Physician-led ketamine infusion therapy
A structured course of care, designed for you
How the RESTORE approach differs
Precision Medicine and Personalized Care
Just as we all know that no two people are exactly alike, we also know that they will not each respond to medication in the same way. Because of this, it is vital to select the right treatment for the right person to be maximally effective.
What is Precision Medicine?
According to the National Institute of Health and the Precision Medicine Initiative, precision medicine is "an emerging approach for disease treatment and prevention that takes into account individual variability in genes, environment, and lifestyle for each person." This approach will allow doctors and researchers to predict more accurately which treatment and prevention strategies for a particular disease will work in which groups of people. It is in contrast to a "one-size-fits-all" approach. Disease treatment and prevention strategies were developed for the "average" person, with less consideration for the differences between individuals.
Although the term "precision medicine" is relatively new, the concept has been a part of healthcare for many years. For example, a person who needs a blood transfusion is not given blood from a randomly selected donor; instead, the donor's blood type is matched to the recipient to reduce the risk of complications. Although examples can be found in several areas of medicine, the role of precision medicine in day-to-day healthcare is relatively limited.
We have embraced this approach and applied it to the science of ketamine-based therapy to optimize all of our RESTORE treatment protocols and enhance our patients' outcomes. In this way, we strive to provide the most innovative and effective treatment available.
As a former Assistant Professor at the Yale School of Medicine Department of Anesthesiology, where the ketamine infusion for depression was first developed, I have used ketamine-based therapy for many years, treating severe chronic pain conditions including PTSD and depression. I saw first-hand how the results could vary widely. I saw how important it was to "tailor" the treatment for each specific patient early on.
Over the years, it became clear that the "one-size-fits-all" approach didn't work well. I spent over ten years researching the various factors contributing to a patient's success or account for their failure to improve with ketamine.
Did You Know
How well RESTORE Infusion therapy works is measured for each patient on a validated rating scale. Some people do not respond at all, and we cannot tell in advance who they will be. The reason some do not respond is complex and can include genetic variations in liver metabolic pathways, receptor site (NMDA, AMPA, HCN1) variations were ketamine works, and in others a variant of the brain protein called BDNF (val66met or met66met), which does not promote new neuron growth and reconnection as quickly, if at all. There has also been increasing research that suggests that low levels of acetyl-L-carnitine are associated with a lack of response to treatment.
In addition, the medications you are taking may profoundly affect your ability to benefit from ketamine infusions. This includes some commonly prescribed drugs such as:
- Stimulants: Vyvanse, Adderall, Ritalin, Concerta, and Strattera.
- Chantix - varenicline
- Lamictal - Lamotrigine
That is why we carefully review all of your prior treatments, medications, and laboratory results before we consider a RESTORE Infusion. We will request that you arrange to have medical records and laboratories forwarded to us for review. After reviewing the medical records, we may either arrange to schedule an appointment for infusions or request additional laboratory evaluations as may be necessary. Some of the extra lab work that is often very helpful includes:
CBC with differential
Comprehensive metabolic profile
C-Reactive Protein
Female - Estradiol Level – FSH/LH Level
Male - Testosterone Free, Direct, Total LC/MS
Thyroid Profile II, Comprehensive
Vit D, B12, and folates
homocysteine and methylmalonic acid (MMA)
RBC Magnesium
MTHFR variant - very important
Acetyl-L-Carnitine – very important
Genomind gene assay – if possible
We strive to provide the optimal therapy for our patients, and we are sometimes surprised to find that others may have overlooked critical tests or other clinical information that has had a dramatic impact.
We "Target" Your Infusion...Precisely
As you can see, we understand that it is vitally important to consider individual differences in each patient and specifically tailor treatment to that person's unique circumstances. It is even more critical when considering ketamine-based therapy.
Until now, the standard ketamine infusion has been designed for the "average patient." We take the time to tailor the therapy to each patient, taking account of the factors described below. As a result of this "one-size-fits-all" approach, treatment results can vary widely - they can be very successful for some patients but not for others.
We know that it is critical to consider individual differences in people's genetics, metabolism, medications, life experiences, environments, and lifestyles. This information gives us the resources we need to target the RESTORE Infusions to each person's needs and the specific illnesses. Success requires time, expertise, experience, and attention to every detail… that's Precision Medicine.
Here Are Just A Few Examples
How Body Weight Measurements Effect Ketamine:
How Medications Effect Ketamine
How Genetic Heritage Effects Ketamine
People Are Different and Not All Ketamine Infusions Are The Same
The RESTORE Infusions are unique and were developed from 1998-2004 from earlier clinical research work utilizing ketamine to treat complex and severe neuropathic pain.
Realizing the difficulty with multiple infusions given over two weeks and the time-consuming need to return each month for "booster" infusions, RESTORE was developed around a measured target concentration and a three-day course rather than the standard ketamine infusion.
How Effective Is It?
The RESTORE Infusion Program is measured for each patient on a validated rating scale, before treatment and at intervals afterward. As a group, they have all suffered from severe and ongoing depression, anxiety, or PTSD and have been unable to obtain relief with standard therapies. This includes all current antidepressants and psychotherapy and even magnetic stimulation (rTMS) and electroshock therapy (ECT). More than that, we have helped people from all over the country who have even tried Esketamine (Spravato), Psilocybin (Magic Mushrooms), and multiple regular ketamine infusions that were unsuccessful. When it is done carefully, Precision Medicine combined with the RESTORE Advanced Infusion Protocol and Synergistic supplementation can make all of the difference between success and failure..
They had all been classified as treatment-resistant. Many had been told that "you just have to learn to live with it" and "there's nothing more we can do."
The Benefits of Precision Medicine – Targeted therapy means better results.
Some of these people respond and some do not. Using a proprietary treatment paradigm and protocol combining Precision Medicine (including each patients' medical history, genetic and metabolic profiles, and unique individual characteristics) with Personalized Care (minute-to-minute physician observation and optimization of blood levels during each infusion), as well as the unique RESTORE supplement® are how the infusion is planned and delivered.
Rapid Relief - Long-Term Improvement
The initial treatment series is just three 30-minute infusions, one every day for 3 days. Patients then begin to experience rapid relief, and the improvements last much longer. After that, RESTORE patients can do so well that they only need one enhancement infusion at the 3-month mark to achieve long-lasting results. Following this, no other maintenance infusions may be required. Depending upon individual life circumstances and conditions, some patients may request or need occasional maintenance infusions on an "as-needed" basis.
So, if time is a factor or your condition is complex, severe, or of extended duration, then the RESTORE Infusion may be a better option.
Conditions the program is used for
Mood Disorders - Migraines - Fibromyalgia - Pelvic Pain - Neuropathy
The RESTORE Infusion Program is dosed to a target concentration in the blood rather than to your body weight.
The program is used for not only mood disorders but also migraines, fibromyalgia, and painful neuropathy - including CRPS/RSD, while the standard infusion cannot. Many have also found substantial relief from pelvic pain and associated vulvodynia and pudendal neuralgia with RESTORE. Through our clinical research, we are beginning to find that it may also be helpful in Alzheimer's and neurodegenerative disorders such as Parkinson's Disease and MS pain syndromes.
Now you have choices....
Call Today!...800.850.6979
