Learn About the RESTORE Essential Infusion


The RESTORE Essential Infusion is a more sophisticated and innovative formulation of ketamine infusion.  It incorporates innovative genetic, metabolic, and medication assessments and optimized infusion protocols to increase efficacy in complex and challenging conditions that have been resistant to other conventional treatment approaches.

Not everyone reacts to medications in the same way. Many people experience frustration when they don't receive relief after trying multiple antidepressants or other treatments such as rTMS, ECT, Spravato, psilocybin or standard ketamine infusions.

The RESTORE Essential Program provides many of our patients with relief of their symptoms for 1-3 years or more - unlike ketamine infusions which typically only last 4-6 weeks. Recommended for patients with severe Depression, Bipolar Disorder, Burnout Syndrome, or Complex PTSD who have not respond to:-

2 or more antidepressant medications
Transcranial Magnetic Stimulation (rTMS)
Electroshock Therapy (ECT)
Spravato (Esketamine)

And those who are prescribed:

Stimulants: Vyvanse, Adderall, Ritalin, Dexedrine, Concerta, Strattera or
Mood Stabilizers: Lamictal, Risperdal, or Zyprexa

Please note, patients known to have complex genetic or metabolic issues and those who have failed to improve following prior ketamine infusion therapy or psychedelic therapies including psilocybin or MDMA may require the RESTORE Advanced Infusion Program.

Successful infusion therapy must be custom-tailored to the individual and the specific medical condition to achieve the best effect in these challenging conditions. The RESTORE Essential Infusion program provides a detailed, personal evaluation that may include obtaining a sophisticated genetic and metabolic profile with specific recommendations and assistance with optimization before beginning infusion therapy to achieve long-lasting relief.

In addition to each patient's metabolic and genetic optimization, each RESTORE Essential infusion is administered using a proprietary infusion protocol with continual adjustment.  The protocol provides the optimal concentration of medication necessary for complex conditions over a more extended period of time.

That is why RESTORE Essential can achieve rapid symptom relief for those who have not improved with multiple antidepressants, rTMS/ECT treatments, or prior ketamine infusions.

RESTORE Essential can accomplish in just 3 sessions what others may not be able to achieve with 6-9 or more ketamine infusions.  Not only that, the benefits of feeling better last much longer than those seen with the regular, basic ketamine infusion.

Currently Used To Treat:

Mood Disorders:                         Has Been Helpful in:                         
Depression                                    Fibromyalgia
Bipolar Illness                               Migraine Headaches

RESTORE Essential Infusion Series Includes -

Initial Evaluation:
Comprehensive Initial screening and assessment:
Review of medical records, depression, anxiety, and pain metrics.
Review of all previous laboratory tests and evaluations.

Also includes -
Review and optimize critical metabolic issues, including thyroid hormone levels, testosterone/estrogen levels, Vitamin D, B6, and B12 levels as necessary. Additional testing for acetyl-L-carnitine or ALCAR, hsCRP, and Magnesium levels.
In challenging presentations, Genomind genetic profile analysis may also require Cytochrome P450 function; serotonin, dopamine, and norepinephrine receptor variants, and MTHFR/BDNF variant screen.
Comprehensive treatment plan including extensive consultation with each patient and family members regarding infusion protocol and infusion experience.

Infusion Series:
RESTORE Essential three-part sequential optimized infusion

Each infusion is optimized to each patient's individual physiological and psychological response based upon pharmacokinetic parameters.

Also includes - 
Pre-Infusion analysis:
Genomic Profile: Infusion optimization per current medications, sex, adjusted body composition, and prior treatment history.
Pharmacokinetic Optimization: Each infusion is optimized based on computer modeling of blood level concentrations.
Pharmacodynamic Monitoring: Each infusion is monitored and adjusted based upon psychological and physiological responses.

A physician is always present with each patient:
Continual real-time monitoring, including
Heart rate and heart rate variability
Blood pressure
Pulse Oximetry

Also includes -
Autonomic nervous system monitoring and assessment
Pharmacokinetic monitoring
Reassessment of pharmacokinetic profile and response
Ongoing infusion adjustments and modifications.
Acoustic and visual modification and entrainment
RESTORE proprietary booster supplement.

Meets and exceeds recommendations:
American Psychiatric Association-
A Consensus Statement on the Use of Ketamine in the Treatment of Mood Disorders
American Society of Anesthesiologists-
Practice Guidelines for Sedation and Analgesia by Non-Anesthesiologists

Post infusion assessment by attending physician

Also includes - 
Review of physiological and psychological response
Review of pharmacokinetic and Pharmacodynamic response
Inter-Infusion re-evaluations and reassessments by the physician.

Maintenance Therapy:

The fewer maintenance infusions are needed –
After the first 3 infusions, patients generally require only two infusions at the three-month mark and one infusion at the six-month mark to become long-lasting (1-3 years in many cases). Of course, if something happens, such as a very stressful life circumstance or traumatic event, then subsequent infusion may be needed for a short time.


Long Term Relief - Following the three initial infusions, only two maintenance sessions are needed to obtain more extended-term relief.  Session 1 - Two infusions are performed at the three-month mark following the initial series, and then Session 2 - One infusion is performed at the six-month mark.  This advanced program provides many of our patients with relief lasting 1-3 years or more.

Very Effective – 85% of patients with complex or challenging conditions can experience improvement in their symptoms - even in those who have not responded to prior ketamine treatments, ECT, or transcranial magnetic stimulation (rTMS).
Very Rapid – Only requires 3 infusions, given over 3 days to complete
Very Long Lasting – Improvements last much longer than any ketamine infusion. Very few maintenance infusions are needed.
Cost-Effective – Initial Series and maintenance infusions cost much less (40%) over the first year of treatment than multiple ketamine infusions.
Time Effective –Less time away from home and work
Reduced Medication – Most patients find they can reduce or discontinue prior medications that were not helpful.


At present it is only available at the Ketamine Institute in Sarasota, FL, but we do plan to make it available at multiple locations in the future.


The total cost of the RESTORE Essential Infusion program for mood disorders is $3450.00
Once the initial therapy is completed and each person's optimal response level is determined, the cost of the maintenance infusions is $650.00.

*Now that you know the advantages of RESTORE, if you still feel that regular ketamine
infusion therapy is an option for you, then please
read our guide on
How to Choose The Best Ketamine Infusion Center - 2021.


Now that you know a little more about the RESTORE Essential Infusion, explore our other options

That is the RESTORE Essential Infusion difference.

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