Ketamine Research Institute Training Program

"Our program represents the first standardized, Precision Medicine based ketamine infusion training course for clinicians that offers didactic, supervised clinical, and experiential training.  Our program meets or exceeds all APA and ASA recommendations while promoting more effective, safe, and uniform infusion protocols for ketamine-based therapy in the treatment of mood disorders"...

GW Grass, MD — Ketamine Research Institute

Ketamine Research Institute

The Need For Well Trained Ketamine Clinicians

During the recent COVID epidemic, depression, anxiety, and post-traumatic stress disorder rates have all risen dramatically. Media outlets have been educating the public about the tremendous therapeutic benefits of ketamine and other psychedelics for the rapid relief of mood disorders and related conditions.

Health insurance companies in both Canada and the U.S. have taken notice and may soon start covering ketamine-based therapy treatments. As awareness grows around this new treatment breakthrough, many more people who suffer from mental health issues will be able to benefit from ketamine-based therapy that has been proven to be effective. As a result, there is a tremendous need for qualified medical professionals trained to provide patient-centered, safe, and effective ketamine therapy for mood disorders.

As you may already know, many organizations are providing various forms of ketamine training. Unfortunately, the quality of these programs varies considerably, and it is difficult to determine which ones are reputable and offer comprehensive instruction. Many are conducted "online" and do not offer the APA-recommended supervised "hands-on" ketamine infusion experience necessary to provide safe and effective patient care. Often, the programs are led by multiple clinicians with varying levels of clinical knowledge or experience. This can make it very difficult to form a cohesive and effective understanding of ketamine therapy.

Similarly, by relying on simple mg/kg dosing protocols without a firm foundation in the pharmacologic principles underlying ketamine therapy, including the pharmacokinetics and pharmacodynamics of ketamine, wide variations in plasma concentrations of ketamine can occur increasing the likelihood of adverse effects or poor outcomes.

Perhaps most importantly, no other ketamine infusion training program provides clinicians an opportunity to personally experience a ketamine infusion for themselves. This is crucial to understanding the distinct nature of ketamine therapy and how it is significantly different compared to any other medical practice or procedure.

Our Program is Unique

Our training program is one-of-a-kind, custom-tailored, and specific to the professionals' intended use of ketamine-based therapy. It is particularly well suited for clinicians who are new to this modality and are interested in adding ketamine-based therapy to their practice as a rapidly effective treatment for various mood disorders, including depression, bipolar disorder, anxiety, and PTSD. It is conducted "on-site" and "in-person" in our infusion center, which allows you to become familiar with the environment in which infusions are performed, as well as get first-hand experience with all the necessary monitoring equipment, intravenous delivery systems and supplies necessary for the safe administration, storage, and handling of ketamine.

Unlike other programs, our course provides a detailed understanding of the inherent but often overlooked intrinsic limitations of the standard ketamine infusion developed at Yale in 1994.  This knowledge is critical to achieving the best therapeutic benefit for your patients. Unfortunately, many clinicians providing ketamine therapy may lack this understanding, resulting in outcomes which fall far below what is reported in the scientific research literature.

We employ a highly practical and "in-depth" approach to ketamine therapy, using basic and advanced principles of pharmacokinetics and pharmacodynamics.  This includes utilizing Precision Medicine and Target-Controlled Infusions to overcome limitations of the "standard" infusion and significantly improve the effectiveness of ketamine therapy — optimizing your ability to achieve success with your patients. We believe that providing safe, more effective, and better-tolerated ketamine infusion therapy is essential to become recognized as a highly skilled and successful clinician rather than just another "ketamine clinic."

The "Mini-Fellowship" Intensive Training Program For Clinicians 

A Comprehensive — APA/ASA Compliant — Didactic, Supervised Clinical, and Experiential Training for Clinicians

Our 3-day "Mini-Fellowship" Intensive Training Program was developed to fill that need and designed for clinicians seeking to provide this remarkably effective new treatment option to their patients who are new to ketamine-based therapy and infusion procedures.

Clinicians who complete our course will know all aspects of ketamine administration, from practice integration and indications/contraindications to storage, handling, and documentation. We also provide a comprehensive course manual that summarizes all the lectures and presentation concepts. It includes pertinent scientific references, examples of all required DEA documentation, treatment consents, medical evaluations, and records to use and adapt in your practice. After completing this course, graduates will be certified by the Ketamine Research Institute as qualified ketamine therapy clinicians with supervised clinical experience.  In addition, you will also have access to our referral services network and personal mentoring to confidently start your ketamine infusion practice.

Ketamine Infusion Therapy for Mood Disorders - A 3-Day "Mini-Fellowship" Intensive Training Course

We believe our program is exceptional and exceeds consensus recommendations published by the American Psychiatric Association and the American Society of Anesthesiologists, including the clinical component of ketamine infusion therapy. We are committed to helping clinicians learn how to provide these treatments safely and effectively.

Training Schedule for 2023

January 19th through the 21st - One available opening

April 20th through the 22nd - Three available openings

July 20th through the 22nd - Five available openings

October 19th through the 21st - Six available openings

Become a Certified and Well Qualified Ketamine Infusion Therapy Clinician.

Our training programs provides the knowledge, tools, and clinical training necessary for our graduates to achieve the same "remarkable" levels of improvement (70-75% improvement following ketamine infusion treatment) seen in well-controlled, high-level research studies. In addition to increase clinical effectiveness our graduates report high rates of completion, and few, if any, "adverse effects" by using Precision Medicine and Target-Controlled Infusions.  This advanced approach and optimized treatment protocol provides up to a 50% greater effectiveness than the Standard Ketamine Infusion can achieve in "real-world" clinical practice settings for significantly improved patient outcomes and satisfaction.

To learn more about our unique program, please read: The Origin of Our Ketamine Training Course below.

Additional — New and Expanded Training Opportunities for 2023

Due to the increasing need for well-qualified and certified Ketamine Infusion Therapy clinicians, the Ketamine Research Institute will be expanding our training program for clinicians in January of 2023 to four sessions per year with a total of 24 available clinical positions. The new course offers you the opportunity to gain full understanding of the complex Pharmacokinetics and Pharmacodynamics of ketamine in addition to the recommended supervised "hands-on" clinical training. A unique aspect of our training which further sets it apart from all others is the opportunity personally experience a ketamine infusion and gain additional proficiency in administering ketamine infusions to patients.

For clinicians already employing ketamine therapy in their practices, we will be adding a specialized advanced course for those who want to expand their skills by utilizing a new methodological approach to ketamine therapy — Target-Controlled Infusions and Precision Medicine — to achieve significantly improved patient outcomes and therapeutic responses, up to a 50% improvement over those of the  standard ketamine infusion when used in the community setting.

New: Ketamine Training for Experienced Ketamine Providers and Anesthesiologists.

If you are an experienced clinician who wants to learn more about how to optimize ketamine therapy for your patients and take your skills to the next level, our "Advanced Clinician" training program provides the in-depth knowledge, tools, and training necessary for our graduates to achieve the same "remarkable" levels of improvement (70-75% improvement following ketamine infusion treatment), high rates of completion, and few, if any, "adverse effects" as those reported by the most sophisticated, high-level research programs.

You will gain insight into the Pharmacokinetics and Pharmacodynamics of ketamine coupled with the use of Target-Controlled Infusions and Precision Medicine to achieve up to 50% greater effectiveness than the Standard Ketamine Infusion can achieve in "real-world" clinical practice settings. This advanced 2-day didactic program that will provide you with the skills and experience necessary to become a more successful provider of ketamine therapy.

NEW: Improving Ketamine Assisted Psychotherapy through the use of Precision Medicine and Target-Controlled Administration Techniques.

This advanced course is for clinicians currently using KAP who are not satisfied with the short duration of therapeutic engagement provided by multiple IM injections of ketamine or subpar response rates.

This unique training opportunity provides clinicians with the ability to accurately determine the therapy interval needed, while patient ketamine concentrations are maintained at an optimal steady state for psychotherapy. This protocol also enhances the ED50 pharmacological aspects of ketamine-based therapy to greatly improve patient engagement and overall therapeutic response rates.

The Origin of Our Ketamine Training Course:

The Mini-Fellowship" Intensive Training Program for Clinicians is a  sophisticated and advanced  training program that results from over 35 years of my clinical research and experience in ketamine practice, personally administering ketamine-based therapy to treat a wide variety of complex and challenging medical and mental health issues. Because of our expertise and accomplishments in ketamine therapy, patients and practitioners have come to us from around the world seeking help.

That experience, knowledge, and expertise have formed the basis of our ketamine training program. Unlike any other program, we provide each of our clinicians with "one-on-one" individualized training in an actual ketamine infusion center environment and the necessary real infusion experience to fully understand and appreciate the full therapeutic potential of ketamine therapy.

We've learned that this type of immersive and "practical" ketamine training center environment is superior to online video formats or sterile classroom instruction in acquiring useful clinical information and real-world experience with ketamine therapy. Our program may be best characterized as a "mini-fellowship" clinical training program in ketamine infusion therapy coupled with ongoing mentorship, clinical support, and direct access to our core group of experts and me long after the initial training period.

Current research suggests that many of the centers and clinics offering ketamine infusion therapy have incredibly high "dropout" rates, relatively poor outcomes in which only 20-50% of their patients benefit from the treatment, and seem to have an unusually high incidence of "adverse effects."  Our training program provides the knowledge, tools, and skillsets necessary for our graduates to achieve the same "remarkable" levels of improvement (70-75% improvement following ketamine infusion treatment), high rates of completion, and few, if any, "adverse effects" as those reported by the most sophisticated, high-level research programs through the KRI Enhanced Ketamine Protocol.

We are confident that no other ketamine training program in the United States can provide the depth of material, sophisticated approach to ketamine therapy, clinical experience, and ongoing support required to become highly proficient in this cutting-edge treatment that we provide.

Gerald W. Grass, MD - Course Founder

The Early Days

The ketamine infusion protocol, used by almost all practitioners worldwide today to treat depression, was discovered at the Yale University School of Medicine/West Haven, Connecticut VA Hospital over 25 years ago. It was my former Department at Yale (Anesthesiology) that formulated and administered the very first ketamine infusion treatment, which has since become known as the "standard" ketamine infusion and is now used by many others around the world, including many prestigious Academic Medical Centers such as Harvard, Yale, Columbia, and the National Institutes of Mental Health (NIMH).

Although I first became acquainted with the clinical use of ketamine in 1985, the early underpinnings of our current training program began in 2002 during my time at the Mount Sinai/NYU Medical Center. They later became more formalized in 2007 as part of my teaching responsibilities at Yale University Department of Anesthesiology. As an Assistant Professor in the Department of Anesthesiology, Director of the Pain Medicine Fellowship Program, and Chief of Pain Medicine for the Connecticut VA Healthcare System, in addition to my clinical duties and research, I was responsible for educating Anesthesiology Residents and Fellows in Pain Medicine.

I included didactic lectures, demonstrations, and hands-on training in administering high-dose ketamine infusions for chronic neuropathic pain conditions as part of my curriculum. In addition to teaching Residents and Fellows, I also conducted clinical research on the therapeutic basis of ketamine therapy. I provided instruction to Attending Physicians, Administrators, and Researchers from the V.A. nationwide and Physicians in the Department of Defense on the remarkable potential of ketamine in treating returning veterans with complex physical and psychological injuries.

Innovation and Evolution of Ketamine Therapy

That early program has evolved significantly over the years. I have accumulated thousands of hours of direct, "hands-on" ketamine infusion time with patients worldwide who have come to us with widely varied clinical presentations and co-morbid conditions for treatment.

It became apparent that the simple infusion protocol of 0.5mg ketamine per kilogram given intravenously over 40 minutes, which has become the "de facto" standard ketamine infusion treatment for mood disorders, is not as effective in clinical practice as it is in well-controlled research studies. Why is that?

What other factors and considerations need to be accounted for to improve the therapeutic benefit of ketamine?

There were many questions but few answers. For example, what patient selection factors must be considered to obtain the best results, and do many patients' medications interfere with ketamine? Should individual variations in patient metabolism and genetics be considered when determining the dosage of ketamine?

Then there was the issue of "set and setting" and how to best prepare a person to undergo and benefit from the unique psychological and phenomenological ketamine experience. What should the environment look like, should someone always be with the person during an infusion, and what music or visual imagery should you use. Can we monitor their internal states in some way? Answering these issues became a prolonged investigation of its own.

How to Improve Ketamine Efficacy and Outcomes.

Over the years, we have been able to find some of those answers and implement them effectively into a more evidence-based approach to ketamine therapy. That knowledge and experience have been condensed and distilled into our current training course. The training that we provide is conducted in our ketamine infusion center in Sarasota, FL., so that you can see and experience the process of ketamine infusion therapy on a firsthand basis.

The program is focused on and intended to train a core group of Physicians, Nurse Practitioners, CRNAs, and allied medical clinicians to provide the highest quality, evidence-based, optimized, and enhanced ketamine therapy available to patients in their current office or outpatient practice setting.

We believe that our three-day intensive course with personalized, one-on-one training, actual infusion experience, and continuing personal guidance is a unique and invaluable component to this training program and our student's success utilizing this cutting-edge therapy.

"It is our opinion that no other ketamine infusion training center or course can provide this level of expertise and experience."


Course Rationale:

During the recent COVID epidemic, depression, anxiety, and post-traumatic stress disorder rates have all risen dramatically. Media outlets have been educating the public about the tremendous therapeutic benefits of ketamine and other psychedelics for the rapid relief of mood disorders and related conditions.

Health insurance companies in Canada and the U.S. have taken notice of this new treatment modality and may soon cover such treatments. As this evolution unfolds, many more individuals in need of a new and effective treatment option for mental health issues will benefit from ketamine-based therapy.

The "Big Business" of Ketamine Therapy.

Although ketamine infusion therapy is remarkably rapid and effective in improving patients with treatment-resistant depression under strict research conditions, that is not always the case in actual clinical practice.

Unfortunately, some clinicians who provide ketamine therapy, and now investment bankers and venture capitalists are seeking to "commercialize" ketamine treatment and appear to be doing so without having the necessary clinical knowledge of the complexities of this cutting-edge therapeutic modality. As a result, they have engaged what some view as questionable medical practices and treatment outcomes are frequently not as good as they might be.  And this is a concern for all of us.

Some Ketamine Treatments May Not Be As Effective As You Think.

Although numerous research studies conducted over the past 20 years have shown that ketamine infusions can be effective for 70% - 75% of "research subjects" who have not responded to any other treatments or antidepressant medications — it is important to understand that "research subjects" are not the same as "real-world" people — and it may surprise you to learn that "real people" often do not respond to ketamine infusion nearly as well as those in research studies.

Our experience, and that of others, suggest a more realistic number would be only 40-50% of people respond to ketamine infusions when administered in a community setting (1). In fact, according to recent research studies, just 18.3%* - 45.5%* of patients with treatment-resistant depression responded favorably after six infusion sessions in a community hospital setting (2).

There are many reasons for the lower response rate; some typical factors include a lack of training and experience in administering ketamine, failure to adhere to strict patient selection and treatment standards, and failure to appropriately adjust ketamine dosing based on the patient's medications, metabolism or genetic profile.

For example, according to a study published by the Osmind Corporation (3) of 9016 patients who received ketamine infusion therapy from 178 community based providers only 6% (537) completed the initial phase of treatment and met the minimum required study treatment standards. Approximately 61% dropped out of treatment prior to completing the initial phase of infusions.  Of those who completed the initial phase, most discontinued treatment within 6 months, and as many as 8.4% became worse following ketamine infusion therapy.

What Is Currently Needed.

As a result, there is a tremendous need for qualified medical professionals trained to provide patient-centered, safe, effective ketamine therapy for mood disorders. This 3-day intensive program aims to provide clinicians with the necessary skills, understanding, and knowledge to administer a superior and optimized ketamine infusion to their patients in an office or outpatient setting. The program covers all aspects of ketamine therapy that have practical clinical applications today and in the future.

Ketamine Physicians, Accredited Practitioner Certified Ketamine Infusion Therapy logo with Doctor Grass Sarasota Florida


Course Overview

With a focus on clinical efficacy, safety, and patient welfare, the Ketamine Research Institute's program trains participants to safely administer ketamine-based therapy to patients with various mood disorders. This therapeutic approach is now widely recognized to have remarkable effects on treatment-resistant depression, bipolar disorder, post-traumatic stress disorder (PTSD), obsessive-compulsive disorder (OCD), and some forms of chronic pain.

An additional goal of this training program is to train nurses, psychologists, and other medical and mental health clinicians, to explore new treatment options that will be more effective than traditional treatments currently being used.

The course trains participants to safely and effectively administer the ketamine infusion protocol developed at Yale in 1994-2000 and currently used by the National Institute of Mental Health, Academic Centers, and Major University Medical Centers worldwide.

Special Note: This course goes beyond the original limited protocol by training professionals to provide a more sophisticated approach to ketamine infusion therapy. One that we have found to be more effective, versatile, and cost-effective for your patients.

Course Format:

Our ketamine therapy program is conducted in an actual ketamine infusion center setting. Participants will learn while getting to know the equipment, monitoring devices, and layout of an existing ketamine infusion center.

Small Group - One-on-One Attention

Our course is usually limited to only three practitioners at one time to facilitate a small group learning environment, active discussion, and adequate familiarization with an actual ketamine infusion center.

While with us, clinicians can become familiar with and use all of the necessary monitoring equipment, venous access technologies, intravenous delivery systems, and supplies necessary for the safe administration, storage, and handling of ketamine.

Hands-On Clinical Experience

We have found that this type of immersive and practical ketamine training center environment is better suited to gaining valuable clinical knowledge and actual experience in ketamine therapy than can be provided by online video formats or sterile classroom instruction.

Our intensive training course is a unique educational experience. The course content is comprehensive, extensive, and highly practical; the content of the curriculum is also dictated by the needs of the individuals taking the course.

Personalized To Your Needs

To the degree possible to maintain our educational objectives, the 3-day intensive training is customized to each practitioner's needs and skill level. It delves deeply into specialized aspects of ketamine pharmacokinetics and pharmacodynamics, including the effects of patient-specific metabolism, medication interactions, and genomic variables that can affect ketamine metabolism and efficacy.

Ketamine Infusion Experience

A unique aspect of the Ketamine Research Institute program is that clinicians who undertake the intensive training are also provided with the opportunity to experience a ketamine infusion first-hand to fully understand this remarkably versatile medication's unique psychological benefits and therapeutic potential.

APA and ASA Training Guidelines and Recommendation

All of our training meets or exceeds the consensus recommendations published by professional organizations such as the American Psychiatric Association and the American Society of Anesthesiologists. Clinicians who complete the course are provided with the comprehensive course manual, which summarizes all of the lecture and presentation concepts and provides the necessary scientific references supporting ketamine therapy.

Also included are examples of required DEA documentation, treatment consents, medical evaluation, and treatment records. In addition, participants are provided with certification of training by the Ketamine Research Institute and personal assistance during the initiation phase of their ketamine infusion practice. They are invited to participate in our ongoing discussion board and chat group.

Course Objectives:

The course is highly comprehensive and practical in its approach. It includes a detailed didactic component that gives the practitioner a broad overview of the evolution of ketamine therapy and insight into future clinical applications, including neurodegenerative disorders, inflammatory conditions, and substance abuse disorders. Much of our time is devoted to understanding ketamine therapy from pharmacologic, physiologic, and phenomenological perspectives.

Understanding the Principles and Foundation of Ketamine Therapy

We thoroughly cover appropriate patient selection and preparation issues, essential safeguards/precautions, and follow-up or transitional care. The unique aspects of ketamine pharmacokinetics and pharmacodynamics, including the effects of patient-specific metabolism, medication interactions, and genomic variables, are covered in-depth. Understanding these concepts directly impacts the success or failure a practitioner may encounter in a clinical setting and provides the necessary flexibility to modify infusion protocols and treatment regimens to improve outcomes in challenging cases.

Practical Clinical Aspects of Ketamine Treatment

Practical considerations include supplying the student with the tools, information, and resources necessary to undertake ketamine-based therapy, including the prerequisite equipment and supply requirements, staffing requirements, drug acquisition, and DEA safe storage and recording procedures. Also, each student is provided with numerous examples of medical documentation necessary for initial patient contact and evaluation, consent forms, procedure notes, infusion records, and follow-up protocols.

Ketamine Infusion Therapy for Mood Disorders 3-Day Intensive Course

The Ketamine Research Institute training program is ideal for clinicians and other medical/mental health experts interested in ketamine as a primary treatment approach for various clinical issues, including mood disorders, addiction issues, and neurodegenerative/inflammatory/functional illnesses.

We understand that ketamine therapy is unlike any "standard" medical procedure and that a cookbook — "one-size-fits-all" — ketamine infusion protocol approach does not work well for everyone.

The Benefits of Our Training Program

The course not only covers all of the practical aspects of ketamine therapy and ketamine-assisted psychotherapy but expands into scientific principles allowing optimization of the basic protocol. It focuses on in-depth and practical techniques which will enable flexibility when administering ketamine based on the unique circumstances of each patient.

Learn While Doing - Gain Clinical Experience

More than that, we believe that the specialized skillset and practical experience required for the safe and effective administration of ketamine infusion therapy cannot be learned from an online video presentation or in a formal classroom setting.

Therefore, our course training is conducted in person - in a small group seminar format - and all learning takes place “on-site” in an actual infusion center. This real-world environment allows you to become familiar with how infusions are actually performed and provide "hands-on" demonstrations of the necessary monitoring equipment, venous access devices, intravenous delivery systems, and supplies essential for the safe administration, storage, and handling of ketamine.

Ketamine Research Institute Personal Mentoring

With an evidence-based, adaptable approach to ketamine therapy and practical experience in administering ketamine infusions and ongoing clinical support, our training program provides the optimal opportunity to rapidly achieve clinical proficiency and expertise.


Ketamine Infusion Therapy for Mood Disorders

3-Day Intensive Course

Our course not only covers all of the practical aspects of ketamine therapy but expands into scientific principles allowing optimization of the basic protocol.  All course training is conducted “on-site” in an actual infusion center so that you will have an opportunity to become familiar with the environment in which infusions are performed. This includes a demonstration of the necessary monitoring equipment, intravenous delivery systems, and supplies necessary for the safe administration, storage, and handling of ketamine. 

How to effectively integrate ketamine therapy into your current practice

Download Course Brochure



Intensive Course Description - Current Content 2022

The Ketamine Research Institute ketamine-assisted therapy training course content is comprehensive and integrated. It systematically embraces all major aspects of ketamine therapy/psychedelic therapy and emphasizes the incorporation of ketamine-assisted therapy into contemporary professional practice.

Module 1 - A New Way of Looking at The Treatment of Mood Disorders

  1. Introduction – Gerald W. Grass, MD
  2. Are Conventional Antidepressants Obsolete?
  3. Ketamine - A Master Molecule for Rapid Improvement in Mood Disorders
  4. The Human Connectome Project and How It Impacts Mood Disorder Treatment
  5. Ketamine as a form of Multimodal Neuromodulation Therapy
  6. Why You Should Perform Ketamine Infusions in a private practice setting
  7. Question and Answer Session

Module 2 -The Current Scientific Evidence Supporting Ketamine Assisted Therapy

  1. What is Ketamine – The Strange History of CI 581
  2. Summary of the Current Scientific Evidence for Ketamine Therapy Part 1
  3. Summary of the Current Scientific Evidence for Ketamine Therapy Part 2
  4. Pharmacodynamics and Pharmacokinetics Aspects of Ketamine Therapy.
  5. Beyond the Pharmacological Effects of Ketamine – Transpersonal Perspectives
  6. Research into Other Ketamine-like Compounds – Will They Be Effective?
  7. Should You Consider Incorporating Other Psychedelic Agents in Your Practice?
  8. Question and Answer Session

Module 3 - Practical Clinical Aspects of Ketamine Assisted Therapy

  1. How to Choose the Right person and Right Condition for Ketamine Assisted Therapy - Not Everyone is a Good Candidate.
  2. Medical Records, labs, and Prior Treatments – What's Important and What is Not.
  3. Contraindications to Ketamine Assisted Therapy - When To Be Very Careful.
  4. Medicolegal Concerns about Off-Label Use of Ketamine and Psychedelic Therapy.
  5. The Best Way To Administer Ketamine: Intravenous vs. Intramuscular vs Oral/Nasal.
  6. Is Ketamine Abuse and Substance Dependence An Issue?
  7. Question and Answer Session

Module 4 - The Ketamine Infusion Protocol and Procedure

  1. Pre-Procedure Assessment and Documentation Requirements
  2. Equipment Requirements Necessary for Providing Ketamine Safely
  3. Fundamentals of Anesthesia Monitoring and Intravenous Therapy
  4. Patient Monitoring Requirements for Infusion Therapy
  5. Adverse Effects Associated with Ketamine and How to Manage Them Effectively.
  6. Procedure Observation and Post-Infusion Interview
  7. Question and Answer Session

Special Section - Participate in an actual Ketamine Infusion/Personal Ketamine Experience.

While other training programs focus solely on the scientific and clinical aspects of ketamine therapy, we go beyond presenting mere technical information to provide the necessary "hands-on" practical experience in administering ketamine infusions that are required to become proficient.

The ketamine infusion experience can be a profound and life-changing event for many people. Most importantly, and unique to our training course, practitioners are also given the opportunity and encouraged to experience a ketamine infusion themselves to fully understand and appreciate the unique psychological environment which their patients will experience.

This one-of-a-kind experience will allow the clinician to personally relate to your patients' pre-infusion anxieties and concerns about ketamine therapy and provide first-hand accounts of what the experience is like. More than that, it provides you with invaluable personal insights into the phenomenological environment of ketamine-assisted therapy and enhances your understanding of the unique therapeutic potential of ketamine.


Module 5 - Optimizing Outcomes and Expanding Indications for Ketamine-Assisted Therapy

  1. Optimizing Serum Concentration for Maximal Benefit.
  2. Special Considerations for Ketamine Assisted Psychotherapy (KAP therapy).
  3. Medications, Metabolism, and Genetics = Make or Break Treatment Outcomes
  4. Treating Complicated Patients with Mood Disorders and Other Mental Health Issues
  5. How to Monitor Treatment Effectiveness and Outcomes.
  6. Beyond the Recognized Benefits of Ketamine – The Master Molecule
  7. The Expanding Indications for Ketamine Therapy.
  8. Is Ketamine really a "Dissociative" Medication - Or is it more "Psychedelic" than Psilocybin or LSD?
  9. Psilocybin, LSD, DMT, and Ayahuasca – Psychedelics May Not Be That Magical After All
  10. Question and Answer Session

Module 6 - Establishing A Ketamine Therapy Program in Your Existing Practice Setting

  1. Establishing A Ketamine Assisted Therapy Program in Your Current Practice Environment.
  2. Creating A Scalable Infusion Program for New and Existing Patients.
  3. What are the Start-Up Costs Involved in beginning Ketamine Therapy
  4. How to Make It More Affordable for Patients?
  5. Recommendations for Space, Staff, Supplies, Equipment, and Vendors.
  6. Educating colleagues, patients, and referral sources about ketamine-based therapy.
  7. Ketamine Institute Mentoring Program

After this program, participants will be able to:

— Understand the rationale for using ketamine infusion therapy for mood disorders and the mechanism of action of ketamine as an antidepressant.

— Safely administer ketamine infusion therapy to patients with mood disorders using the National Institute of Mental Health/Yale Protocol

— Identify and manage potential adverse effects associated with ketamine infusion therapy.

— Understand the principles of pharmacokinetics and pharmacodynamics as they relate to ketamine

— Develop a patient care plan for administering and monitoring ketamine infusion therapy in collaboration with a qualified medical professional.

— Optimize treatment outcomes through practical strategies such as dose titration, metabolic optimization, and other psychotherapeutic augmentation techniques.

— Establish and Manage a "State of the Art/Best Practices" Ketamine Infusion Center.

Who Should Attend

The number of organizations and groups offering ketamine training has risen as interest and popularity in ketamine and psychedelic therapy have grown. Some, of course, are better than others and each may focus upon different applications of ketamine assisted therapy. It is essential to us that the type and nature of the training be appropriate for a clinician's skill set and unique requirements.

Our training course will be better suited to those clinicians who wish to employed ketamine therapy as:

A Primary Treatment Modality:

Our ketamine-assisted therapy training course is particularly well suited for clinicians and other medical/mental health professionals interested in ketamine-based therapy as a primary treatment approach for a variety of clinical problems including mood disorders, addiction issues, and certain neurodegenerative/inflammatory/functional diseases. It emphasizes an in-depth and practical approach to ketamine therapy utilizing knowledge of the underlying principles of ketamine therapy.

This establishes a firm foundation for knowledge and, when combined with practical clinical experience administering ketamine and ongoing clinical support in administering ketamine therapy, provides the best option for developing clinical proficiency and expertise.

Or as Adjunctive Therapy for Multimodal Practices:

For psychiatrists and other medical professionals who wish to utilize ketamine therapy as a supplement to their current therapies such as psychotherapy, rTMS, or ECT - we provide an in-depth approach that will facilitate early implementation of a safe, standardized, and effective treatment modality.

Other Training Programs May Be More Suitable:

For those who do not require a personalized or practice tailored approach, ketamine infusion experience, an optimized infusion protocol, or ongoing clinical support; a training program such as the one provided by IPI/ASKP3 - Ketamine Medical Provider Online Training - or other similar programs may be adequate for their needs.

For Those Primarily Interested in KAP, We Suggest Other Options:

Physicians/Clinicians and other licensed psychotherapists who specialize in neuropharmacology and/or psychotherapy who wish to utilize ketamine as a therapeutic tool during therapy sessions may find the training provided by Phil Wolfson's group, The Ketamine Training Center, to be the most suitable for these situations.

Course Application and Fees:

How to Apply:

To apply for the course, please contact us by email indicating your interest in ketamine-based therapy and how you plan to integrate into your current practice environment and we will arrange to speak with you personally about the course and answer your questions.

Alternatively, if you are committed to training with us then feel free to download, complete, and return the Training Brochure/Application and email it back to us. In addition, please also submit copies of your current active medical/professional licensure, a resume of formal training, including ketamine infusion therapy, if any; and a brief but thoughtful explanation of your interest in and planned use of ketamine-based therapy.

You may send the materials to us by email at or by Fax at 850-602-9013.

After You Submit an Application:

Once all of the documentation has been received and reviewed, we will arrange a convenient time to discuss your application, answer any preliminary questions you may have, and provide you with additional details about the program.

Once Accepted:

Before beginning the course, it is helpful to have as much background in ketamine therapy as possible. Many physicians have a naïve view that a ketamine infusion is a simple procedure that support staff can perform and monitor while the clinician is attending to other concerns. That belief has led to the proliferation of "ketamine clinics" that often provide substandard care and have inconsistent or poor outcomes.

I believe that to do anything well and have consistent success with your patients, the more you understand the underlying pharmacodynamic and pharmacokinetics involved, the better able you will be to deal effectively with your patients. Particularly those more challenging and complex cases that will present to your office over time.

To help in that regard, we recommend that clinicians who attend the course consider reviewing certain preliminary information that provide essential background knowledge which they will find very helpful to fully benefit from our course and later daily practice situations.

  2023 Training Program Schedule

Application to the course does not guarantee acceptance. All applications for training are reviewed and the class roster is filled on a rolling basis. The course typically fills early and it is beneficial to submit your application as soon as possible.

Physicians/Clinicians - Usually limited to 6 Clinicians

Our Program Includes: Everything you need.

— The Comprehensive Course Manual and References.
— Examples of Patient Selection/Screening Criteria, Office Procedures, Medical Documentation, Infusion Records, DEA Controlled Substances Log, and Administration Record Forms.
— Ketamine Infusion Protocols, Procedures, and Policies.
— Pharmacokinetic Calculator recommendations, Adjusted Body Weight/Composition Calculations, and Drug/Drug Interaction Guides.
— Guidelines for Vendor Selection, Supplies, Equipment, and Monitoring Equipment.
— KRI Standards for a Ketamine Infusion Center. Space, equipment, supplies, and staffing recommendations.
— All participants are provided with certification of training by the Ketamine Research Institute.
— Lifetime Personal Mentoring and clinical advisement practice and ongoing lifetime participation in private group discussion and core group advisement sessions.

The registration fee for the 3-Day "Mini-Fellowship" Intensive Training Course for Clinicians is $8950.00.

PAYMENT POLICY - You will not be billed until formal acceptance has been granted. Upon completion of the telephone interview and formal acceptance into the course a $2,500.00 deposit will be charged. The balance of $6,450.00 will be due, in 2 installments, 30-days and 14 days prior to your course start date. Should you need to cancel within 14 days or less of the course start date, you will receive a full refund of any fees paid less your initial deposit of $2500.00.

Nurses/Psychologists/Other Clinicians - available by special request only

This course is specifically tailored to each attendee's needs and anticipated role in providing ketamine-based therapy. It is therefore essential that we understand and discuss your specific clinical scenarios, treatment objectives, learning requirements so that we can ensure you receive the greatest benefit from our program.

Please contact us directly by email to arrange a time to discuss your interest in ketamine-based therapy.

Please Note:

Accommodations are not included; however, a discounted rate is available for our colleagues with our partner hotels including the Hampton Inn, Ritz-Carlton, and Hilton Art of Ovation hotels.

Please be aware that the course does not focus on the RESTORE infusion process which is proprietary to the Ketamine Research Institute. Although much of the course centers around the core concepts and principles used to develop RESTORE and it is therefore our policy to ask all attendees to sign non-disclosure agreements prior to the start of the course.

Individual, Institutional, and Governmental Intensive Training

sessions are available by special arrangement.

For additional information, please contact us at:

Or download the program brochure and fax all required documents to:


What Our Graduates Are Saying

"I am an Austrian psychiatrist. One year ago, I started using ketamine for the treatment of my depressive patients without formal training using the standard protocol published in the literature.  I decided to attend the Ketamine Institute’s training program to enhance my skills.

The Ketamine infusion therapy for mood disorders” training course for physicians went above and beyond my expectations. Dr. Grass' brilliance and profound professional expertise made this course an unforgettable and truly eye-opening experience. I can now understand Ketamine from a pharmacological, anesthesiology, psychiatric, medico-legal and therapeutic perspective. I could put the contents I learned immediately into practice and my patients are already profiting from the knowledge I gained."

Since completing the course, Dr. Landauro writes…

"I arrived safely to Salzburg yesterday. Today we are performing our first optimized ketamine infusion. My patients and I are excited about this.

I treated the first wave of my ketamine eligible patients. Last Friday I talked to Ingrid. She couldn’t stop thanking me. To be sincere, I would have never thought any kind of improvement to be possible in her case. Ingrid’s depression is cracked - not in remission - but really cracked. 40 years of treatment from some of the greatest minds in the country couldn’t do the trick; the brilliant new protocol I learnt from you did. She had her first “not very painful 2 weeks” she can remember. She still complains, she still feels bad - but not so bad. I will come back to Ingrid later…

The sheer fact that I have the option to apply the optimized protocol gives my clients strength. It’s a whole new experience for them when I tell them “you don’t have to suffer longer than you want to.” I make them aware that we can “eradicate” 80% of depressions in a week. It gives them confidence and a reason to hope.

I went to Florida to learn how to give infusions properly, I came back with a huge arsenal of psychiatric-psychotherapeutic power-tools.

I wish you would have heard Ingrid saying…
…thank you!"

-Dr. Med R Febres Landauro – Saltsburg, Austria

"Dr. Grass:

This is just a token of appreciation for your time and patience. When I enrolled in your program, it was not my intent to participate by exhaustively asking questions, but it became apparent that I had overestimated my fund of knowledge.

Although I have extensive clinical experience with ketamine, and I work at expanding my understanding of the fundamental physiology and pharmacology involved in the administration of ketamine for mental health disorders, I had no idea how much I didn't know.

All the knowledge that I had acquired needed the perspective and clinical understanding that you were willing to share. Thanks again for your help.

Your program exceeded all expectations"


Mark Garwin, MD - Anesthesiologist


"Thank you again for an informative, enlightening, and practical course! Christy and I thoroughly enjoyed our experience with you, and we are excited to get all of our ducks in a row to get started with the ketamine infusions for mood disorders.

We appreciate your offer to send your forms/documents in a pdf as this will give us a great start in providing the right documentation, consent, etc… which interestingly our malpractice carrier is requesting. (I guess PA is not as progressive as FL.)

The course was fantastic….exactly what I was hoping for….evidence-based, scientifically yet practically oriented…allowing us to not only understand the basics of these treatments but some insights as to improve our successes and minimize the “failures” through careful patient selection and optimization.

I am looking forward to applying what we have learned to improve the lives of those in our community who qualify for this treatment and approach! We again thank you for the opportunity and look forward to staying in touch!"

Theresa Burick, MD - Integrative Medicine Specialist

"The course was absolutely helpful! I needed this information to know how to start. Now I know what I need to obtain. However, I may still approach you when I have my first actual patient scheduled later this year and I would love some peer support from you and the others.

I felt I needed the hands-on information to be able to know what my clinic should be like, and now I have a lot of ideas. Also, I needed the scientific approach of how to calculate/know what plasma concentration can work for whom and how to possibly change it. Now I have something better I can work with than the Yale protocol as an IM or trochee dose (never seemed optimal and nobody explains it - yet people do whatever).

As I am not a psychiatrist or anesthesiologist I knew I had to do this training to cover my ass and I am grateful I did. I believe everyone working with Ketamine should experiment with it and other psychedelics. Nevertheless, you have to experience it to be able to serve others appropriately. Thanks for offering access to a personal experience, even for those who would not consider it otherwise.

Rixt Luikenaar, MD - OB/GYN, Transgender Specialist


"The course was Fantastic. Thorough without drawing in details. Fluid and open to conversation. Extremely helpful and exactly what I was looking for! I now have a massive head start in helping the people in my community.

The course surpassed all my expectations. It was all good and encompassing. I think your style which allows for conversation toward what the participants find useful or of interest works really well. And having the day-to-day forms, infusions notes, and protocol/SOP forms are just so exceedingly helpful.

About the "ketamine experience"... for me personally I would like to try it again to get the larger experience! Unfortunately for you, I only trust you to do it. To see the differences between the way people respond to the experience really brought it home.

It was Excellent!"

Edward Campbell, MD - Anesthesiologist


"I thoroughly enjoyed the course and thought it was a good mix of science and practical knowledge. And of course, it was very helpful as I had no clinical experience with Ketamine and just a little knowledge from what I’ve read...

It gave me a clear road map moving forward. I’m sure there is a lot still to learn, but you never know what you don’t know until it arises....Having access to your forms and waivers, etc. is huge!...

No other training offers an actual infusion for us to experience what it’s like. Having done it now, I can appreciate how difficult it would be to explain it without having done it."

David Smith, MD - Internist/Family Practice


Relevant Current Research Articles


Additional recently published research articles may be found in our RESEARCH section


The Ketamine Research Institute

The Ketamine Institute is leading the way in the field of ketamine infusion therapy and physician education with our new ketamine infusion training program. We’re on a mission to accelerate the health care revolution. We have pioneered ketamine infusion therapy to bring the latest breakthrough discoveries about ketamine out of the research lab and into our infusion centers.


Ketamine Institute Logo Verticle

A New Therapeutic Option for Depression and Pain

The Restore Ketamine Inusion