The Ketamine Research Institute "Mini-Fellowship" Intensive Training Program
The Premier Ketamine Therapy Training Course for Clinicians
The Premier Ketamine Therapy Training Course for CliniciansIf you’re an MD, DO, NP, or CRNA seeking to revolutionize your practice and establish yourself as an expert in ketamine therapy, look no further. The Ketamine Research Institute’s "Mini-Fellowship" Intensive Training Program is not just another ketamine course—it’s the definitive pathway to clinical excellence, patient satisfaction, and professional recognition in this rapidly evolving field.
Your Success with Ketamine Therapy Hinges on Choosing the Right Training Program
The increasing popularity of ketamine therapy has led to a proliferation of training programs. However, the quality of these offerings varies widely, leaving clinicians—particularly those new to ketamine—struggling to identify programs that provide the depth and rigor needed to ensure safe, effective treatment. Many programs lack a unified, evidence-based curriculum, relying instead on multiple instructors with inconsistent expertise. This fragmented approach can result in subpar outcomes for clinicians and patients alike.
Many Training Programs Rely on Old Ketamine Techniques: Here’s Why You’re Setting Your Patients Up for Failure"
Many existing ketamine training programs continue to teach outdated, standard infusion protocols, including the conventional 0.5 mg/kg dosing recommendations, which were never subjected to large-scale clinical testing. These protocols often rely on a one-size-fits-all approach, resulting in imprecise dosing that frequently leads to under or overdosing in real-world patients.
This can result in therapeutic plasma levels that are either too low to produce efficacy or too high, increasing the risk of adverse effects. As research studies continue to show, such approaches lead to poor and inconsistent treatment outcomes, with many patients experiencing minimal benefit or discontinuing treatment altogether.
Clinicians trained in these outdated protocols may unknowingly perpetuate these same suboptimal outcomes, leaving both themselves and their patients at a distinct disadvantage in a rapidly evolving field of precision medicine. By choosing programs that still adhere to these imprecise guidelines, clinicians risk not only compromising their practice but also providing substandard care that falls behind the latest advances in ketamine therapy.
Outdated Ketamine Protocols = Disappointing Results: Are You Setting Your Patients Up for Failure?
While high-quality research studies report impressive results for ketamine therapy, real-world outcomes often fall alarmingly short. Studies show that less than 50% of patients experience significant improvement in symptoms when treated in community-based settings, and up to 8% may experience worsening symptoms (McInnes et al., 2022; Sakurai et al., 2020; Wilkinson et al., 2018).
In addition, many patients fail to complete the induction series or discontinue treatment prematurely, with up to 47% dropping out due to adverse effects or insufficient improvement (Kumar, PS. et al., 2024). Worrisome, too, are reports that some patients may not only experience a worsening of their symptoms but report becoming suicidal after treatment (McInnes et al., 2022;), further emphasizing the need for rigorous, evidence-based training to minimize these risks.
These discrepancies are often due to inadequate clinician training, inconsistent protocols, and insufficient patient preparation or follow-up care. Such shortcomings not only undermine the potential of ketamine therapy but can also harm its reputation as a transformative treatment.
What Clinicians Should Demand in Training
Clinicians seeking to offer ketamine therapy must prioritize training programs that adhere to the American Psychiatric Association (APA) and American Society of Anesthesiologists (ASA) recommendations for comprehensive education. More than that, training programs should advance the knowledge base of ketamine therapy, including:
Didactic Education: Evidenced-based and experience-proven detailed instruction on ketamine’s complex pharmacology, mechanisms of action, drug-drug interactions, indications, and risks.
Advanced infusion protocols: based on individualized dosing and precision medicine to ensure optimal therapeutic outcomes.
Enhanced Patient Evaluation: prioritize enhanced patient evaluation and optimization, considering factors like genetics, comorbidities, and medication interactions to maximize safety and efficacy.
Supervised Clinical Training: Real-world experience administering ketamine under close supervision to build confidence and skill.
Individualized Mentorship: Although not explicitly required, the benefit of ongoing guidance from experienced professionals to refine clinical practices and address complex cases is invaluable.
Research also underscores the importance of hands-on training to equip clinicians with the skills to deliver consistent, high-quality outcomes (Sanacora et al., 2017). Without these elements, clinicians risk perpetuating the common pitfalls seen in many community practices, such as improper dosing, failure to manage adverse effects, suboptimal patient preparation, and subpar treatment outcomes.
The KRI "Mini-Fellowship" Program - Elevating Standards, Transforming Practice
To bridge the gap between research and real-world practice, clinicians must select training programs that combine:
Rigorous education on ketamine’s clinical applications.
Real-world practice with hands-on experience.
Long-term mentorship to ensure continual improvement and refinement.
By investing in a program that integrates these essential components, clinicians can confidently deliver transformative care while achieving the high success rates seen in research studies. Such training not only improves patient outcomes but also distinguishes the clinician’s practice as a leader in the field of ketamine therapy.
The Mini-Fellowship Program is the only training that corrects these widespread issues by integrating enhanced patient evaluation criteria, personalized medicine, and target-determined infusion methodologies.
Why Choose the Mini-Fellowship?
Set a New Standard of Care
Our immersive 3-day intensive combines small-group, personalized tutorials with practical application, ensuring you gain skills that lead directly to exceptional patient outcomes. With exclusive insights and techniques other programs overlook, the Mini-Fellowship empowers you to rise above the standard and achieve clinical success.
Cutting-Edge Knowledge: Evidence-based and experience-proven techniques for safer, more effective treatments.
Hands-On Training: Real-world skills to confidently elevate your practice.
Personal Experience: Firsthand exposure to ketamine therapy for a deeper patient connection.
Ongoing Mentorship: One year of expert guidance to refine and perfect your approach.
Whether you're just starting or seeking to enhance your current practice, this training equips you to deliver superior outcomes safely and confidently. Plus, with a full year of professional mentorship, you’ll have the ongoing support needed to master this groundbreaking treatment.
Transform your practice—enroll in the Mini-Fellowship today and become a leader in ketamine therapy.
The Precision Medicine Difference
Personalized medicine is the cornerstone of modern healthcare, and ketamine therapy is no exception. In our program, you will learn how to:
Leverage genetic insights: Understand how variations in CYP450 enzymes and NMDA receptor subtypes influence ketamine metabolism and response.
Optimize dosing: Learn to adjust infusion rates and dosing strategies based on patient-specific factors such as mass, concurrent medications, and comorbidities.
Predict and prevent side effects: Use pharmacogenomics and clinical biomarkers to minimize adverse events and ensure a smoother treatment experience.
These advanced techniques empower you to deliver treatments that are not only effective but also well-tolerated, setting you apart as a practitioner who truly understands the science behind ketamine therapy.
What Is Target-Determined Infusion Methodology?
Unlike conventional dosing protocols, which rely on fixed-dose regimens - the "one-size-fits-all" approach, our target-determined infusion methodology focuses on achieving precise therapeutic plasma concentrations of ketamine. This approach:
Focuses on the therapeutic window and achieving optimal plasma concentrations: Avoids underdosing (which leads to inadequate results) and overdosing (which increases side effects).
Uses real-time adjustments: Incorporates patient feedback and clinical observations during infusions to optimize treatment in real-time.
Individualizes every session: Recognizes that no two patients are alike and ensures that every infusion is tailored to their unique needs.
This advanced methodology is exclusive to the Mini-Fellowship and is not taught in other ketamine training programs. By mastering this technique, you will achieve consistently superior outcomes and set a new standard for patient care.
A Program Designed for Excellence
The KRI "Mini-Fellowship" Intensive Training Course is the premier program for clinicians seeking to master ketamine infusion therapy. Unlike other training options, our course doesn’t just meet the rigorous standards set by the American Psychiatric Association and the American Society of Anesthesiologists—it redefines them, offering unparalleled depth and expertise.
What distinguishes the Mini-Fellowship is our relentless focus on equipping you with advanced, practical knowledge of ketamine pharmacokinetics. This empowers you to deliver safer, more effective, and better-tolerated treatments—setting your practice apart and transforming patient outcomes.
Our program offers an unmatched combination of supervised, hands-on clinical experience and a unique opportunity to undergo a ketamine infusion yourself. By experiencing firsthand what your patients will, you'll gain invaluable insights that elevate your clinical decision-making and patient care.
We don’t stop at training—we invest in your long-term success. Graduates receive an entire year of personalized mentoring and professional consultation, ensuring you're supported as you navigate the complexities of ketamine therapy in real-world practice. With KRI, you’re not just learning—you’re building a foundation for excellence and leadership in this transformative field.
Become a "Ketamine Expert" and not just another "Ketamine Clinic."
What Our Graduates Have to Say:
"Dr Grass,
I greatly enjoyed the training and found it to be detailed and oriented in a way that I could truly learn from. I raved to many of my colleagues regarding the training, including several who have Ketamine clinics. Just from the three-day course, the Ketamine providers could already tell the training I had received was leaps and bounds ahead of how they provide care.
The training exceeded my expectations. The personal Ketamine experience was a great addition to the training, and I truly believe it will aid my ability to treat my patients and share my experience with them.
Thank you again for the wonderful training."
- Shaun Madahar, MD
A Comprehensive Program to Mastering Ketamine Therapy
An Overview of Our Program:
Our 3-day intensive course is designed to provide clinicians with unparalleled knowledge, practical skills, and personal experience in ketamine therapy. Whether you're just beginning to integrate ketamine into your practice or seeking to deepen your expertise, this course offers an unmatched opportunity to become a leader in the field.
Day 1: Essential Foundations for Ketamine Therapy
Day 1 sets the stage by equipping you with a solid foundation in both the science and regulatory aspects of ketamine therapy. Starting with Dr. Zarate's groundbreaking research, we explore why ketamine is a game-changer for mood disorders. You'll delve into the dual mechanisms that bridge brain chemistry with psychological well-being, understand ketamine's history, and tackle the tough questions about its therapeutic use.
This day also emphasizes the importance of navigating complex regulations and ensuring compliance with governing bodies like the APA, ASA, DEA, and state medical boards. By the end of Day 1, you'll have the confidence to integrate ketamine into your practice safely and effectively.
Day 2: Advancing The Science of Ketamine Therapy
On Day 2, we confront the realities of current ketamine practices, exploring why "real-world" ketamine therapy often falls short. Through key studies from Yale, Harvard, and Osmind, you'll uncover the systemic issues and learn how to navigate the unregulated frontier of ketamine therapy. This day isn't just about identifying problems but finding solutions.
You'll gain critical insights into the science of ketamine infusion, master pharmacokinetics, precision dosing, and understanding the physiological and phenomenological responses patients may experience. By addressing the five key factors—mass, medications, medical comorbidities, metabolism, and mindset—this day ensures you're prepared to deliver the highest standard of care.
Day 3: The Next Step: Precision Medicine and Target-Determined Infusions
Day 3 focuses on the critical variables that determine ketamine efficacy and the power of personalized medicine. You'll learn how to fine-tune your approach to each patient, ensuring that therapy is tailored to their specific needs. This day covers advanced patient selection, the role of diagnostics and genetics, and the importance of biomarkers.
You'll also explore the application of precision dosing and targeted infusions across various disorders, including anxiety, PTSD, depression, fibromyalgia, and chronic pain. With a focus on real-world application and the development of advanced treatment protocols, Day 3 ensures you're fully equipped to provide the most effective and personalized ketamine therapy.
Clinical and Experiential Sessions: Gain Unmatched Expertise in Ketamine Therapy
To truly learn ketamine therapy, you need "hands-on" experience
To truly learn ketamine therapy, you need "hands-on" experienceWhat truly sets this course apart is the combination of rigorous clinical practice with deep personal experience. Days 2 and 3 of our ketamine training course are dedicated to transforming theoretical knowledge into practical expertise.
These sessions offer clinicians an unparalleled opportunity to engage in supervised clinical training and experience ketamine's effects firsthand. This combination of hands-on practice and personal immersion ensures that our participants develop the competence and confidence needed to excel in ketamine therapy.
Supervised Clinical Training: Mastering the Art of Ketamine Infusions
Elevate Your Skills with Real-World Ketamine Infusion Practice
Elevate Your Skills with Real-World Ketamine Infusion PracticeIn addition to our advanced didactic sessions, clinicians will receive advanced training under expert supervision, mastering every aspect of the ketamine infusion process—from meticulous pre-procedure preparation to precise infusion techniques and thorough post-procedure care.
You'll learn to create the optimal infusion environment, fine-tune dosing, and manage psychological and physiological responses during treatment. This real-world application of advanced pharmacokinetic modeling and electronic infusion records sets this course apart, providing you with the skills to deliver safe, effective, and patient-focused care.
Stepping into Your Patients' Shoes: Experience Ketamine Firsthand and Transform Your Practice
Go Beyond Theory: Experience Ketamine’s Profound Effects and Elevate Your Clinical Skills
Go Beyond Theory: Experience Ketamine’s Profound Effects and Elevate Your Clinical SkillsWhat truly differentiates this course from all others is the opportunity for clinicians to experience ketamine's profound effects themselves. By personally navigating the non-ordinary states of consciousness induced by ketamine, you'll gain invaluable insights into the patient experience.
This firsthand understanding enables you to prepare better and support your patients, reducing their anxiety and increasing the efficacy of the treatment. No other training program offers this level of immersive learning, making it a critical component for clinicians who aim to provide the highest standard of care.
Why Choose This Course?
In an era where mental health treatment demands innovation and precision, mastering ketamine therapy through our advanced training represents a transformative step forward for clinicians. By choosing our program, you are investing in the advanced skills, knowledge, and professional development necessary to excel in ketamine therapy, setting yourself apart in a crowded marketplace and ensuring the highest quality care for your patients.
Our comprehensive curriculum equips you with the tools, insights, and confidence to succeed, and our graduates emerge fully prepared to deliver exceptional care, leading the way in the future of ketamine therapy.
To learn more about the KRI Mini-Fellowship Program, you can visit our more extensive training program website - The Ketamine Reseacrh Institute Training Program
Hear from Our Alumni:
"Dr. Grass:
This is just a token of appreciation for your time and patience. When I enrolled in your program, it was not my intent to participate by exhaustively asking questions, but it became apparent that I had overestimated my fund of knowledge.
Although I have extensive clinical experience with ketamine, and I work at expanding my understanding of the fundamental physiology and pharmacology involved in the administration of ketamine for mental health disorders, I had no idea how much I didn't know.
All the knowledge that I had acquired needed the perspective and clinical understanding that you were willing to share. Thanks again for your help.
Your program exceeded all expectations."
— Mark Garwin, MD - Anesthesiologist
Apply Now
Limited Enrollment:
Class Schedule for 2025:
June 26th through 28th - Class Full - Waiting List Available
The next training session is scheduled for September 26th- 28th
Our specialized ketamine training program maintains rigorous educational standards by accepting only three to five clinicians per course, ensuring an intimate and transformative learning experience.
This exclusive approach guarantees each participant receives in-depth didactic instruction, comprehensive supervised infusion training, and the opportunity for a personal ketamine experience under expert guidance.
By limiting enrollment, we provide individualized attention, deep clinical immersion, and a supportive environment that allows clinicians to develop professional competence and personal insight into the therapeutic potential of ketamine-assisted treatments.
Applications are evaluated and accepted on a "rolling basis." Courses typically fill several months before the start date, so please apply early to secure your position.
We're not just teaching clinicians—we're cultivating the next generation of ketamine and psychedelic medicine innovators. With limited seats across multiple sessions, this is your opportunity to redefine your clinical practice and pioneer breakthrough therapeutic approaches.
Private group sessions are available for the entire office; clinicians, nurses, and office staff are available upon special arrangement.
Download the Training Course Application
Our Goal
Our goal is to train the Top 100 Ketamine Clinicians in the United States. Our graduates will become leaders in their field, highly respected ketamine experts, and serve as professional examples of clinicians providing the safest and most effective ketamine therapy available.
The "Mini-Fellowship" training program has been developed to ensure that high standards and effective treatment in ketamine therapy are maintained. Our intensive training program provides practitioners with the most up-to-date evidence-based education and training in ketamine therapy, supervised clinical experience administering ketamine therapy, and personalized mentorship available to ensure that the highest standards are met.
Our Experience and Qualifications
Gerald W. Grass, MD - Course Director
The "Mini-Fellowship" Intensive Training Program for Clinicians is a sophisticated and advanced training program that results from over 35 years of clinical research and experience in ketamine practice. Over the past three decades, I have conducted clinical ketamine research and provided thousands of hours of continuously monitored ketamine infusions to individuals worldwide, gaining invaluable experience in various clinical circumstances. Our work has been presented at national conferences and academic and governmental institutions providing educational programs in the use and future application of ketamine therapy.
In addition, I have served as principal investigator for pharmaceutical companies engaged in Phase III drug trials for psychopharmacological agents seeking FDA approval and as clinical advisor to various organizations and biotechnology firms.
All of this experience is then distilled down and passed on to our attendees through didactic lectures, small-group discussions, and hands-on opportunities to administer ketamine under direct supervision. We offer this wealth of experience and knowledge to participants in our program so they can return to their practices confident in their abilities to provide ketamine-based therapy safely and effectively. The bottom line is that we can provide you with the knowledge, experience, and skills necessary to be a well-respected and successful clinician providing ketamine therapy in your community.
After the Course
After the program, clinicians will be certified by the Ketamine Research Institute as qualified ketamine therapy providers with supervised clinical experience. This certification is the first step in becoming a highly skilled and successful ketamine practitioner. We invite you to join our growing network of practitioners transforming patient care through evidence-based best practices.
Our program is exceptional and exceeds all didactic and clinical recommendations published by the American Psychiatric Association and the American Society of Anesthesiologists. It also includes the added benefit of an experiential component to understand and appreciate the uniqueness of ketamine infusion therapy fully. We are committed to helping clinicians learn how to provide these treatments safely and effectively.
Please consider joining us - we look forward to working with you!
How to Apply for Training
Download the course application here
Here's What Our Graduates Are Saying
"I thoroughly enjoyed the course and thought it was a good mix of science and practical knowledge. And of course, it was very helpful as I had no clinical experience with Ketamine and just a little knowledge from what I’ve read...
It gave me a clear road map moving forward. I’m sure there is a lot still to learn, but you never know what you don’t know until it arises. Having access to your forms, waivers, etc., is huge!
No other training offers an actual infusion for us to experience what it’s like. Having done it now, I can appreciate how difficult it would be to explain it without having done it."
— David Smith, MD - Internist/Family Practice
"Thank you so far for your help! Seems no matter how much you read and study, every patient can be different so definitely an art to this and grateful to have you as an experienced practitioner in all this.
I have also had meetings with two physicians - psychiatrist and pcp and discussed my dosing and what I’ve learned from you, and really seems that your protocol definitely provides a better sense of science and overall safety for our patients.
It’ll be great to have more providers in my local area who are on board with sending me their patients and can trust what I’m doing here. Thanks again, and I’m sure we will be in touch again soon."
— Erin Boyd, DO - Lumina Mind Health
"Dr. Grass:
This is just a token of appreciation for your time and patience. When I enrolled in your program, it was not my intent to participate by exhaustively asking questions, but it became apparent that I had overestimated my fund of knowledge.
Although I have extensive clinical experience with ketamine, and I work at expanding my understanding of the fundamental physiology and pharmacology involved in the administration of ketamine for mental health disorders, I had no idea how much I didn't know.
All the knowledge that I had acquired needed the perspective and clinical understanding that you were willing to share. Thanks again for your help.
Your program exceeded all expectations."
— Mark Garwin, MD - Anesthesiologist
Please click here to learn more about what our graduates say
To Learn More About Our Programs - please click the links below:
The "Mini-Fellowship" Intensive Training Program
A Detailed Course Overview - Elevate Your Expertise in Ketamine Therapy
Day 1: Essential Foundations for Ketamine Therapy
Day 2: Mastering the Future of Ketamine Therapy
Day 3: Taking it to The Next Level: Personalization and Precision in Ketamine Therapy
Our Course Schedule and How To Apply For Training
The Origin of Our Ketamine Training Program
What Our Graduates Say About The Course
How the Ketamine Research Institute Training Program Complies with APA and ASA Recommendations
Our Mission
The Ketamine Research Institute's mission is to train the next generation of healthcare providers in evidence-based best practices for administering safe and effective ketamine-based treatments. We are dedicated to providing clinicians with comprehensive training that is accurate, up-to-date, and clinically relevant.
