Ketamine Infusion Training Programs for Clinicians

Ketamine Infusion Training Programs

"Our program represents the first standardized ketamine infusion training course for physicians, promoting an effective, safe and uniform infusion protocol for the treatment of mood disorders"....

Ketamine Research Institute

Ketamine Infusion Therapy for Clinicians 

Thank you for your interest in our training program. However, due to increasing clinical demands resulting from the recent surge in mood disorders and COVID-19 post-infectious syndrome, as well as,  the continuing uncertainty, travel restrictions and vaccine requirements regarding COVID-19, we will not be holding small group sessions or intensive “one-on-one” individual training until sometime late in 2021.

The Ketamine Infusion Therapy for Clinicians basic workshop course outline and manual will become available online as an optional learning modality during the second quarter of 2021. However, it will not include live didactic instruction, demonstration, or personal clinical experience.

I would be happy to keep you informed when we resume our usual training program.

Gerald W. Grass, MD

Ketamine Infusion Therapy for Clinicians is the only coordinated and comprehensive training program in the use of ketamine therapy for physicians in North America. The program meets or exceeds the American Psychiatric Association consensus recommendation for ketamine therapy and the American Society of Anesthesiology guidelines for monitoring and airway management requirements, based on the Yale-National Institute of Mental Health protocol.

The Ketamine Infusion Therapy for Clinicians program is comprehensive in that its teaching content is not restricted to theory or academic interest but grounded in almost 20 years of active clinical ketamine infusion practice. All major aspects of ketamine therapy that have practical clinical value are represented in the program. The teaching approach stresses contemporary medicine and bioscience, yet addresses the full translational medicine and transpersonal aspects of ketamine therapy as derived from clinical and basic science research.

We are dedicated to ensuring that every student completing the course is competent in this new discipline and ready to incorporate it into practice. There is no other course in the country that invests as much attention and energy in each student. We are satisfied that we have created the gold standard in ketamine-based infusion therapy training.

Ketamine Research Institute Consulting Program

In addition to physician and practitioner training programs, the Ketamine Research Institute  Consulting Program provides newly certified practitioners an algorithm and a step-by-step guide to help practitioners developed the experience and expertise needed to get their ketamine infusion practice off the ground. We have helped psychiatrists, anesthesiologists, and other medical specialists get their private practice set up and paved the way for successfully helping hundreds of their patients. We have gone through it ourselves and have assisted others in the process.

Ketamine Research Institute Consulting and Mentoring team is made up of experienced ketamine professionals who are leaders in ketamine-based therapy. Our staff and practice partners will guide you through the process of becoming a certified ketamine infusion physician and establishing your ketamine infusion center in your current practice environment.  We will help you get started, connect you with resources, and be here for help with roadblocks along the way with onsite and in-office consulting.

We have been called upon for our expertise in the areas of physician and staff training, equipment and supplies acquisition, operations, and ongoing patient consultation and management by physicians around the world.  By working with us, clients have access to deeper levels of expertise on how to run, build and continue thriving providing ketamine-based infusion therapy in private practice setting.

Our Available Training Courses:

In the past, we offered two training options to suit individual practitioner needs, small group sessions and individual “one-on-one” intensive sessions. However due to increasing clinical time demands resulting from the surge in mood disorders and the continuing uncertainty regarding the COVID-19 infection, we will not be holding small group session again until sometime 2021. The intensive “one-on-one” training will still be available when clinical time becomes available throughout the year. 

Small Group Intensive Course 

The small group sessions, usually consisting of 2-3 practitioners, provides the comprehensive training necessary to fully understand the clinical concepts and application of ketamine-based therapy, as well as, safely and effectively administer infusion therapy to patients in an out-patient, private practice environment.

It is held over an intensive two-day period and covers all principles and practices necessary to begin ketamine infusion therapy. It also expands the learning experience by providing detailed information and examples of necessary clinical, office and regulatory documentation, monitoring and optimization protocols. The course in usually limited to 2-3 clinicians to facilitate a small group learning environment, discussion and familiarize them with an actual ketamine infusion center.

While with us, clinicians have an opportunity to become familiar with the actual environment in which infusions are performed and includes demonstration of the necessary monitoring equipment, intravenous delivery systems, and supplies necessary for the safe administration, storage and handling of ketamine.

"One-on-One" Private Intensive Course

The “one-on-one” intensive training is customized to each practitioner’s needs and skill level. It delves deeper into specialized aspects of ketamine pharmacokinetics and pharmacodynamics, including the effects of patient specific metabolism, medication interactions and genomic variables on ketamine metabolism and efficacy. It also includes pertinent intra-infusion monitoring modalities and methods to calculated infusion serum concentrations. Additional information is supplied regarding practical aspects of equipment and supply requirements, staffing requirements, drug acquisition and storage. This option provides expanded clinical information, insights and ketamine infusion experience for those who are interested in optimizing infusion benefits. Physicians who undertake the one-on-one training are also given the opportunity to experience a ketamine infusion first-hand to fully understand the unique psychological benefits and therapeutic potential.

We also review various options related to 2R,6R HNK pharmacokinetics, to optimized the treatment efficacy and duration of benefit of the standard ketamine infusion. Clinicians who complete the "one-on-one" Intensive Course are also provided with ongoing personal mentoring.

Course Content

Both of our courses meet and exceed consensus recommendations published by the American Psychiatric Association and the American Society of Anesthesiologists.  Practitioners who complete either course are provided with the comprehensive course manual which summarizes all of the lecture and presentation concepts and provides the necessary scientific references supporting ketamine therapy.  Also included are examples of required DEA documentation, treatment consents, medical evaluation and treatment records. In addition, participants are provided with certification of training by the Ketamine Research Institute, assistance during the initiation phase of their ketamine infusion practice and are invited to participate in our ongoing discussion board and chat group.


Ketamine Infusion Therapy for Mood Disorders

Intensive Course

Both courses not only cover all of the practical aspects ketamine therapy, but expands into scientific principles allowing optimization of the basic protocol.  All course training is conducted “on site” in an actual infusion center so that you will have an opportunity to become familiar with the environment in which infusions are performed. This includes demonstration of the necessary monitoring equipment, intravenous delivery systems, and supplies necessary for the safe administration, storage and handling of ketamine. The course specifically trains participants to safely and effectively administer the ketamine infusion protocol developed at Yale in 1994-2000 and currently used by the National Institute of Mental Health and other major institutions around the world.

How to effectively integrate ketamine therapy into your current practice

Download Course Brochure



Intensive Course Description

The course content is comprehensive and integrated. It systematically embraces all major aspects of ketamine therapy and emphasizes the incorporation of ketamine-based therapy into contemporary professional practice.

Course Content

Day 1

Module 1 - A New Way of Looking at The Treatment of Mood Disorders
                     Are Conventional Antidepressants Obsolete?
                     Ketamine - A New Path to Depression Relief
                     The Human Connectome Project and How It Impacts Depression
                     Ketamine as Molecular Neuromodulation Therapy

Module 2 - The Current Scientific Evidence Supporting Ketamine Therapy - Part I
                    Why You Should Perform Ketamine Infusions
                    What is Ketamine - The Strange History of CI-581
                    Repurposing an Old Drug - 50+ Years of Clinical Use
                    Overview of the Current Scientific Evidence for Ketamine Therapy
                    Comparison of Ketamine Therapy vs. Standard Treatment, ECT and rTMS

Module 3 - The Current Scientific Evidence Supporting Ketamine Therapy - Part II
                    Pharmacodynamic and Pharmacokinetic Aspects of Ketamine Therapy
                    Ketamine Interactions at the NMDA, AMPA, HCN1 and Other Receptors
                    Research into other Ketamine Like Compounds - Will They Be Effective?
                    Spravato - Is it an alternative to the Ketamine infusion?
                    Beyond the Pharmacological Effects of Ketamine - Transpersonal Aspects


Day 2                   

Module 4 - Practical Clinical Aspects of Ketamine Therapy
                    Patient Selection and Evaluation for Ketamine Therapy
                    Reviewing Medical Records, Pre-Procedure Labs and EKG
                    Contraindications to Ketamine Therapy - What are They?
                    Intravenous vs. Intramuscular or Other Routes of Administration
                    Is Ketamine Abuse and Substance Dependence an Issue?
                    Medicolegal Concerns About "Off-Label" Use of Ketamine

Module 5 - The Ketamine Infusion Protocol
                    Pre-Procedure Assessments and Documentation Requirements
                    Equipment Requirements Necessary for Providing Ketamine Safely
                    The Ketamine Infusion Protocol - Pitfalls and Pearls
                    Adverse Effects Associated with Ketamine Therapy - How to Manage Them
                    Post Procedure Observation and Interview                          

Module 6 - Optimizing Outcomes and Expanding Indications for Ketamine Therapy
                     How To Optimize The "Standard" Protocol  for Maximal Benefit
                    Treating Complicated Patients with Co-Morbid Conditions
                    The Expanding Indications for Ketamine Therapy
                    The Ketamine Institute Mentoring Program

Advantages of This Program

The Intensive Ketamine Infusion Therapy Training Course is offered by special arrangement several times per year. This insures that each practitioner will have the maximal opportunity to work directly with us to facilitate the learning experience and rapidly gain the skills and understanding necessary to perform ketamine infusion therapy.

The course content is comprehensive and integrated. It systematically embraces all major aspects of ketamine therapy. Each step in learning is anchored to pragmatic applications and realistic clinical situations seen in daily practices. The format of the program is convenient for the busy practitioner wanting to assimilate a new discipline with multimedia learning with lecture, reading, and video demonstration.

The comprehensive course workbook, included with the course, summarizes all of the lecture and presentation concepts and provides the necessary scientific references supporting ketamine therapy. In addition, it contains examples of the required DEA documentation requirements, consents, medical evaluation and treatment records. Additional information is supplied regarding practical aspects of equipment and supply requirements, staffing requirements, drug acquisition and storage.

For additional information, please contact us at:

Or download the program brochure and fax all required documents to:


What Our Graduates Are Saying

"I am an Austrian psychiatrist. One year ago, I started using ketamine for the treatment of my depressive patients without formal training using the standard protocol published in the literature.  I decided to attend the Ketamine Institute’s training program to enhance my skills.

The Ketamine infusion therapy for mood disorders” training course for physicians went above and beyond my expectations. Dr. Grass' brilliance and profound professional expertise made this course an unforgettable and truly eye-opening experience. I can now understand Ketamine from a pharmacological, anesthesiology, psychiatric, medico-legal and therapeutic perspective. I could put the contents I learned immediately into practice and my patients are already profiting from the knowledge I gained."

Since completing the course, Dr. Landauro writes…

"I arrived safely to Salzburg yesterday. Today we are performing our first optimized ketamine infusion. My patients and I are excited about this.

I treated the first wave of my ketamine eligible patients. Last Friday I talked to Ingrid. She couldn’t stop thanking me. To be sincere, I would have never thought any kind of improvement to be possible in her case. Ingrid’s depression is cracked - not in remission - but really cracked. 40 years of treatment from some of the greatest minds in the country couldn’t do the trick; the brilliant new protocol I learnt from you did. She had her first “not very painful 2 weeks” she can remember. She still complains, she still feels bad - but not so bad. I will come back to Ingrid later…

The sheer fact that I have the option to apply the optimized protocol gives my clients strength. It’s a whole new experience for them when I tell them “you don’t have to suffer longer than you want to.” I make them aware that we can “eradicate” 80% of depressions in a week. It gives them confidence and a reason to hope.

I went to Florida to learn how to give infusions properly, I came back with a huge arsenal of psychiatric-psychotherapeutic power-tools.

I wish you would have heard Ingrid saying…
…thank you!"

-Dr. Med R Febres Landauro – Saltsburg, Austria

Individual and Small Group Intensive Tutorials
are available by special arrange


Relevant Current Research Articles


Additional recently published research articles may be found in our RESEARCH section


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The Ketamine Institute

The Ketamine Institute is leading the way in the field of ketamine infusion therapy and physician education with our new ketamine infusion training program. We’re on a mission to accelerate the health care revolution. We have pioneered ketamine infusion therapy to bring the latest breakthrough discoveries about ketamine out of the research lab and into our infusion centers.


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A New Therapeutic Option for Depression and Pain

The Restore Ketamine Inusion