Our programs

RESTORE Advanced

The course for chronic neuropathic and nociplastic pain. Three infusions over three days, a more concentrated preparation than the mood protocol, dosed to a measured target concentration in the blood.

Ketamine is FDA-approved as an anesthetic. It is not FDA-approved for chronic pain, and its use for that is off-label. Individual results vary and cannot be predicted in advance.

Chronic pain Are You a Candidate?

Who it is for

Pain that has not responded to the usual management

Fibromyalgia, peripheral neuropathy, and complex regional pain syndrome and RSD. What matters more than the label is the mechanism: ketamine acts centrally, so it is worth asking about in neuropathic and nociplastic pain, and much less so in pain driven by ongoing tissue damage.

We characterize and classify your pain before recommending a course. If it is primarily nociceptive, or if you have a new or worsening pain on top of a long-standing one, we will tell you this may not be the right treatment and explain why. The chronic pain page sets out that classification and what the published trials found for each condition.

A clinician showing the way into a quiet infusion suite.

One patient at a time, in a suite kept quiet for that reason.

We do not treat post-viral syndromes including long COVID, chronic fatigue syndrome, or irritable bowel syndrome. We are asked about all three. The evidence is preliminary and we do not offer treatment for them.

The course

What the program is

01Three infusions, three daysCompleted in a single visit. Day one informs day two, and day two informs day three.
02A different preparationMore concentrated than the mood protocol, because the pain literature and the mood literature point at different dosing.
03A physician in the roomOne patient at a time, with the physician present for the whole infusion and the early recovery.

Each infusion is adjusted to how you responded to the one before it. The RESTORE Method sets out how the dosing is calculated and why.

What is included

Everything in the course

Before treatment

  • Review of your medical records, prior laboratory studies and previous pain management
  • Baseline scoring on validated pain, depression and anxiety scales
  • Review of thyroid, testosterone or estrogen, vitamin D, B6 and B12, with further testing where indicated
  • A full medicine review, and a conversation with your prescriber where something may interfere

The infusions

  • Three sequential infusions, each adjusted to your own measurements and your response to the last
  • Dosing set from your adjusted body composition, current medications and prior treatment history
A nurse and a physician adjusting an infusion pump beside a seated patient.

The rate is adjusted during the infusion, not set once and left.

Monitoring throughout

  • A physician present with you for the whole infusion
  • Heart rate and heart rate variability, ECG, blood pressure and oxygen saturation, measured continuously
  • Infusion adjusted in response to what the monitors and you are showing

Afterwards

  • Post-infusion assessment by the physician who treated you, and reassessment between infusions
  • The same pain scales repeated, so the result is measured rather than remembered
  • Results sent to your physician or pain specialist if you would like
  • The RESTORE supplement after the course, included in the fee

What to expect afterwards

Relief from a single course is often temporary

This matters more in pain than it does in mood, and we would rather you read it here. In the controlled trials, where an effect was shown at all, it was usually measured in weeks rather than months, and repeat courses are common.1

After the first three infusions the usual pattern is two infusions at around three months and one at around six months. Whether you need them, and when, is decided by your score on a validated rating scale rather than by the calendar.

What the window is for matters as much as how long it lasts.

Several weeks of lower pain is an opening: pain low enough that physical therapy becomes tolerable and a limb can be moved and loaded. We ask that you have a therapist or referring physician lined up before you come, so the weeks afterwards are used rather than waited out.

Cost

What it costs

$4,950The full courseEvaluation, three infusions, monitoring, reassessment and the supplement. The $150 consultation is credited against this fee.
$875Each maintenance infusionCharged only once the initial course is complete and your own response level is known.

We are not in network with insurance. The fees page sets out what is and is not included, and gives the expected first-year cost.

Straight talk

What this program is not

It is not a cure. For most of the pain conditions above the published evidence is weak — too few studies, too small, or too mixed to settle the question — and the chronic pain page sets out the grade the guideline gave each one.

It is not a replacement for the physician managing your pain, and it does not replace physical therapy. It is not available anywhere but Sarasota at present, which means travel for most people.

It does not help everyone, and we cannot tell in advance who it will not help. If it is not working for you, we will say so early rather than sell you a further course.

References

1. Cohen SP, Bhatia A, Buvanendran A, et al. Consensus guidelines on the use of intravenous ketamine infusions for chronic pain. Reg Anesth Pain Med. 2018;43(5):521–546. PMID 29870458.

The other programs

RESTORE Essential RESTORE Rescue Compare the options

Related pages

CRPS and RSD Fibromyalgia Safety, Risks and Limits Fees

Talk to us

Is this the right program for you?

800-850-6979

Tell us your diagnosis and what you have already tried, and we will tell you honestly whether this course is likely to help.

RESTORE — ketamine therapy, done precisely.