers that you've completed the most rigorous ketamine training in America, meeting or exceeding all APA and ASA standards. Automatic inclusion in our national KRI Clinician Directory positions you in front of thousands of prospective patients actively searching for expertly trained ketamine providers—generating qualified leads without marketing expense. Perhaps most valuable, you join an exclusive network of elite practitioners committed to precision medicine and clinical excellence, providing ongoing peer consultation, complex case discussions, and collaborative problem-solving that continue to advance your expertise long after formal training ends.
When patients research ketamine providers, your KRI credentials immediately establish authority—you're not "another ketamine clinic," you're a fellowship-trained specialist using advanced protocols. When psychiatrists evaluate referral options, your directory listing and proven training convince them to trust you with their most challenging patients. When hospitals review privileging applications or insurance companies assess provider qualifications, your KRI certification demonstrates the comprehensive preparation that generic "weekend course" certificates cannot.
You're not just offering ketamine therapy—you're offering fellowship-level expertise, backed by demonstrable training, proven protocols, and a professional network that ensures continuous excellence. That distinction is the competitive moat protecting premium practices from commodity competition.
Your Next Patient's Breakthrough Begins With Your Decision Today
Transform Lives with Confidence—Not Guesswork
Don't let another patient leave feeling hopeless when you can offer a genuine transformation. Join forward-thinking clinicians who are redefining what's possible in mental healthcare. And build the practice you've always envisioned, where your expertise creates life-changing results and hope.
Deliver Transformation from Day One.
Apply Now for the Mini-Fellowship
The Ketamine Research Institute Mini-Fellowship: Where Precision Medicine Meets Clinical Excellence
The Premier Ketamine Therapy Training Course for Clinicians
Transform Your Practice with the Only Training Program That Teaches Beyond Outdated Protocols
If you’re an MD, DO, NP, or CRNA seeking to revolutionize your practice and establish yourself as an expert in ketamine therapy, look no further. The Ketamine Research Institute’s "Mini-Fellowship" Intensive Training Program is not just another ketamine course—it’s the definitive pathway to clinical excellence, patient satisfaction, and professional recognition in this rapidly evolving field. The Mini-Fellowship Intensive is the most advanced and comprehensive ketamine training available—designed for clinicians serious about mastering precision-based, high-impact therapy.
Unlike online-only courses, this program provides a comprehensive blend of didactic instruction, immersive hands-on clinical experience, and personalized mentoring. Clinicians are trained using a cutting-edge approach to Personalized Medicine and Targeted Infusion Therapy, learning not only the fundamentals but also advanced pharmacokinetic modeling, precision dosing, and patient-tailored protocols. This ensures you can deliver safer, more effective, and better-tolerated treatments, setting your practice apart from typical "one-size-fits-all" protocols.
Our Invaluable Tools for Success in Ketamine Therapy include:
The Complete Clinical Reference Manual of Ketamine: From Theory to Practice
The Ketamine Research Institute training manual represents a comprehensive compendium of advanced ketamine knowledge, authored by Dr. Gerald W. Grass, MD, Medical Director of KRI. The manual serves as an invaluable reference source, consolidating cutting-edge research, pharmacokinetic principles, and a mechanistic understanding of ketamine's complex therapeutic actions across multiple clinical applications.
The manual serves as both an educational resource and a detailed pharmacological reference, covering advanced topics such as NMDA receptor antagonism, mechanisms of neuroplasticity, and ketamine's metabolite pathways. It contains an in-depth analysis of dosing pharmacokinetics, drug interactions, contraindications, and the intricate relationship between ketamine's dissociative and antidepressant properties.
Your Personal Desk Reference Guide
Your Personal Desk Reference GuideFor clinicians working with ketamine therapy, this manual serves as a critical desk reference for understanding the sophisticated pharmacological principles underlying this versatile therapeutic agent, making it an essential resource for evidence-based clinical decision-making.
New for the 2026 Training Program:
Ketamine Research Institute Clinical Companion App
The KRI Clinical Companion: Your Essential Tool for Treatment Excellence
The KRI Clinical Companion is the first and only comprehensive mobile application specifically engineered to optimize ketamine therapy outcomes through precision medicine protocols. This proprietary decision-support system addresses the critical gap between basic ketamine administration and the advanced clinical precision required to achieve consistent, superior patient outcomes.
Why This Changes Everything for Your Practice
Most ketamine treatment failures aren't due to the medication—they stem from overlooked patient-specific variables that standard protocols ignore. The KRI Clinical Companion eliminates this guesswork by providing real-time, evidence-based clinical guidance for every patient, every session.
Unique Clinical Capabilities
Unique Clinical Capabilities➤ Genetic-Based Precision Dosing: Automatically calculates optimal plasma concentrations based on CYP450 genetic variants and patient-specific metabolic factors, ensuring therapeutic levels while minimizing adverse effects. The system accounts for how your patient's unique genetic profile affects ketamine metabolism, absorption, and clearance—transforming generic dosing into personalized pharmacotherapy that no other ketamine resource can provide.
➤ Real-Time Plasma Concentration Monitoring: Dynamic plasma concentration curves display exactly where your patient is in the ketamine experience at any given moment during the infusion. This visual tracking system shows the rise, peak, plateau, and decline phases in real-time, allowing you to predict and respond to the patient's neurophysiological state with precision. You'll know when they're entering peak dissociative states, when therapeutic levels are optimized, and when to adjust rates to maintain the ideal treatment window—eliminating guesswork and ensuring consistent therapeutic response.
➤ Comprehensive Pre-Treatment Assessment and Optimization: Full metabolic and genetic evaluation system identifies critical factors that dramatically influence treatment response. The app screens for MTHFR variants, BDNF polymorphisms, testosterone levels, magnesium status, carnitine deficiency, thyroid function, and other biomarkers that predict treatment success. Rather than discovering these issues after treatment failure, you'll identify and address them upfront—dramatically improving your first-session response rates and overall treatment outcomes.
➤ Intelligent Drug Interaction Analysis: Instant evaluation of all patient medications for ketamine-specific interactions, contraindications, and synergistic effects. The system analyzes pharmacokinetic interactions, alerts you to drugs that may enhance or inhibit ketamine metabolism, and flags potentially dangerous combinations. This comprehensive safety screening protects both your patients and your practice with every case.
➤ Personalized Protocol Optimization Engine: Dynamic treatment recommendations continuously evolve based on your patient's diagnosis, genetic profile, metabolic status, comorbidities, and session-by-session response patterns. The app learns from each treatment, suggesting protocol modifications to maximize efficacy—whether that's adjusting infusion rates, modifying total dosing, recommending pre-treatment supplementation, or tailoring session frequency. This is precision medicine in action, not generic one-size-fits-all protocols.
➤ Comprehensive Clinical Documentation System: Integrated clinical notes section allows you to record detailed patient experiences, subjective reports, physiological responses, and treatment observations in real-time during each session. Document dissociative experiences, emotional processing, adverse reactions, insights reported by patients, and treatment tolerability. This longitudinal tracking creates a complete clinical narrative for each patient, enabling you to identify response patterns, refine protocols, and maintain thorough records for continuity of care. The documentation system also facilitates outcome tracking across multiple sessions, helping you demonstrate treatment efficacy and justify continued care.
The Clinical Impact
This isn't just an app—it's the clinical intelligence system that enables you to achieve the 70-75% success rates documented in research settings, rather than the 20-50% outcomes common in practices using standard approaches. Every feature translates directly to improved patient safety, faster response times, and superior treatment durability.
Access Anywhere, Anytime
Secure, mobile-friendly interface provides on-screen clinical recommendations during sessions, ensuring you have expert-level decision support for medication modifications when it matters most.
The KRI Clinical Companion represents years of advanced ketamine pharmacology distilled into immediate, actionable clinical guidance. It's the difference between basic certification knowledge and true clinical mastery—and your patients will experience that difference from their very first session.
Nothing Else Comes Close
No other resource in the ketamine space offers this level of integrated clinical intelligence. While other providers rely on static protocols and generic dosing guidelines, you'll have access to dynamic, patient-specific guidance that evolves with each treatment session. This is the difference between practicing ketamine therapy and mastering it.
The KRI Clinical Companion represents years of advanced ketamine pharmacology, genetic research, and clinical experience distilled into immediate, actionable guidance. It's the difference between basic certification knowledge and true clinical mastery—and your patients will experience that difference from their very first session.
The Complete Business Blueprint for Seamless Integration
Imagine walking into your practice Monday morning after training, knowing exactly what to do next—no uncertainty, no overwhelm, no expensive trial-and-error. That's what our turn-key business implementation system delivers. We've anticipated every question and solved every challenge you'll face: our detailed space planning shows precisely how to set up safe, efficient infusion areas within your existing facility.
You'll know your profitability before treating your first patient, staff exactly what they'll do, and implement operational systems preventing the chaos that derails most new clinical services.
Everything You Need for Smooth Operations and Perfect Compliance
Clinical excellence requires operational excellence, characterized by smooth workflows, proper documentation, and flawless regulatory compliance. You'll implement our complete documentation system:
➤ Complete Medical Documentation: evaluation templates, informed consents, procedural notes, infusion records—all formatted to professional standards.
➤ A comprehensive DEA-controlled substance management program: handling procedures, security requirements, a complete logbook system, disposal documentation, staff training, and preventing violations.
➤ Optimized patient scheduling protocols: maximizing daily capacity without compromising care quality.
➤ Detailed emergency response procedures: equipment, medications, staff roles, documentation, and
➤ Continuous quality monitoring systems: outcome tracking, safety metrics, improvement processes.
Our business model comparison guides help you choose the optimal structure, whether independent, integrated, hospital-affiliated, or concierge, and provide implementation roadmaps for each option. Most importantly, every system integrates with a year-long mentorship providing immediate expert guidance when questions arise during implementation.
You're not alone wondering, "Is this right?" or "What do I do now?" You're implementing with confidence because every step is mapped out, every question is answered, and expert support is immediately available. While other "certified" providers struggle for months figuring out basic operations, you'll launch smoothly within 4-6 weeks and operate efficiently from day one, focusing on patient care rather than operational chaos. This is how serious training prepares you for real success.
Ketamine PLUS: The Clinician’s Marketing Handbook
Establishing Professional Excellence and Recognition in Ketamine Therapy.
This comprehensive marketing strategy manual empowers KRI fellowship-trained clinicians to establish themselves as recognized experts in advanced ketamine therapy while ensuring the highest standards of patient care and professional practice. By implementing the evidence-based communication strategies outlined in this guide, you will effectively differentiate your personalized medicine approach from standard protocols, helping patients and referring physicians understand the superior safety profile and clinical outcomes enabled by pharmacokinetic modeling, individualized dosing, and continuous monitoring.
The manual provides ethical frameworks for communicating your advanced training credentials, clinical expertise, and commitment to exceeding APA and ASA recommendations, positioning you as the preferred provider for treatment-resistant patients who require sophisticated medical intervention beyond conventional approaches.
Be Recognized as a Ketamine Expert and Leader in the Field
The systematic implementation of these professional marketing principles directly supports improved patient outcomes by ensuring that individuals requiring advanced ketamine protocols can identify and access your specialized services. Through targeted educational content, professional networking strategies, and evidence-based messaging, you will build a referral network of healthcare providers who understand when to recommend personalized ketamine therapy over standard treatments, ultimately improving treatment success rates and patient safety in your community.
This approach not only establishes your reputation as a clinical expert committed to the highest standards of care but also ensures that your practice operates in full compliance with professional guidelines while serving patients who have exhausted traditional treatment options and require the sophisticated, individualized protocols that only KRI-trained specialists can provide.
Complete Implementation Package: A 110-page strategy manual featuring evidence-based frameworks, professional communication templates, and systematic approaches for establishing clinical expertise while upholding the highest standards of patient care and professional compliance.
Leading the Future of Precision Ketamine Therapy
Our program and approach are more than training—it’s a transformation.
Our program offers an unmatched clinical education that distinguishes you as a leader in ketamine therapy. Become the go-to expert in ketamine therapy, trusted by peers and sought out by discerning patients.
The Ketamine Research Institute Mini-Fellowship Training Program offers rigorous clinical knowledge, practical skills, and access to a global network of respected professionals. Gain the confidence and credentials to speak at conferences, publish, and mentor others in this rapidly growing specialty. Position yourself as a trusted authority, ready to lead colleagues and patients alike into the new era of medical therapeutics.
Ready to advance your career, expand your impact, and lead in the field of transformative medicine? Join us in the only program that combines personal ketamine experience, hands-on clinical training, and advanced precision-medicine techniques into one comprehensive package.
Join with Us and Our New Graduates
Apply Now for the Mini-FellowshipYour Success with Ketamine Therapy Hinges on Choosing the Right Training Program
Better Training. Better Outcomes. Your Success Depends on It.
The increasing popularity of ketamine therapy has led to a proliferation of training programs. However, the quality of these offerings varies widely, leaving clinicians—particularly those new to ketamine—struggling to identify programs that provide the depth and rigor needed to ensure safe, effective treatment. Many programs lack a unified, evidence-based curriculum and instead rely on multiple instructors with varying levels of expertise. This fragmented approach can yield subpar outcomes for both clinicians and patients.
Many Training Programs Rely on Old Ketamine Techniques: Here’s Why You’re Setting Your Patients Up for Failure"
Many existing ketamine training programs continue to teach outdated, standard infusion protocols, including the conventional 0.5 mg/kg dosing recommendations, which were never subjected to large-scale clinical testing. These protocols often rely on a "one-size-fits-all approach", resulting in imprecise, unreliable dosing that frequently leads to under- or overdosing in real-world patients.
The One-Size-Fits-All 0.5mg/kg Myth: It Doesn't Work Well for Many Patients.
Your Ketamine Protocol May Be Causing Treatment Failures—And You Don't Even Know It
Clinicians who use the 0.5mg/kg - "one-size-fits-all" protocol find that many of their patients either don't improve or experience intolerable side effects.
This is because many factors can affect ketamine blood levels that are not accounted for. When this happens, many patients experience plasma levels that are either too low to produce improvement or too high, thereby increasing the risk of adverse effects. As research studies continue to show, such outdated approaches lead to poor and inconsistent treatment outcomes, with many patients experiencing minimal benefit or discontinuing treatment altogether.
Clinicians trained in outdated protocols may unknowingly perpetuate suboptimal outcomes, leaving both themselves and their patients at a distinct disadvantage in a rapidly evolving field of precision medicine. By choosing programs that still adhere to these imprecise guidelines, clinicians risk not only compromising their practice but also providing substandard care that falls behind the latest advances in ketamine therapy.
Outdated Ketamine Protocols = Disappointing Results: Are You Setting Your Patients Up for Failure?
Outdated Protocols Create Poor Outcomes. Precision Medicine Creates Success
While high-quality research studies report impressive results for ketamine therapy, real-world outcomes often fall alarmingly short. Studies show that fewer than 50% of patients experience significant symptom improvement when treated in community-based settings, and up to 8% may experience worsening symptoms (McInnes et al., 2022; Sakurai et al., 2020; Wilkinson et al., 2018).
In addition, many patients fail to complete the induction series or discontinue treatment prematurely, with up to 47% dropping out due to adverse effects or insufficient improvement (Kumar, P.S. et al., 2024). Worrisome, too, are reports that some patients may not only experience a worsening of their symptoms but also report becoming suicidal after treatment (McInnes et al., 2022), further emphasizing the need for rigorous, evidence-based training to minimize these risks.
These discrepancies are often due to inadequate clinician training, inconsistent protocols, and insufficient patient preparation or follow-up care. Such shortcomings not only undermine the potential of ketamine therapy but can also harm its reputation as a transformative treatment.
What Clinicians Should Demand in Training
Clinicians seeking to offer ketamine therapy must prioritize training programs that adhere to the American Psychiatric Association (APA) and American Society of Anesthesiologists (ASA) recommendations for comprehensive education. More than that, training programs should advance the knowledge base of ketamine therapy, including:
Didactic Education: Evidence-based and experience-proven detailed instruction on ketamine’s complex pharmacology, mechanisms of action, drug-drug interactions, indications, and risks.
Advanced infusion protocols: based on individualized dosing and precision medicine to ensure optimal therapeutic outcomes.
Enhanced Patient Evaluation: Enhanced patient evaluation and optimization guides, including genetics, comorbidities, and medication interactions to maximize safety and efficacy.
Supervised Clinical Training: Real-world experience administering ketamine under close supervision to build confidence and skill.
Individualized Mentorship: Although not explicitly required, the benefit of ongoing guidance from experienced professionals to refine clinical practices and address complex cases is invaluable.
Hands-On Training: Research also highlights the importance of hands-on training in equipping clinicians with the skills to deliver consistent, high-quality outcomes (Sanacora et al., 2017). Without these elements, clinicians risk perpetuating common pitfalls observed in many community practices, such as improper dosing, failure to manage adverse effects, suboptimal patient preparation, and subpar treatment outcomes.
Ketamine Research Institute Mini-Fellowship - Setting a New Standard of Care
From Training to Transformation: The Small-Group Intensive That Delivers Real Patient Results
Our immersive 3-day intensive combines small-group, personalized tutorials with practical application, ensuring you gain skills that lead directly to exceptional patient outcomes. With exclusive insights and techniques other programs overlook, the Mini-Fellowship empowers you to rise above the standard and achieve clinical success.
More Than That...This program offers exclusive features not found anywhere else, including:
The Rapid Guide to Ketamine Therapy
Enhanced Patient Selection Protocol - Master our proprietary screening methodology that goes beyond basic contraindications to identify ideal candidates, dramatically improving success rates and reducing adverse outcomes
Pre-Infusion Evaluation and Optimization Program - Learn our systematic patient preparation protocols that optimize treatment readiness through targeted interventions, ensuring maximum therapeutic benefit from each session
Precision Medicine Protocols - Master genetic-based dosing strategies incorporating MTHFR, BDNF, and CYP450 variations for personalized treatment optimization.
Hands-On Clinical Training - Perform actual ketamine infusions under expert supervision in our operational clinic, gaining real-world experience impossible to replicate online
Personal Ketamine Experience - You'll undergo a supervised ketamine infusion yourself, gaining invaluable firsthand insight into your patients' journey that will transform your treatment approach and patient selection.
Target-Controlled Infusion (TCI) Mastery - Learn advanced PK modeling for precise plasma concentration targeting - true precision medicine
Elite Small Cohorts - A maximum of 4 participants per program ensures personalized, one-on-one mentoring, unlike the impersonal, unlimited online enrollment found elsewhere.
Comprehensive Mentorship - Ongoing individual guidance transforms you into a recognized authority on ketamine, not just another provider.
Whether you're just starting or seeking to enhance your current practice, this training equips you to deliver superior outcomes safely and confidently. Plus, with a full year of professional mentorship, you’ll have the ongoing support needed to master this groundbreaking treatment.
Transform your practice—enroll in the Mini-Fellowship today and become a leader in ketamine therapy.
The Precision Medicine Difference
Personalized medicine is the cornerstone of modern healthcare, and ketamine therapy is no exception. In our program, you will learn how to:
Leverage genetic insights: Understand how variations in CYP450 enzymes and NMDA receptor subtypes influence ketamine metabolism and response.
Optimize dosing: Learn to adjust infusion rates and dosing strategies based on patient-specific factors, including body mass, concurrent medications, and comorbidities.
Predict and prevent side effects: Use pharmacogenomics and clinical biomarkers to minimize adverse events and ensure a smoother treatment experience.
These advanced techniques empower you to deliver treatments that are not only effective but also well-tolerated, setting you apart as a practitioner who truly understands the science behind ketamine therapy.
What Is Target-Determined Infusion Methodology?
Unlike conventional dosing protocols, which rely on fixed-dose regimens - the "one-size-fits-all" approach- our target-determined infusion methodology focuses on achieving precise therapeutic plasma concentrations of ketamine. This approach:
Focuses on the therapeutic window and achieving optimal plasma concentrations, thereby avoiding both underdosing (which leads to inadequate results) and overdosing (which increases side effects).
Uses real-time adjustments: incorporates patient feedback and clinical observations during infusions to optimize treatment.
Individualizes every session: Recognizes that no two patients are alike and tailors every infusion to their unique needs.
This advanced methodology is exclusive to the Mini-Fellowship and is not taught in other ketamine training programs. By mastering this technique, you will achieve consistently superior outcomes and set a new standard for patient care.
A Program Designed for Excellence
The KRI "Mini-Fellowship" Intensive Training Course is the premier program for clinicians seeking to master ketamine infusion therapy. Unlike other training options, our course not only meets the rigorous standards set by the American Psychiatric Association and the American Society of Anesthesiologists but also redefines them, offering unparalleled depth and expertise.
What distinguishes the Mini-Fellowship is our relentless focus on equipping you with advanced, practical knowledge of ketamine pharmacokinetics. This empowers you to deliver safer, more effective, and better-tolerated treatments—setting your practice apart and transforming patient outcomes.
Our program offers an unmatched combination of supervised, hands-on clinical experience and a unique opportunity to undergo a ketamine infusion yourself. By experiencing firsthand what your patients will encounter, you'll gain invaluable insights that enhance your clinical decision-making and patient care.
We don’t stop at training—we invest in your long-term success. Graduates receive an entire year of personalized mentoring and professional consultation, ensuring you're supported as you navigate the complexities of ketamine therapy in real-world practice. With KRI, you’re not just learning—you’re building a foundation for excellence and leadership in this transformative field.
Become a "Ketamine Expert" and not just another "Ketamine Clinic."
Apply Now for the Mini-Fellowship
What Our Graduates Have to Say:
"Dr Grass,
I greatly enjoyed the training and found it to be detailed and oriented in a way that I could truly learn from. I raved to many of my colleagues regarding the training, including several who have Ketamine clinics. Just from the three-day course, the Ketamine providers could already tell the training I had received was leaps and bounds ahead of how they provide care.
The training exceeded my expectations. The personal Ketamine experience was a great addition to the training, and I truly believe it will aid my ability to treat my patients and share my experience with them.
Thank you again for the wonderful training."
- Shaun Madahar, MD
A Comprehensive Program to Mastering Ketamine Therapy
An Overview of Our Program:
Our 3-day intensive course is designed to provide clinicians with unparalleled knowledge, practical skills, and personal experience in ketamine therapy. Whether you're just beginning to integrate ketamine into your practice or seeking to deepen your expertise, this course offers an unmatched opportunity to become a leader in the field.
Day 1: Essential Foundations for Ketamine Therapy
Day 1 sets the stage by providing a solid foundation in both the scientific and regulatory aspects of ketamine therapy. Starting with Dr. Zarate's groundbreaking research, we explore why ketamine is a game-changer for mood disorders. You'll delve into the dual mechanisms that bridge brain chemistry with psychological well-being, understand the history of ketamine, and tackle the tough questions about its therapeutic use.
This day also highlights the importance of navigating complex regulations and ensuring compliance with governing bodies, such as the APA, ASA, DEA, and state medical boards. By the end of Day 1, you'll have the confidence to integrate ketamine into your practice safely and effectively.
Day 2: Advancing The Science of Ketamine Therapy
On Day 2, we confront the realities of current ketamine practices, exploring why "real-world" ketamine therapy often falls short. Through key studies from Yale, Harvard, and Osmind, you'll uncover the systemic issues and learn how to navigate the unregulated frontier of ketamine therapy. This day isn't just about identifying problems, but also about finding solutions.
You'll gain critical insights into the science of ketamine infusion, master pharmacokinetics, precision dosing, and understand the physiological and phenomenological responses patients may experience. By addressing the five key factors—mass, medications, medical comorbidities, metabolism, and mindset—this day ensures you're prepared to deliver the highest standard of care.
Day 3: The Next Step: Precision Medicine and Target-Determined Infusions
Day 3 focuses on the critical variables that determine ketamine efficacy and the power of personalized medicine. You'll learn how to fine-tune your approach to each patient, ensuring that therapy is tailored to their specific needs. This day covers advanced patient selection, the role of diagnostics and genetics, and the importance of biomarkers.
You'll also explore the application of precision dosing and targeted infusions across various disorders, including anxiety, PTSD, depression, fibromyalgia, and chronic pain. With a focus on real-world application and the development of advanced treatment protocols, Day 3 ensures you're fully equipped to provide the most effective and personalized ketamine therapy.
Clinical and Experiential Sessions: Gain Unmatched Expertise in Ketamine Therapy
To truly learn ketamine therapy, you need "hands-on" experience
What truly sets this course apart is the combination of rigorous clinical practice with deep personal experience. Days 2 and 3 of our ketamine training course are dedicated to transforming theoretical knowledge into practical expertise.
These sessions offer clinicians an unparalleled opportunity to engage in supervised clinical training and experience ketamine's effects firsthand. This combination of hands-on practice and personal immersion ensures that our participants develop the competence and confidence needed to excel in ketamine therapy.
Supervised Clinical Training: Mastering the Art of Ketamine Infusions
Elevate Your Skills with Real-World Ketamine Infusion Practice
Elevate Your Skills with Real-World Ketamine Infusion PracticeIn addition to our advanced didactic sessions, clinicians will receive advanced training under expert supervision, mastering every aspect of the ketamine infusion process—from meticulous pre-procedure preparation to precise infusion techniques and thorough post-procedure care.
You'll learn to create the optimal infusion environment, fine-tune dosing, and manage psychological and physiological responses during treatment. This real-world application of advanced pharmacokinetic modeling and electronic infusion records sets this course apart, providing you with the skills to deliver safe, effective, and patient-focused care.
Stepping into Your Patients' Shoes: Experience Ketamine Firsthand and Transform Your Practice
Go Beyond Theory: Experience Ketamine’s Profound Effects and Elevate Your Clinical Skills
Go Beyond Theory: Experience Ketamine’s Profound Effects and Elevate Your Clinical SkillsWhat truly differentiates this course from all others is the opportunity for clinicians to experience ketamine's profound effects themselves. By personally navigating the non-ordinary states of consciousness induced by ketamine, you'll gain invaluable insights into the patient experience.
This firsthand understanding enables you to prepare more effectively and support your patients, thereby reducing their anxiety and enhancing the treatment's efficacy. No other training program offers this level of immersive learning, making it a critical component for clinicians who aim to provide the highest standard of care.
Why Choose the Ketamine Research Institute Training Program?
In an era where mental health treatment demands innovation and precision, mastering ketamine therapy through our advanced training represents a transformative step forward for clinicians.
The Ketamine Research Institute's Mini-Fellowship delivers the most comprehensive ketamine therapy training available, combining evidence-based, experience-proven didactic instruction with hands-on clinical experience at live infusion centers. Unlike standard courses, this program teaches advanced personalized medicine approaches and precision dosing protocols that go beyond traditional one-size-fits-all methods.
Participants gain supervised clinical experience, optional personal ketamine sessions for patient perspective, and training on cutting-edge pharmacokinetic modeling—all in small groups with direct access to actual clinical settings and equipment.
What sets this program apart is its commitment to long-term success: graduates receive one year of personalized mentorship and access to an extensive referral network. Fully compliant with APA and ASA recommendations and aligned with current regulatory standards, this expert-designed program provides the advanced skills, confidence, and ongoing support necessary to deliver superior patient outcomes and establish leadership in ketamine therapy practice.
By choosing our program, you are investing in the advanced skills, knowledge, and professional development necessary to excel in ketamine therapy, setting yourself apart in a crowded marketplace and ensuring the highest quality care for your patients.
To learn more about the KRI Mini-Fellowship Program, you can visit our more extensive training program website - The Ketamine Research Institute Training ProgramHear from Our Alumni:
"Dr. Grass:
This is just a token of appreciation for your time and patience. When I enrolled in your program, it was not my intent to participate by exhaustively asking questions, but it became apparent that I had overestimated my fund of knowledge.
Although I have extensive clinical experience with ketamine, and I work at expanding my understanding of the fundamental physiology and pharmacology involved in the administration of ketamine for mental health disorders, I had no idea how much I didn't know.
All the knowledge that I had acquired needed the perspective and clinical understanding that you were willing to share. Thanks again for your help.
Your program exceeded all expectations."
— Mark Garwin, MD - Anesthesiologist
Apply Now
Our 2026 Ketamine Research Institute Mini-Fellowship Training Schedule
Upcoming Training Dates:
Upcoming Training Dates: The January session has been moved to March 19th to the 21st – Secure Your Spot Before It's Gone
How many treatment-resistant patients will you see in the next 8 weeks who could benefit from ketamine therapy? The gap between wanting to offer this treatment and being truly competent to deliver it is costing you—professionally and financially. Stop planning. Start training.
Register Now—Limited Seats Available
The Gold Standard Training That Ketamine Therapy Needs
In a field where it is estimated that less than 5% of ketamine providers meet professional safety standards, the Ketamine Research Institute takes a radically different approach. We deliberately limit enrollment to just four training sessions per year, training a total of 16 exclusive clinicians annually. This isn't a business decision; it's a patient safety imperative.
While research institutions achieve 70-75% success rates, most community ketamine clinics see results as low as 20-50% because providers received minimal training—often just online modules with no supervised clinical experience. The harsh reality: patients are dropping out at rates of 30-50%, and up to 8% are getting worse under inadequately trained providers who were misled into believing "ketamine infusions are easy... anybody can do it." They're not.
Only 16 Practitioners Per Year. By Design.
Our limited enrollment ensures what other programs cannot: genuine one-on-one mentorship, hands-on clinical training in our operational infusion center, a personal ketamine experience, and a full year of ongoing guidance as you launch your practice.
By completing the only program in the U.S. that exceeds both APA and ASA recommendations, you join an elite network of fewer than 150 practitioners nationwide who have mastered advanced pharmacokinetic modeling, precision medicine techniques, and target-controlled infusions. You don't just open "another ketamine clinic"—you become recognized as a true ketamine expert delivering outcomes that rival leading research institutions. Only 16 spots are available annually. Join the elite few who are redefining the standard of care.
Outstanding Results and Patient Safety
Better Outcomes, Higher Patient Safety Standards, and Lower Dropout Rates: The Advanced Training Difference. Many clinicians who contact us have already completed other ketamine training programs but found themselves unprepared to handle complex cases or achieve consistent results. Our graduates report significantly better patient outcomes, lower dropout rates, and greater confidence in managing the full spectrum of patient responses. They appreciate the depth of knowledge and advanced practical skills that the training provides, which are essential for achieving consistent, superior patient outcomes.
Excellence Cannot Be Mass-Produced
Ready to take the next step? You can email us at training@ketamineinstitutetraining.com or contact Charlene at 800-850-6979. She'll answer your questions and arrange for you to speak with me to discuss how our training aligns with your goals. The conversation is informal and pressure-free—we're here to ensure this training is the right fit for you."
We're not just teaching clinicians—we're cultivating the next generation of ketamine and psychedelic medicine innovators. With limited seats across multiple sessions, this is your opportunity to redefine your clinical practice and pioneer breakthrough therapeutic approaches.
Apply Now for the Mini-Fellowship
Private group sessions are available for the entire office; clinicians, nurses, and office staff are available upon special arrangement.
Download the Training Course Application
Our Goal - Train the Top 150 Ketamine Clinicians
Our goal is to train the Top 150 Ketamine Clinicians in the United States. Our graduates will become leaders in their field, highly respected ketamine experts, and serve as professional examples of clinicians providing the safest and most effective ketamine therapy available.
The "Mini-Fellowship" training program has been developed to ensure that high standards and effective treatment in ketamine therapy are maintained. Our intensive training program provides practitioners with the most up-to-date evidence-based education and training in ketamine therapy, supervised clinical experience administering ketamine therapy, and personalized mentorship available to ensure that the highest standards are met.
Our Experience and Qualifications
Gerald W. Grass, MD - Course Director
The "Mini-Fellowship" Intensive Training Program for Clinicians is a sophisticated, advanced program that builds on over 35 years of clinical research and experience in ketamine practice. Over the past three decades, I have conducted clinical ketamine research and provided thousands of hours of continuously monitored ketamine infusions to individuals worldwide, gaining invaluable experience in various clinical circumstances. Our work has been presented at national conferences and academic and governmental institutions providing educational programs in the use and future application of ketamine therapy.
Additionally, I have served as principal investigator for pharmaceutical companies conducting Phase III drug trials for psychopharmacological agents seeking FDA approval, and as a clinical advisor to various organizations and biotechnology firms.
All of this experience is then distilled down and passed on to our attendees through didactic lectures, small-group discussions, and hands-on opportunities to administer ketamine under direct supervision. We offer this wealth of experience and knowledge to participants in our program so they can return to their practices confident in their abilities to provide ketamine-based therapy safely and effectively. The bottom line is that we can provide you with the knowledge, experience, and skills to become a well-respected, successful clinician offering ketamine therapy in your community.
Ketamine Research Institute: Become a Certified Practitioner
Achieve Recognition as a Certified Ketamine Therapy Provider
Upon successful completion of this program, clinicians will receive official certification from the Ketamine Research Institute, designating them as qualified ketamine therapy providers with documented supervised clinical experience. This certification represents far more than a credential—it's your foundation for building a highly skilled and successful ketamine practice that delivers life-changing results for patients.
Join a Transformative Community of Excellence
We invite you to become part of our rapidly growing network of forward-thinking practitioners who are revolutionizing mental health care through evidence-based ketamine therapy. Our certified providers share a commitment to clinical excellence, patient safety, and innovative treatment approaches that are reshaping psychiatric care.
A Program That Sets the Standard
Our program is exceptional and exceeds all industry benchmarks for ketamine therapy training. We've designed a comprehensive curriculum that combines rigorous academic instruction with hands-on clinical experience, mentorship, and ongoing support as you launch and grow your practice. Unlike other training programs, we don't just teach theory—we ensure you gain the practical skills, clinical confidence, and business acumen necessary to thrive as a provider of ketamine therapy.
Your Path to Clinical Excellence Starts Here
Please consider joining us - we look forward to working with you!
How to Apply for Training
Download the course application here
Here's What Our Graduates Are Saying
"I thoroughly enjoyed the course and thought it was a good mix of science and practical knowledge. And of course, it was very helpful as I had no clinical experience with Ketamine and just a little knowledge from what I’ve read...
It gave me a clear road map moving forward. I’m sure there is a lot still to learn, but you never know what you don’t know until it arises. Having access to your forms, waivers, etc., is huge!
No other training offers an actual infusion for us to experience what it’s like. Having done it now, I can appreciate how difficult it would be to explain it without having done it."
— David Smith, MD - Internist/Family Practice
"Thank you so far for your help! Seems no matter how much you read and study, every patient can be different so definitely an art to this and grateful to have you as an experienced practitioner in all this.
I have also had meetings with two physicians - psychiatrist and pcp and discussed my dosing and what I’ve learned from you, and really seems that your protocol definitely provides a better sense of science and overall safety for our patients.
It’ll be great to have more providers in my local area who are on board with sending me their patients and can trust what I’m doing here. Thanks again, and I’m sure we will be in touch again soon."
— Erin Boyd, DO - Lumina Mind Health
"Dr. Grass:
This is just a token of appreciation for your time and patience. When I enrolled in your program, it was not my intent to participate by exhaustively asking questions, but it became apparent that I had overestimated my fund of knowledge.
Although I have extensive clinical experience with ketamine, and I work at expanding my understanding of the fundamental physiology and pharmacology involved in the administration of ketamine for mental health disorders, I had no idea how much I didn't know.
All the knowledge that I had acquired needed the perspective and clinical understanding that you were willing to share. Thanks again for your help.
Your program exceeded all expectations."
— Mark Garwin, MD - Anesthesiologist
Please click here to learn more about what our graduates say
To Learn More About Our Programs - please click the links below:
The "Mini-Fellowship" Intensive Training Program
A Detailed Course Overview - Elevate Your Expertise in Ketamine Therapy
Day 1: Essential Foundations for Ketamine Therapy
Day 2: Mastering the Future of Ketamine Therapy
Day 3: Taking it to the Next Level: Personalization and Precision in Ketamine Therapy
Our Course Schedule and How To Apply For Training
The Origin of Our Ketamine Training Program
What Our Graduates Say About The Course
How the Ketamine Research Institute Training Program Complies with APA and ASA Recommendations
Our Mission
The Ketamine Research Institute's mission is to train the next generation of healthcare providers in evidence-based best practices for administering safe and effective ketamine-based treatments. We are dedicated to providing clinicians with comprehensive training that is accurate, up-to-date, and clinically relevant.
